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Showing 1 to 20 of 25 for “"cardiac regeneration"”.
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Mechanisms to enhance cardiac regeneration
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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NEW ADVANCED THERAPIES FOR DRUG DELIVERY IN CARDIAC REGENERATION.
L'abstract è presente nell'allegato / the abstract is in the attachment
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Architectural control of ice-templated collagen scaffolds for cardiac regeneration
… to produce biomimetic scaffolds to facilitate cardiac tissue regeneration. Ice-templated collagen scaffolds have demonstrated translational success in other clinical applications. The ice templating technique utilizes phase separation dynamics during solidification and subsequent sublimation of …
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The Epicardium as the Conductor of Cardiovascular Cells in Cardiac Regeneration
Stem cell therapy for cardiac repair is a field of regenerative cardiovascular medicine that is emerging as a promising therapeutic alternative to heart transplantation in patients suffering from chronic heart failure. Although promising, challenges to cell therapy for cardiac repair remain, …
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KDM4D Overexpression Enhances Cardiac Regeneration and Mitigates Myocardial Damage in Response to Ischemic Injury
Protection of myocardium as a means to retain cardiac muscle after injury and prevent the development of heart failure has eluded the field for decades. We recently reported that lysine demethylase KDM4D could partially prevent and reverse cell cycle gene silencing, resulting in modest adult …
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Development and assessment of supercharged platelets as a novel drug delivery mechanism for promoting cardiac regeneration
… causes, aiming to repair or replace damaged cardiac tissue to restore heart functionality. Platelets, small, anucleate and granular cells in the blood, are primarily known for their role in blood clot formation at sites of vessel damage. However, they are also a highly promising vehicle for …
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Development of the Clinical Application of miRNA with Proregenerative Effect on the Heart
… the heart and the lack of drugs able to foster cardiac regeneration. Our recent work has identified a few human microRNAs (miRNAs), in particular hsa-miR-199a-3p, able to stimulate proliferation of cardiomyocytes and, once expressed in the mouse heart using viral vectors, to induce cardiac …
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… burden. The advancement of treatments to improve cardiac repair post-MI requires the discovery of new targeted treatment strategies. Epicardial-to-mesenchymal transition (EMT) occurs post-MI as a mechanism to support neovascularization and cardiac healing. However, the endogenous EMT is not enough …
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Dynamics of Endogenous Cardiac Repair and Methods for Enhanced Post-Injury Cell Therapy
… resulting scar. Recent studies revealed modest cardiac regeneration occurring throughout life and accelerating (albeit insufficiently) post-injury. However, the magnitude is contested with some studies indicating low cardiomyocyte formation and others indicating rapid formation of increasingly …
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Danio rerio (Hamilton, 1822) širdies ir kraujagyslių sistemos vystymosi ir regeneracinių mechanizmų tyrimai /
… investigation of cardiovascular development and regeneration. However, conditional mutagenesis, which is essential for dissecting a role of developmental genes in regeneration, has not been demonstrated in the adult zebrafish. This remains a main disadvantage of D. rerio model system. The main …
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Studying the mechanisms of cardiovascular development and regeneration in Danio rerio (Hamilton, 1822) /
… investigation of cardiovascular development and regeneration. However, conditional mutagenesis, which is essential for dissecting a role of developmental genes in regeneration, has not been demonstrated in the adult zebrafish. This remains a main disadvantage of D. rerio model system. The main …
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac damage. Previous high throughput screening studies …
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miR-322/503 Cluster Drives Cardiac Differentiation by Inhibiting CUG-binding Protein 1
Understanding the mechanisms of early cardiac fate determination may lead to better approaches in promoting heart regeneration after injury. MicroRNAs (miRNAs) involved in the process are particularly interesting due to their small profile and relatively shorter path to clinic. With Mesp1 as the …
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mIGF-1 regulates heart physiology and induces complete regeneration of infarcted myocardial tissue
… to prevent or reverse the devastating effects of cardiac damage have met with limited success, presumably due to restricted cardiac regenerative potential. We tested the ability of a locally acting mIGF-1 isoform to regenerate the injured heart, restricting expression of a mIGF-1 transgene to the …
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PRIMING CARDIOVASCULAR STEM CELLS FOR TRANSPLANTATION USING SHORT-TERM HYPOXIA
… or conditions that will promote cardiovascular regeneration across all age groups. A pretreatment, such as short-term hypoxia, and concurrent implementation of a novel progenitor, such as those that co-express Isl-1 and c-Kit, may enhance the results reported in clinical trials completed to …
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Investigating the role of macrophages in larval zebrafish heart regeneration
… can completely regenerate their hearts after cardiac injury via dedifferentiation and proliferation of surviving cardiomyocytes. Macrophages are a required cell type for successful zebrafish heart regeneration and so may offer a roadmap to the optimisation of human myocardial repair. However, …
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BNC1 Regulates Human Epicardial Heterogeneity and Function
… form coronary smooth muscle cells and cardiac fibroblasts, and instruct cardiomyocytes to proliferate and mature. Adult mammalian epicardium is quiescent, but reactivates post-injury with limited effect. However, in zebrafish and in neonatal mouse, epicardial signalling enables robust …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
… potential to engraft and differentiate into cardiac myocytes following transplantation into the infarcted heart. However, the ability of TIMP-1 to activate endogenous stem cells and enhance their differentiation into cardiac regenerative cell types is still unknown. We postulate that TIMP-1 …
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Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
… are crucial effectors and modulators of cardiac repair following myocardial infarction (MI). Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse MI outcomes. An attractive therapeutic strategy to treat acute inflammatory disorders, such as MI, …
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