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Showing 1 to 11 of 11 for “"cardiac myocyte"”.
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Mathematical modelling of energy demand and supply in the cardiac myocyte
… heart muscle are crucial for maintaining normal cardiac function, yet they are not very well understood. Although a number of mechanisms have been proffered by which mitochondrial supply of ATP can change to match varying workload in the myocardium, identifying the underlying regulatory pathways …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
Cardiac remodeling with associated changes in myocardial structure and function occurs in response to injury to the heart concomitant with chronic hypertension. The structural changes to the heart, including myocyte and vascular hypertrophy as well as interstitial and perivascular fibrosis, are …
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KDM4D Overexpression Enhances Cardiac Regeneration and Mitigates Myocardial Damage in Response to Ischemic Injury
Protection of myocardium as a means to retain cardiac muscle after injury and prevent the development of heart failure has eluded the field for decades. We recently reported that lysine demethylase KDM4D could partially prevent and reverse cell cycle gene silencing, resulting in modest adult …
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Cellular pathways of angiotensin II signalling in the hypertrophic myocardium
… intra-cellular signalling of the hypertrophic cardiac myocyte. Ventricular hypertrophy in the Dahl SS/Jr (Dahl S) rat was dependent upon the time on 6% NaCl diet. This was confirmed to be partly based on differences in viable myocyte size as determined by Fluorescence Activated Cell Sorting …
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Modeling oxygen requirements in ischemic cardiomyocytes
… one or more arteries are obstructed and the cardiac muscle is deprived of oxygen. Although removing the blockage and allowing reperfusion can prevent death, at the same time it can cause significant damage through "reperfusion injury." To date, there are limited methods to predict the …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… structural and biochemical alterations at the cardiac cell level. Early stage cell alterations include hypertrophy, calcium mishandling, cell apoptosis, excessive ROS production, and increased collagen production by fibroblasts. Eventually, major structural and functional changes can appear in …
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Characterization of the Dynamic Mechanical Properties of Single Cardiovascular Cells
… are exposed to complex strains during the cardiac cycle in vivo. Strains can change as a result of disease and surgical interventions necessitating tissues to mechanoadapt to maintain function. Biomechanical models provide insight into tissue behavior and disease progression that can be …
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Defining a role for the cystic fibrosis transmembrane conductance regulator in the heart
… of CFTR affects neonatal ventricular cardiomyocyte contraction rate. We found that CFTR is involved in the regulation of both baseline and beta-adrenergic stimulated contraction rate. Additionally, loss of CFTR activity, whether acutely or chronically, leads to modulation of intracellular …
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Sphingosine-1-Phosphate and Fingolimod (FTY720) Regulate ICl,swell In HL-1 Cardiac Myocytes via Intracellular Binding And Mitochondrial ROS Production
… current that plays an important role in cardiac electrical activity, cellular volume regulation, apoptosis, and acts as a potential effector of mechanoelectrical feedback. Persistent activation of ICl,swell has been observed in models of cardiovascular disease. We previously suggested …
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… Pivotal to the age-associated alterations in cardiac phenotype is a decline in the proliferative capacity of cardiac myocytes (CMs), which is insufficient to compensate for the basal rate of CM death over time. The terminally differentiated nature of adult CMs also underlies the inability of …
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Mechanismen der Urocortin-II-induzierten Stimulation der NO-Produktion in isolierten Kaninchen-Ventrikelmyozyten
Urocortin II (UcnII) ist ein Peptid aus der Corticotropin-Freisetzungs-Faktor (CRF) Familie. UcnII verbessert die Herzfunktion im Gesunden und in der Herzinsuffizienz. In Kardiomyozyten ruft UcnII ein cAMP und Ca2+-abhängigen positiv Inotropen und Lusitropen Effekt hervor. Ziel dieser Studie war es …