Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"cardiac contractility"”.
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The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection
… homeostasis. Moreover, HAX-1 level is reduced in cardiac ischemia/reperfusion injury, implicating the participation of HAX-1 in this disease. Thus, to elucidate the role of HAX-1 in the regulation of calcium kinetics and cardioprotection, HAX-1 over-expression and HAX-1 heterozygous deficient …
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Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy
… on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state …
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Cardiovascular Toxicity Induced by Fumonisin in Pigs and Horses
… B1, we demonstrated that fumonisin B1 decreases cardiac contractility, heart rate, cardiac output, and mean arterial pressure, and increases mean pulmonary artery pressure and pulmonary artery wedge pressure in pigs. The onset of hemodynamic changes was temporally associated with increases in …
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The Role of MCL-1 in the Heart: Gateway from Life to Death
… of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we have demonstrated that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy preceded by loss of myofibrils and cardiac contractility, abnormal mitochondria …
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Tracking autonomic balance using open and closed loop models of the arterial baroreflex
… rate, vascular resistance, venous tone, and cardiac contractility. Accurate quantitative models of the baroreflex would provide physiological insight, and could allow for real-time tracking of ANS activity in clinical settings. Prior work has concentrated on modeling the baroreflex …
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Defining Ankyrin-b Syndrome: Characterization of Ankyrin-b Variants in Mice and Men and the Discovery of a Role for Ankyrin-b in Parasympathetic Control of Insulin Release
… is associated with both the benefits of enhanced cardiac contractility and the costs of arrhythmia, early senescence, reduced lifespan, and impaired glucose tolerance. This constellation of traits is known as ankyrin-B syndrome, which may have important implications for humans possessing …
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… intracellular signaling pathways regulates cardiac remodeling (a general determinant of HF). The ability of signalosomes (molecular signaling complexes) to compartmentalize several cellular pathways has been recently established. One example of these signalosomes is a family of scaffolding …
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The Identification and Pharmacological Characterisation of Novel Apelin Receptor Agonists In Vitro and In Vivo
… was active in vivo, producing an increase in cardiac contractility and vasodilatation, similar to apelin. These effects were achieved without receptor desensitisation, supporting the remarkable G protein bias observed in vitro. Furthermore, it was disease-modifying in vitro in an endothelial …
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Valutazione degli aggiustamenti cardiocircolatori nel motociclismo classe enduro
Hemodynamic parameters, such as Cardiac Output (CO) and Stroke Volume (SV), have never been studied in motorcycle racing. Probably because the measurement of these variables is hampered by difficulties related to the particular environment of motorcycle performance, which can be considered an …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… remodeling process that initially maintains cardiac function, but ultimately becomes maladaptive. The signaling pathways that drive cardiac remodeling are extremely complex and poorly understood, and therefore, a better understanding of the mechanisms involved in the development and …
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Myosin structural dynamics: mechanistic insights and therapeutic technology developments
… a putative heart failure therapeutic, increases cardiac contractility. My results demonstrate that OM stabilizes myosin’s pre-powerstroke structural state and significantly slows the actin-induced powerstroke. I also used transient biochemical and structural kinetics to elucidate the molecular …
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Cardiovascular function in animal models of metabolic syndrome and type 2 diabetes : the role of inducible nitric oxide synthase (iNOS)
… function in these disorders. Blood pressure, cardiac contractility, cardiac index, regional flow, vascular resistance and venous tone were measured in diseased as well as normal rats. Biochemical analyses such as activities of iNOS, immunostaining of iNOS and western-blot analysis of iNOS in …
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Optimizing pharmacodynamics and evaluating echocardiographic effects of alfaxalone sedation in bearded dragons (Pogona vitticeps) and prairie rattlesnakes (Crotalus viridis)
… Echocardiography evaluated whether the cardiac function of either species was significantly affected by alfaxalone administered at the optimal dose and route of administration. End systolic volume was the only echocardiographic parameter that significantly increased in bearded dragons …
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Role of PERM1 in the Development of Insulin Resistance and Diabetic Cardiomyopathy During High-Fat Diet Feeding
… predominantly expressed in skeletal and cardiac muscle. Our group has previously demonstrated that PERM1 is downregulated in both human and mouse failing hearts, and that Perm1-knockout mice exhibit reduced cardiac contractility and energy reserve. However, the role of PERM1 in cardiac …
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In-vivo- und In-vitro-Untersuchungen zur myokardialen Kontraktilität vergleichend an Weißen-Neuseeland-Kaninchen und Chinchilla-Bastard-Kaninchen
… is to be examined based on parameters of cardiac contractility. To determine the morphometric parameters and the contractile function of the heart, six animals at a time anaesthetized with Propofol are examined by means of echocardiography. As a result the thickness of the heart wall and …
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The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… in these parameters are not known. OFRs depress cardiac function and contractility and produce tissue injury. We hypothesized that decreases in cardiac function and contractility, and cellular injury during endotoxemia are due to increased levels of OFRs because of increased production and/or …
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Contractile Properties of Striated Muscle in Development and In Disease
… it presents in clinic is difficult. Muscle contractility can be studied directly, and the use of multiple assays has allowed me to examine muscle development and disease at the protein, subcellular, and cellular level. Distal arthrogryposis is a skeletal muscle birth defect that can be …
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Novel Systems Physiology Instrumentation: Addressing Limitations in Heart Failure Reseearch
… failure is one of the most common and costly cardiac diseases in developing and industrialized countries. Despite its important public health implications, no definitive cure exists for heart failure patients. An important reason for this is a wide array of symptoms in heart failure: loss of …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… transcription factor involved in development of cardiac structure and cardiomyocyte differentiation, has been shown to increase in response to in utero VPA exposure. Furthermore, this increase in gene expression has been associated with contractile dysfunction and myocardial disorganization. To …
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Assessment of Cardiac Function by Acoustic Radiation Force (ARF) Based Methods of Ultrasound Elastography
… filling efficiency resulting in diminished cardiac output. Cardiovascular researchers have been attempting to develop tools for assessment of cardiac function for decades. Evaluating cardiac function helps clinicians to diagnose and to follow the progress of HF patients. </p><p>The gold …
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