Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"cardiac fibrosis"”.
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
… have been removed from the market due to fibrosis and heart valve regurgitation. We hypothesized that there is an intrinsic cardiac dopaminergic system and changes to that system can lead to left ventricular (LV) remodeling and particularly, cardiac fibrosis. The first aim focused on …
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The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis
… of 1, 2, 4, 8, 12, and 14 weeks. Changes in cardiac physiology were assessed at respective time points via echocardiography. Additionally, the use of histological techniques, mRNA analysis, apoptosis determination, and immunohistochemistry were employed to determine the functional and …
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Human immunodeficiency virus (HIV)-mediated cardiac fibrosis: implication of cellular immunomodulation and cytokine profile alterations
… global health concern among this population. Cardiac fibrosis, a contributor to both CVD onset and progression, varies by region, with non-ischemic cardiomyopathy predominant in sub-Saharan Africa (SSA) and ischemic cardiomyopathy prevalent in high-income countries. Few mechanistic studies, …
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Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
… heterogeneity in which maladaptive cardiac fibrosis, in both the right and left ventricles of the heart, plays a unique role in the manifestation of disease. Fibrotic remodeling quantified in this project occurs in a chamber-dependent manner on both sides of the heart. Extracellular …
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Cardiac Fibrosis and Ventricular Arrhythmogenesis: Unravelling the influence of fibrosis on electrical dysfunction in the development of heart failure
… by significant structural remodelling such as fibrosis (Ma 1998; LeGrice et al. 2012). While structural remodelling is a hallmark of progression towards HF, its role in arrhythmogenesis remains an area of debate. With this in mind, the principal objectives of this study were to characterise the …
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The role of Nox2 containing NADPH oxidase in hypertensive heart disease
… reported to be involved in the development of cardiac hypertrophy and fibrosis. However the relevant cellular source(s) involved in the above effects remains unclear. The aim of this thesis was to investigate the critical cell source of the Nox2 in a model of angiotensin II (AngII) induced left …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
… condition characterized by myocardial fibrosis and cardiac dysfunction in diabetic patients. The resolution of myocardial fibrosis to improve cardiac function in diabetes is an active area of research. Notably, increased T lymphocyte infiltration into myocardium has been attributed to …
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Determining if the Developmental Origin of Cardiac Fibroblasts Determines the Fate of Activation in Adult-Onset Hypertension
… worldwide, responsible for 1 in5 deaths, with cardiac fibrosis playing a critical role in heart failure progression [13, 18, 17]. Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition and tissue stiffening, impairs cardiac function, reducing contractility and …
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The impact of erythropoietin on uraemic cardiomyopathy
… weeks prior to sacrifice at a dose of 30 μg/Kg. Cardiac function was assessed in vitro in the perfused heart and in vivo using an arterial pressure catheter. Cardiac metabolism was analysed using 13C NMR along with the activity and protein expression of key metabolic enzymes. In a separate set of …
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… had no beneficial effects in reducing the cardiac remodeling and mitochondrial biogenic defects in chagasic mice. SIRT1 agonist, however, controlled the NFB signaling of oxidative and inflammatory responses and helped preserve the left ventricular function in chagasic mice. We also found …
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RUOLO DELLA STIMOLAZIONE VAGALE SULLA PROLIFERAZIONE DEI FIBROBLASTI CARDIACI IN VIVO IN MODELLO ANIMALE DI FIBRILLAZIONE ATRIALE.
Introduction: Cardiac fibrosis is a pathological response that causes abnormalities in cardiac conduction and mechanical function, thereby contributing to the pathophysiology of a variety of cardiac conditions, including hypertrophy, failure, and arrhythmias. Atrial fibrillation (AF) is the most …
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… inhibits its contractile function and leads to a cardiac output loss. Cardiac fibroblast and myofibroblast cells are integral in the remodelling of injured tissue and are the most anticipated therapeutic target for cardiac fibrosis. To date, there is no anti-fibrotic therapy, which we argue, is …
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Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
… Ang II infusion in cPLA2α+/+ mice increased cardiac and renal cPLA2 activity, resulted in cardiovascular and renal dysfunction, caused cardiovascular remodeling, endothelial dysfunction, increased vascular reactivity and compromised renal hemodynamics in cPLA2α+/+ mice; these changes were …
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Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
… of mutant SHP2 on contractile performance and cardiac fibrosis. We found that 4-month-old DMD hearts with the SHP2 mutation have similar diastolic and systolic function compared to DMD hearts without the SHP2 mutation. However, there was a trend towards improved diastolic function in SHP2: …
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Consequences of Endogenous Mitochondrial Oxidative Stress in the Heart
… values. Additionally, these mice show severe cardiac fibrosis and decreased FECH activity in cardiac tissue. The long-term goal of this project will be to carry out next-generation sequencing on single cardiomyocytes isolated from both Sod2 knockout and wild-type mice. However, a necessary …
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Elucidating the role of LARP6 in cardiovascular remodeling
… and fluid overload create a distinct milieu of cardiac stressors. To compensate, the heart undergoes a period of necessary structural remodeling. However, chronic/excess remodeling disrupts tissue homeostasis and creates an environment that can exacerbate cardiac dysfunction. Therefore, …
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New Advances on the Biochemical Pathways in the Reninangiotensin System in Hypertension and their role in Cardiac Structure and Function
… disease and heart failure are hyperension and cardiac hypertrophy. Although the incidence of heart disease has been declining since 1999, it is still the number one killer accounting for 27% of all deaths in the United States in 2005, the latest year for which data are available. Moreover, …
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Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure
… Protein acetylation is an important regulator of cardiac metabolism and SIRT3 is protective in heart disease. The underlying pathophysiology of heart failure in FRDA is unclear. I suspect that increased acetylation in FRDA heart mitochondria damages cardiac energy homeostasis by inhibiting …
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Hypoxia, Lipid Signalling and Tissue Metabolism in Obesity-Related Metabolic Disease
… obese liver, in contrast to that of lean rats. Cardiac metabolism was more resilient to both hypoxia and obesity, suggesting the liver may be the metabolic “first hit” for these stresses. Mice fed a high-fat high-sugar diet showed a whole-body switch away from glucose towards fatty acid …
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