Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"cardiac electrophysiology"”.
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Image guidance in cardiac electrophysiology
Cardiac arrhythmias are characterized by a disruption or abnormal conduction of electrical signals within the heart. Treatment of arrhythmias has dramatically evolved over the past half-century, and today, minimally-invasive catheter-based therapy is the preferred method of eliminating arrhythmias. …
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Sex Differences in Cardiac Electrophysiology
… a male bias and there is more work to be done. Cardiac conduction is a highly synchronized process. Electrical signals are passed cell to cell through two mechanisms, ephaptic coupling and gap junctional coupling. These methods of electrical communication rely on gap junctions, sodium channels …
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Noninvasive Multi-Modality Studies of Cardiac Electrophysiology, Mechanics, and Anatomical Substrate in Healthy Adults, Arrhythmogenic Cardiomyopathy, and Heart Failure
… electrical function of heart muscle cells or the cardiac conduction system. Electrocardiographic Imaging (ECGI) is a noninvasive modality for imaging cardiac electrophysiology. By combining recordings of the voltage distribution on the torso surface with anatomical images of the heart-torso …
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An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells
… link between hyperglycaemia and impaired foetal cardiac electrophysiology is poorly understood. Using a cardiac developmental cellular model, this study aimed to explore the effects of hyperglycaemia on the autorrhythmicity of mouse embryonic stem cell (mESC)-derived cardiac-like cells.
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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
… models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter 1 presents an overview of cardiac anatomy, relevant physiology, and cardiac electrophysiology computational models. Chapter 2 provides a basic explanation of optogenetic …
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Chronic Circadian Disruption Alters Behaviour, Cardiac Function and Glucose Regulation in Mice
… glucose after glucose or insulin bolus, altered cardiac electrophysiology, increased cardiomyocyte size, and an increase in anxiety-like behaviours. Circadian disruption from social/work schedules or disorders in people is often confounded with other unhealthy habits. The present study …
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Modeling Action Potential Propagation During Hypertrophic Cardiomyopathy Through a Three-Dimensional Computational Model
… asymptomatic and first manifests itself during cardiac arrest, making it a challenge to diagnose in advance. Computational models can explore and reveal underlying molecular mechanisms in cardiac electrophysiology by allowing researchers to alter various parameters such as tissue size or ionic …
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Synchronous rhythms in coronary heart disease: an hypothesis concerning the anomalous nature of some common ventricular arrhythmias - investigation with an electronic analogue
… formulated on the basis of existing knowledge of cardiac electrophysiology. These are simulated on purpose-built electronic analogues in order to investigate their arrhythmic properties which are compared to the characteristics seen earlier in ECGs. It is concluded that two of these particular …
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Electrophysiologic Characterization of the Arrhythmogenic Substrate in Reentrant Atrial and Ventricular Arrhythmias Insights from the Clinical and Experimental Electrophysiology Laboratories
… of 11 publications of clinical and translational cardiac electrophysiology research that has been executed over the last seven years. The focus of this dissertation and the selected papers is on the use of electroanatomic mapping technology to define the arrhythmogenic substrate in patients with …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
… β subunits. While much of the field of cardiac electrophysiology and pathology has focused on treating and preventing cardiac arrhythmias by targeting the α subunit, there is also evidence that targeting the β subunits, particularly SCN1B, the gene that encodes β1 and an alternatively …
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Effects of Perfusate Composition (Na+ and Ca2+) on Cardiac Electrical and Mechanical Function in the Isolated Langendorff-Perfused Heart
… found that elevating sodium actually depresses cardiac mechanical function. This is both in a pre- and post-ischemic setting. In short, we show that electrolyte variation may influence both cardiac electrophysiology and contraction; however, an improvement in one does not guarantee an …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell death and altered gene expression. Mitochondrial dysfunction and HF are common complications of chronic treatment from diverse groups of drugs, in particular anticancer drugs …
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Interplay between Ephaptic and Gap Junctional Coupling in Cardiac Conduction
Sudden cardiac death occurs due to aberrations in the multifactorial process that is cardiac conduction. Conduction velocity (CV) and its modulation by several determinants, like cellular excitability, tissue structure and electrical coupling by gap junctions (GJ), have been extensively studied. …
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Extracellular Spaces and Cardiac Conduction
… decades of research and thousands of studies on cardiac electrophysiology, cardiovascular disease remains among the leading causes of death in the United States today. Despite substantially beneficial advances, we have largely shifted cardiovascular disease from an acute to a chronic issue. It is …
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A study of phase resetting, mutual entrainment, and modified ventricular parasystole using a model of coupled heart cells
Several aspects of cardiac electrophysiology including phase-resetting and entrainment are investigated through the dynamic interactions of coupled mathematical models of cardiac cells. Unlike previous studies of cell interaction which have used simplified models of a general cardiac cell or …
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The Molecular Anatomy of Mitochondrial Disease: Identification and Characterisation of Novel Nuclear-Encoded Mitochondrial Disease Genes
… in heart and skeletal muscle, and abnormal cardiac electrophysiology. Recombinant AAV-mediated expression of wildtype, human TMCO6 rescued the CI deficiency and electrophysiological function of 3 month-old knockout mice hearts. In contrast, stable expression of the patient mutant protein …
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Effects of Perfusate Solution Composition on the Relationship between Cardiac Conduction Velocity and Gap Junction Coupling
… has been examined for experiments concerning cardiac electrophysiology. Specifically, multiple labs have found differences in results when comparing cardiac conduction velocity (CV) between healthy mice and mice that were heterozygous null for the gap junction (GJ) forming protein, Connexin …
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Arrhythmia mechanisms in acute ischaemia and chronic infarction in rabbit heart
… and the occurrence of arrhythmias. The electrophysiology of the epicardial surface of isolated hearts was examined using the voltage sensitive dye RH237 and optical action potentials were recorded from a 13x13mm area of left ventricular epicardium using a 16x16 element Hamamatsu …
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The interrelationship between central sleep apnea and atrial fibrillation
… A total of 153 patients, originally seen at the cardiac electrophysiology clinic at Beth Israel Deaconess Medical Center and subsequently offered home sleep apnea testing, were included in this study. Several databases – home sleep apnea testing results, polysomnography reports, electrocardiogram …
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