Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"cardiac myocytes"”.
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
… heart contractility and rate. β2AR also has a cardiac protective role through utilizing multiple mechanisms to reduce receptor signaling. This includes β2AR desensitization, β2AR coupling to Gαi, and β2AR degradation, all of which are tightly regulated by post-translational modifications of the …
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The Effects of Cocaine and Ecstasy on Cardiac Myocytes and the Intact Myocardium
… homeostasis and normal heart function. Cultured cardiac myocytes (H9c2) and New Zealand White rabbits (Oryctolagus cuniculus) were used to measure the responses to various concentrations of cocaine or ecstasy at both the cellular and intact organ system levels. We observed that cocaine and …
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The myocyte enhancer factor-2 (MEF2) family mediates complex gene regulation in skeletal and cardiac myocytes
… of acute Mef2 knockdowns in neonatal cardiomyocytes and uncovered a requirement for MEF2A and -D, but not MEF2C in cardiomyocyte survival. Comparative microarray analysis confirmed that, similar to skeletal myoblasts, the MEF2 family regulated distinct but overlapping gene programs in …
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Modulation of calcium channel expression in cardiac myocytes of rats during growth hormone-induced growth or normal postnatal development
Voltage-dependent Ca$\sp{2+}$ currents of cardiac myocytes were studied using patch-clamp techniques. T-type Ca$\sp{2+}$ current density of atrial myocytes was found to be positively correlated with the plasma growth hormone levels and the growth rate of atrial myocytes in normally developing …
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Sphingosine-1-Phosphate and Fingolimod (FTY720) Regulate ICl,swell In HL-1 Cardiac Myocytes via Intracellular Binding And Mitochondrial ROS Production
… current that plays an important role in cardiac electrical activity, cellular volume regulation, apoptosis, and acts as a potential effector of mechanoelectrical feedback. Persistent activation of ICl,swell has been observed in models of cardiovascular disease. We previously suggested …
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Thick filament regulation of myocardial contraction
… governed by mechanisms intrinsic to individual cardiac myocytes. The experiments in this dissertation were designed to examine the effects of sarcomere length and thick filament protein isoform expression on the contractile properties of single skinned cardiac myocytes. Myosin binding protein-C …
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Characterization of the Dynamic Mechanical Properties of Single Cardiovascular Cells
… are exposed to complex strains during the cardiac cycle in vivo. Strains can change as a result of disease and surgical interventions necessitating tissues to mechanoadapt to maintain function. Biomechanical models provide insight into tissue behavior and disease progression that can be …
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
… and neurohumoral signaling are common causes of cardiac hypertrophy. These extrinsic stress stimuli typically act on GPCR and induce a cascade of signal transduction to re-program terminally differentiated myocytes to grow in length or width. The compensatory hypertrophic response can enhance …
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How to Mend a Broken Heart: Massive Endocytosis and the Role of Lipidic Forces in Membrane Trafficking
… significance in isolated cells and intact cardiac tissue. These non-canonical forms of membrane trafficking are related to perturbations within the outer lipid monolayer of the plasmalemma or through coupled calcium-mediated fusion and phosphatidylinositol 4,5-bisphosphate (PIP2) signaling. …
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Calcium Channel Gamma(6) Subunits Are Unique Modulators of Low Voltage-Activated Calcium Current
… and regulation of AMPA receptor targeting. Cardiac myocytes express three gamma subunits, gamma 4, gamma6 and gamma7, whose function(s) in the heart are unknown. Here we compare the effects of the previously uncharacterized gamma 6 subunit with that of gamma4 and gamma7 on the low …
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Calcium Influx via the T-Type Calcium Channel Plays a Permissive Role in Proliferation of Mouse Embryonic Hl-1 Cells
Cardiac myocytes express two types of voltage operated calcium currents, a high voltage activated (HVA) L-type, and a low voltage activated (LVA) T-type. Influx of calcium into the cell through the L-type channel is responsible for excitation-contraction coupling in the heart. The T-type calcium …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… structural and biochemical alterations at the cardiac cell level. Early stage cell alterations include hypertrophy, calcium mishandling, cell apoptosis, excessive ROS production, and increased collagen production by fibroblasts. Eventually, major structural and functional changes can appear in …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
… potential to engraft and differentiate into cardiac myocytes following transplantation into the infarcted heart. However, the ability of TIMP-1 to activate endogenous stem cells and enhance their differentiation into cardiac regenerative cell types is still unknown. We postulate that TIMP-1 …
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The effects of aging on cardiac mechanics
… the hypothesis that the mechanical properties of cardiac myocytes significantly change with aging thereby contributing to the LV diastolic dysfunction. Cellular mechanical properties were determined by indenting cells with an atomic force microscope (AFM). The indentation results were interpreted …
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Entwicklung und Anwendung eines Expressionsklonierungssystems in primären Kardiomyozyten - Identifizierung von Translin als neuem Target der Herzinsuffizienz
… of an expression cloning system in primary cardiomyocytes - Validation of Translin as a new target for heart failure Congestive heart failure continues to represent a life threatening disease with unmet medical need. Functional impairment of the insufficient heart is reflected in altered geometry …
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Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action
… auxiliary subunits, gamma is least understood. Cardiac myocytes express three gamma isoforms: gamma4, gamma6 and gamma 7. Low-voltage activated (LVA) calcium currents regulate rhythmic activity and cell proliferation in the heart. Previous studies using heterologous expression systems showed …
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Quantitative analysis of subcellular biomechanics and mechanotransduction
… passive cytoskeletal mechanics in adult mouse cardiac myocytes. Finally, we studied cells deficient in the nuclear envelope
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Mutations in Connexin43 and Connexin40 Associated with Human Atrial Fibrillation; Physiology and Mechanism
… Fibrillation (AF), the most common sustained cardiac arrhythmia, is a disease that affects the electrical conductance in the atria. Gap junction channels, composed of connexin (Cx) proteins, allow the electrical signal to propagate between cardiac myocytes. Mutations in two highly expressed …
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