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Showing 1 to 14 of 14 for “"cardiac fibroblast"”.
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Defining the Developmental Signals of the Cardiac Fibroblast
Cardiac fibroblasts play a central role as a mediator of inflammatory and fibrotic response and also secrete extracellular matrix components that provide structural support for regeneration and remodeling of the wound. Despite the importance of the cardiac fibroblast in heart disease, very little …
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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function
… receptor is highly expressed in macrophages and cardiac fibroblasts, cells which play key roles in inflammation and healing following myocardial infarction (MI). A<sub>2B</sub>R have been shown to induce collagen production and promote organ fibrosis, although the reports of A<sub>2B</sub>R role …
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
Coronary vascular smooth muscle cells (cVSMC) and cardiac fibroblasts are essential for coronary artery development and are important mediators of myocardial pathogenesis. These cells form when a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and migrates into …
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ROLE OF CIRCULAR PVT1 IN ISCHEMIC HEART FAILURE
… circPVT1 expression significantly increased in cardiac fibroblasts after TGF-β1 treatment. circPVT1 silencing attenuated the levels of pro-fibrotic markers induced by TGF-β1, highlighting a pro-fibrotic role of circPVT1. RNA pull-down assays confirmed the interaction between circPVT1 and three …
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Estrogen Modulation of Cardiac Immune Cells Is Cardioprotective.
… myocardium, suggesting estrogen may modulate the cardiac immune cells. The cardiac immune cells have been linked to adverse remodeling responses that occurs secondary to chronic volume overload. Therefore, to test if estrogen was modulating the cardiac immune cells; the cardiac immune cells of …
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… inhibits its contractile function and leads to a cardiac output loss. Cardiac fibroblast and myofibroblast cells are integral in the remodelling of injured tissue and are the most anticipated therapeutic target for cardiac fibrosis. To date, there is no anti-fibrotic therapy, which we argue, is …
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Development of a cardiac patch for the regeneration of infarcted hearts
The inflammation that occurs after cardiac ischemia/reperfusion leads to high levels of oxidative stress, which produces deleterious effects that ultimately limit regeneration of the myocardium. This stress response can be prolonged, thereby affecting various stages of cardiac repair remodelling. …
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Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
… strain and stress) is constantly applied to the cardiac extracellular matrix (ECM) at the cellular level (i.e. myocyte contraction and/or fibroblast focal adhesions) or globally through hemodynamic pressures. While mechanical load can be an important factor in maintaining tissue homeostasis, …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
… We hypothesized that there is an intrinsic cardiac dopaminergic system and changes to that system can lead to left ventricular (LV) remodeling and particularly, cardiac fibrosis. The first aim focused on determining the relative gene expression of all five dopamine receptors in both wild …
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Gold nanorods: Applications in chemical sensing, biological imaging and effects on 3-dimensional tissue culture
… modified gold nanorods have on the behavior of cardiac fibroblasts in tissue culture. As an alternative to solution-based techniques in Raman spectroscopy, we have found that a sandwich architecture in which a surface assembled monolayer (SAM) of 4-mercaptobenzoic acid (4-MBA) is sandwiched …
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Lrg1 in preeclampsia and heart failure: role as a biomarker and mediator of disease
… compared to patients who died from non-cardiac issues. No significant difference was found between control and patients with left ventricular hypertrophy. We then studied the functional association of LRG1 with the migration of human cardiac fibroblast cells and found that recombinant …
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Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury
… receptors in this effect. Methods: H9C2 cardiac fibroblast cells were subjected to simulated ischemia by exposure to 1mM H₂O₂ following a 30min pre-treatment with 75ng/L (dietary concentration), 1μM (pharmacological concentration, 0.232mg/L) melatonin or/and 75mg/L (dietary concentration) …
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Analysis of signal transduction pathways and the cytoskeleton in VASP-deficient cell lines and mouse models
… plasma membrane activity and random motility in fibroblast. In order to study the physiological function of VASP, VASP-deficient mice had been generated in the laboratory by homologous recombination. VASP-/- mice showed hyperplasia of megakaryocytes in the bone marrow and spleen and a two-fold …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
Cardiac remodeling with associated changes in myocardial structure and function occurs in response to injury to the heart concomitant with chronic hypertension. The structural changes to the heart, including myocyte and vascular hypertrophy as well as interstitial and perivascular fibrosis, are …