Global ETD Search
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Showing 1 to 19 of 19 for “"cardiac glycosides"”.
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BIOSYNTHESIS AND FUNCTION OF CARDIAC GLYCOSIDES IN THE CRUCIFER GENUS <i>ERYSIMUM</i>
… of a different group toxic compounds called cardiac glycosides or cardenolides. Cardiac glycosides have been used to treat heart conditions for hundreds of years and are on the World Health Organization's list of essential medicines. However, the biosynthetic pathway remains unknown. In …
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The Preparation of ß-[5-(p-Hydroxyphenyl)-Cyclohexahediohe-1,3]-Alanine
… in structure and functional groups to the cardiac glycosides.
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The Preparation of 5-(2',3',4'-Trimethoxyphenyl) -4,6,-Dicarbeth-Oxycyclohexanedione-1,3 and Derivatives
… of a great interest in substances resembling cardiac glycosides found in the digitalis plant. Fieser and Strain had accumulated all the work done up to that time on the structures, purification, extraction and essential functional groups of these substances. |As one would expect, the next step …
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The Preparation of Polyhalogen, Polyhydroxy, and Other Derivatives of 4-(p-Hydrqxyphenyl)-Cyclqhexanediqne-3,5.
… aroused at that time in substances resembling cardiac glycosides found in the digitalis plant. Fieser and Strain have compiled all the work that had been done up to that time on the extraction, purification, structure and essential functional groups of these substances. Attempts were also made …
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Studies in cholestrol metabolism
… corticosteroids, the vitamins D and the cardiac glycosides. In sharp contrast are certain sterols, exemplified in the animal kingdom by cholesterol - familiar, abundant, easily determined, yet singularly obscure in their physiological significance. In some restricted fields the functions …
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Derivatives of 1-(3-methoxy-4-acetoxyphenyl)-2,6-dicarbethoxy-cyclohexanedione-3,5
… for the further synthesis of substitutes for cardiac glycosides (IV) and hormones because they have the necessary functional groups in proper locations.|Papadakis and Scigliano have also synthesized 1-(3-Methoxy-4-acetoxyphenyl)-2,6-dioarbethoxy-cyclohexane- dione-3,5 (VII). They reacted …
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Searching for Anticancer Agents and Antimalarial Agents from Madagascar
… from Bussea sakalava (Fabaceae); four new cardiac glycosides from Leptadenia madagascariensis Decne. (Apocynaceae); two new and four known alkaloids from Ambavia gerrardii (Baill.) Le Thomas (Annonaceae); five new sesquiterpene lactones from Polycline proteiformis Humbert (Asteraceae). The …
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In vitro anti-platelet aggregation activity of the extracts of bulbine natalensis
… revealed the presence of anthraquinones, cardiac glycosides, saponins, tannins, flavonoids and alkaloids. The hexane extract revealed the highest contents of total phenols (5.028 mg/g); flavonoid (3.293 mg/g) and proanthocyanidin (2.565 mg/g). Hexane extract also displayed the highest ABTS …
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The screening of medicinal plants traditionally used to treat diarrhoea, in Ongoye area, KwaZulu Natal.
… alkaloids, flavonoids, soponins, anthraquinones, cardiac glycosides and tannins. Most of the plant extracts showed high antibacterial activity against most of the tested micro-organisms with the diameter of inhibition zones ranging between 10 and 30 mm. Of the plants studied, the most active …
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Antimicrobial activity testing of traditionally used plants for treating wounds and sores at Ongoye area KwaZulu-Natal, South Africa
… alkaloids, flavonoids, saponins, anthraquinones, cardiac glycosides and tannins. The following plants were the most effective against the micro-organisms tested: Gunnera perpensa, Hypericum aethiopicum, Hypoxis hemerocallidea, Lippia javanica, Pentanisia prunelloides, Trichilia dregeana and …
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Pharmacogenetic analysis of admc polymorphisms affecting the efficacy of TB treatment in tuberculosis patients from Tanzania and Uganda, and pharmalogical evaluation of potent medicinal plant extracts used in the treatment of tuberculosis
… to determine the presence of alkaloids, cardiac glycosides, terpenoids, and tannin compounds in all plant species. Antioxidant activity was evaluated qualitatively and quantitatively using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric ion reducing power (FRAP) assays, respectively. The …
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Cytotoxicity and anti-mycobacterial activities of sclerocarya birrea and Dodonae viscosa anguistifolia against MTB strain
… screening showed the presence of saponins, cardiac glycosides, steroids, terpenoids and tannins. The BEA solvent system revealed more bands than the CEF solvent system while the EMW solvent system was the least efficient. LCMS method showed sufficient revolving power to separate isomeric …
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Investigating ethnopharmacology-based natural product leads for antimalarial drug discovery
… including tannins, flavonoids, saponins and cardiac glycosides amongst others in both the aqueous and methanolic extract of B. ferruginea. Anthocyanins were found present in the methanolic extract only. Further investigation of the mechanism of action of the methanolic B. ferruginea extract …
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Antibacterial activity of the crude extract and fractions of spirostachys africana against multi-drug resistant bacteria
… flavonoids, alkaloids, steroids, saponins, cardiac glycosides and terpenoids in most of S. african’s test samples. Fraction F1 and F2 both lacked alkaloids and saponins. The micro-plate dilution assay demonstrated that the MCE and all its fractions can inhibit the growth of all selected MDR …
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Endogenous cardioactive substances in blood: effects on the isolated guinea-pig atria
… isoprenaline, 5-hydroxytryptamine and cardiac glycosides. After ultrafiltration on Amicon diaflo membranes (XM100A and PM30A) activity was found solely in the retentate fractions. The ultrafiltrates were devoid of positive inotropic and chronotropic actions. Since the molecular weight …
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Antiplasmodial/Antipyretic activity of some Zulu medicinal plants
… terpernoids, flavonoids, anthroquenones, cardiac glycosides; alkaloids (the major active constituents of most antimalarial drugs) were also observed in A. australe which, amongst others, exhibited the most in vitro antiplasmodial activity. The plant extracts either killed or reduced …
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Investigation of cellular mechanisms underlying insulin-releasing or glucose-lowering effects of extracts of selected plants used in traditional medicinal practice for the management of diabetes
… alkaloids, tannins, anthraquinones, saponins, cardiac glycosides and phlobatannins within aqueous C. Procera seed extracts and a majority of these phytochemicals found within the other C. procera extracts. Aqueous J. tanjorensis leaf extracts displayed the most phytochemicals out of the J. …
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Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta Graveolens L. in mice and rats
… graveolens indicated the presence of alkaloids, cardiac glycosides, flavonoids, saponins, tannins and triterpene steroids. The HPLC fingerprint indicated characteristic peaks at the following retention times; 1.654 min,2.271 min, 2.403 min, 4.705 min and 7.691 min. The LD50 obtained for Ruta …
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Physiological Role of the α<sub>2</sub>-Isoform of the Na, K-ATPase in the Regulation of Cardiovascular Function
… Cre recombinase in a smooth muscle and cardiac-specific manner. </p><p>Using the SM22α Cre we generated a smooth muscle-specific knockout (SMα<sub>2</sub><sup>-/-</sup>) mouse with a 90% reduction in α<sub>2</sub>-expression in heart and vascular smooth muscle. Interestingly, tail-cuff …