Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1313 for “"carcinoma"”.
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Differentiating follicular thyroid carcinoma from the follicular variant of papillary thyroid carcinoma
… follicular adenoma (FA), follicular thyroid carcinoma (FTC) and follicular variant of papillary thyroid carcinoma (FVPTC) remain a diagnostic challenge in some cases. This is as a result of the assessment of nuclear features being highly subjective, and the threshold for confirming …
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MOLECULAR PROFILING OF UROTHELIAL CARCINOMA
… was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used to study …
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Chemoradiation in advanced vulval carcinoma
Vulval carcinoma is uncommon, affecting approximately 2 per 100 000 women annually. The treatment of choice is radical vulvectomy and inguinal lymph node dissection. ‘Advanced’ vulval carcinomas involve midline structures (such as clitoris, urethra or anus) and/or adjacent pelvic organs or bone, …
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RNA Therapeutics for Fibrolamellar Hepatocellular Carcinoma
<p>Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer characterized by a recurrent fusion of the heat shock protein DNAJB1 and the catalytic subunit of protein kinase A (PRKACA). Due to limited efficacy of conventional treatments such as chemotherapy and radiation my work explored …
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Radioresistance in oral squamous cell carcinoma
Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer accounting for approximately 6% of all cancers worldwide. However the distribution across the globe varies considerably. The majority of small tumours of the oral cavity and upper aerodigestive tract, in the absence of …
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PRMT5 Inhibitors in Merkel Cell Carcinoma
Merkel Cell Carcinoma (MCC) is a rare neuroendocrineskin cancer. Treatment options are limited, and they are largely based on MCC’s similarity to other cancers, rather than original research. Many of these treatments have low efficacy and significant side effects, and the overall prognosis remains …
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Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy
Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver …
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The Role of Platelets In Ovarian Carcinoma
… thrombocytosis associated with ovarian carcinoma remains unknown and were the focus of the current study. Following IRB approval, patient data were collected on 619 patients from 4 U.S. centers and used to test associations between platelet count at initial diagnosis, clinicopathologic …
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Understanding The Pathogenesis of Renal Medullary Carcinoma
<p>Renal medullary carcinoma (RMC) is a lethal cancer that predominantly affects young individuals with sickle cell trait (SCT). It is not currently understood why RMC only affects certain individuals with SCT. We found that patients with RMC more frequently participated in high-intensity exercise …
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Pathologic Markers of Prognosis In Ampullary Carcinoma
<p>Ampullary cancer is a rare gastrointestinal malignancy that can be curable with surgical resection of localized disease. The benefit of adjuvant therapy, however, remains unknown in these patients partly because of difficulty in stratifying which patients are at high risk for recurrence. To …
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Surrogate endpoints of survival in metastatic carcinoma
In most randomised controlled trials (RCTs), a large number of patients need to be followed over many years, for the clinical benefit of the drug to be accurately quantified (1). Using an early proxy, or a surrogate endpoint, in place of the direct endpoint of overall survival (OS) could …
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Carcinoma tiroideo, ambiente vulcanico e metalli pesanti
… indicano un aumento dell’incidenza del carcinoma tiroideo nelle aree vulcaniche, dove bassi livelli di inquinamento da metalli pesanti contaminano i residenti. Per la maggior parte di questi metalli non sono disponibili dati relativi al loro effetto sulla ghiandola tiroidea. Questa tesi …
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
… to determine the role of THRs in hepatocellular carcinoma development. Using the Resistant-Hepatocyte model (RH model) of rat hepatocarcinigenesis, we found downregulation of THRβ1 and THRα1 in most of early preneoplastic lesions and of HCCs. THRβ1 and, to a lesser extent, THRα1 downregulation …
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Analysis of Exome Sequencing in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the type of cancer difficult to classify and analyze despite the high occurrence, because it displays a high level of tumor heterogeneity with complex etiology. For unbiased analysis of HCC with diverse tumorigenic backgrounds, a genomewide study that does not …
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Gastric remnant carcinoma : histochemical and immunohistochemical profile
Gastric remnant carcinoma (GRC) is a gastric cancer that develops in gastric remnant more than five years after resection for benign disease. GRC comprises 1 %-9% of all gastric cancers. Partial gastrectomy for peptic ulcer is thought to be a risk factor for GRC. Pancreato-duodenal and bile reflux …
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Mechanisms of Reversible Sorafenib Resistance in Hepatocellular Carcinoma
… approved treatment for advanced hepatocellular carcinoma (HCC) patients. Its efficacy is further hindered by intrinsic (upfront) and acquired drug resistance (initial response and subsequent relapse) and a lack of alternative therapies. Our laboratory previously demonstrated using a human …
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
… control in the contemporary era, nasopharyngeal carcinoma (NPC) patients still suffer from a significant risk of distant metastasis (DM). Thus, developing methods to better identify and treat NPC patients at risk of DM is of paramount importance. MicroRNAs (miRNAs) have been shown to provide …
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Identifying Metabolic Liabilities in Hürthle Cell Thyroid Carcinoma
… respiration for tumor growth. Hürthle cell carcinoma of the thyroid (HTC) represents an outlier wherein HTC tumors enrich for mitochondrial DNA mutations that are predicted to impair complex I of the electron transport chain (ETC). Consistent with these mutations, our work shows that HTC …
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