Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"cardiac ischemia"”.
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
… 5 (PDE5) inhibitors are cardioprotective against ischemia/reperfusion (I/R) injury. However, it remains uncertain if I/R affects PDE5. We hypothesized that generation of reactive oxygen species (ROS) during I/R leads to upregulation of PDE5, which contributes to pathological changes following …
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Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
… likewise, demonstrated the ability to exacerbate cardiac ischemia reperfusion (I/R) injury. We hypothesized that pulmonary exposure to AgNP induces cardiovascular toxicity in the form of expanded I/R injury, electrical dysfunction and inducing a persistent increase in circulating proinflammatory …
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INVESTIGATION OF INOSINE AND HYPOXANTHINE AS BIOMARKERS OF CARDIAC ISCHEMIA IN PLASMA OF NON-TRAUMATIC CHEST PAIN PATIENTS AND A RAPID ANALYTICAL SYSTEM FOR ASSESSMENT
… 2-5% of these patients are experiencing acute cardiac ischemia, but due to the shortcomings of current test methods, they are incorrectly diagnosed and discharged without appropriate treatment provided, thus leading to poor patient outcome and potential medical malpractice litigation.The goals …
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THE EFFECTS OF MYOCARDIAL INFARCTION ON NEUROINFLAMMATION: FOCUS ON THE ROLE OF EXTRACELLULAR VESICLES
… a collection of diseases, most importantly cardiac ischemia. Complications following cardiac ischemia represent a significant risk factor that threatens the patient’s quality of life in both short and long terms and affect many body organs, such as the brain. Many research studies …
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
… forms of PM is capable of inducing expansion of cardiac ischemia-reperfusion (I/R) injury. These mechanisms include mitochondrial dysfunction, alterations in vascular reactivity, and increased sensitivity to cytokine mediated inflammation. Following exposure to silver nanoparticles (AgNP) or …
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
… work is to determine how mitochondria impact cardiac ischemia/reperfusion (I/R) injury, and to identify potential mechanisms to therapeutically target. The studies within were conducted on treadmill-trained male rats, ex vivo heart preparations, isolated/cell cultures, and isolated …
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Myocardial metabolism and ischemia assessed by microdialysis. Clinical and experimental studies in cardiac surgery
… methods to study myocardial metabolism and ischemia show considerable limitations when employed during and after cardiac surgery. Microdialysis is a technique for continuous sampling of substances from the interstitium. It has been extensively used in experimental settings in the heart but …
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Kinetics study of heat shock protein 70 expression
… 70 (HSP70) is well known for its efficacy in cardiac ischemia protection. The purpose of this study was to determine HSP70 expression kinetics in response to mild thermal stress. Currently there are no comprehensive experimental HSP70 expression kinetics data available. An efficient …
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The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection
… homeostasis. Moreover, HAX-1 level is reduced in cardiac ischemia/reperfusion injury, implicating the participation of HAX-1 in this disease. Thus, to elucidate the role of HAX-1 in the regulation of calcium kinetics and cardioprotection, HAX-1 over-expression and HAX-1 heterozygous deficient …
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Role of KATP channels in angiogenesis
… in situations characterized by tissue-damaging ischemia where blood supply is severely reduced, such as lower limb diabetic arteriopathy or following myocardial infarct. In contradistinction, stemming excessive or ectopic angiogenesis can be beneficial in situations such as solid tumor growth or …
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Development of a cardiac patch for the regeneration of infarcted hearts
The inflammation that occurs after cardiac ischemia/reperfusion leads to high levels of oxidative stress, which produces deleterious effects that ultimately limit regeneration of the myocardium. This stress response can be prolonged, thereby affecting various stages of cardiac repair remodelling. …
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Monotherapie mit Wachstumsfaktoren am porcinen Modell chronischer Myokardischämie : eine Evaluation anhand der globalen Herzfunktion und der Koronarangiographie
Einleitung: An einem porcinen Modell der chronischen myokardialen Ischämie wurden die Wirkungen unterschiedlicher intramyokardialer Wachstumsfaktortherapien auf die globale Herzfunktion untersucht. <br>Methoden: Eine Woche nach Anlage einer hochgradigen RIVA-Stenose an Schweinen Deutscher Landrasse …