Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"cardiac isoform"”.
-
Nuclear respiratory factor 1: a novel inhibitor of the human gene promoter of the cardiac isoform of acetyl-coenzyme a carboxylase
… fatty acid (FA) transfer enzyme. Upstream, the cardiac-enriched isoform of acetyl-CoA carboxylase (ACCl3) synthesises malonyl-CoA, a potent inhibitor of CPT-1 and FA 13-oxidation. Since ACCl3 induction elevates malonyl-CoA levels, we hypothesised that AMPK activates NRF-1 thereby inhibiting …
-
Contribution of troponin-I to the regulation of cardiac muscle
… regulates striated muscle contraction. The cardiac isoform of TnI (cTnI) has a ~30 residue N-terminal extension, which contains two serines (Ser22/23) that become phosphorylated by protein kinase A upon \(\beta\)-adrenergic stimulation. However, the function of the N-terminus of cTnI remains …
-
Mitophagy in Heart Failure: A Selective Autophagic Degradation of Mitochondria
… in remodeling of the myocardium in a variety of cardiac pathologies. Autophagy can be either non-selective or selective for damaged protein aggregates or organelles. Reactive oxygen species (ROS) generated in mitochondria causes mitochondrial permeability transition (MPT) and induces selective …
-
Camkii-Mediated Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor at Serine-150 Results in Decreased Channel Activity
… in various cell types including regulating cardiac gene expression. Recent results from our lab have shown that the predominant InsP3R isoform in the heart, the InsP3R2, is primarily targeted to the nuclear envelope in ventricular myocytes. Here it forms a macromolecular complex with the …
-
Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease
… contributor towards the development of various cardiac pathophysiologic conditions. Therefore, studies attempting to delineate undenying mechanisms driving cardiac metabolic remodeling represent an important initiative toward the development of novel therapeutic interventions. To further …
-
Physical Mechanisms of Ca-ATPase Regulation in the Heart
… relaxation. The focus of this research is the cardiac isoform of the Ca-ATPase which undergoes allosteric regulation by the phosphoprotein phospholamban (PLN). The Ca-ATPase is thought to be a target for nitrative stress and is affected by several chronic diseases of the heart. In the heart, …
-
In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… to facilitate this. Located in both skeletal and cardiac muscle, junctin has a short N-terminal domain (Njun) and bulky, highly charged C-terminal domain (Cjun), that are exposed to the cytoplasm and SR lumen respectively. Although originally thought to function as a linker between the SR calcium …
-
In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… to facilitate this. Located in both skeletal and cardiac muscle, junctin has a short N-terminal domain (Njun) and bulky, highly charged C-terminal domain (Cjun), that are exposed to the cytoplasm and SR lumen respectively. Although originally thought to function as a linker between the SR calcium …