Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"carcinogenicity"”.
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Mechanisms of toxicity and carcinogenicity of three alkylanilines
Alkyl-substituted anilines have been implicated as important etiological agents in human carcinogenesis. Specifically, 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3EA) have been associated with an increased risk of human bladder cancer, independent of cigarette …
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The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium
Recent epidemiological data has indicated that chronic exposure to metals such as arsenic and cadmium increases the risk of cancer and other diseases. These metals may have negative biological effects on cells by disrupting homeostatic cellular processes and altering normal signal transduction. One …
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A Review of Perfluorooctanoic Acid Carcinogenicity and Application to Human Risk
Perfluorooctanoic acid (PFOA) is a synthetic organic chemical that consists of an 8 carbon alkyl chain with a terminal carboxyl group in which the carbon-hydrogen bonds have been replaced with carbon-fluorine bonds except at the terminal carboxyl end. This perfluoralkyl carboxylate is a …
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Investigation of in Silico Modelling to Predict the Human Health Effects of Cosmetics Ingredients
… to assess the current in silico profilers for carcinogenicity (both genotoxic and non-genotoxic), mutagenicity and skin sensitisation through assessment using multiple high-quality experimental databases. The research presented herein demonstrates the ability to assess the positive predictivity …
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Risk factors for oesophageal cancer in Uruguay
… to assess whether the effect is related to the carcinogenicity of the plant or the high temperature at which maté is consumed. In addition the effect of diet, alcohol drinking and tobacco smoking on oesophageal cancer risk was assessed.
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CYTOTOXIC EVALUATION OF SOME MANNICH BASES OF CONJUGATED STYRYL KETONES
… cells. In addition, over a long period of time, carcinogenicity, mutagenicity and resistance may develop. These problems necessitate the development of new anticancer drugs which could target biomolecules other than nucleic acids and which should have different chemical available medication. To …
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Integration of Toxicity Data from Experiments and Non-Testing Methods within a Weight of Evidence Procedure
… this dissertation, (i) two new structure-based carcinogenicity models, (ii) ToxDelta, a new read-across model for mutagenicity endpoint and (iii) a genotoxicity model for the metal oxide nanoparticles are introduced. Within the latter section, best professional judgement method is employed for …
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C8-Arylguanine Modified Hairpin Oligonucleotides: Synthesis, Conformational Analysis, and Tools for the Investigation of Z-DNA Formation
… how DNA adduct formation is related to their carcinogenicity. Previous work in our lab has demonstrated that the formation of C8-arylguanine DNA adducts, derived from arylhydrazines, shifts the B /Z DNA equilibrium toward the Z-DNA conformation in d(CG)5 sequences. However, our previous work …
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Inducing Liquid Evaporation with Hygroscopic Gels
… there is no concrete evidence to prove the carcinogenicity of aluminum, various studies have also shown that long exposure to aluminum can lead to breast cancer in women. Hence there is a potential need to find aluminum-free alternatives for antiperspirants. Consumers are also showing an …
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Advancing Toxicology-Based Cancer Risk Assessment with Informatics
… Monte Carlo simulations performed with a carcinogenicity potency database to estimate the overall carcinogenic risk of a mixture of genotoxic compounds showed that structural similarity would not likely increase the overall cancer risk. A cancer risk model was developed for genotoxic …
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Enhanced polymeric nanoparticles for gene delivery
… trials due to toxicity, immunogenicity, and carcinogenicity has been tragic and strongly motivates a non-viral approach. However, non-viral gene delivery is currently ineffective. Here, we show that polymeric nanoparticles composed of poly([beta]-amino esters) (PBAEs) and DNA can be …
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Investigation of the genotoxic potential of the marine biotoxins okadaic acid and azaspiracids
… been published on possible long term effects, carcinogenicity and genotoxicity. To investigate genotoxicity in the present study, DNA fragmentation was detected using the COMET assay. In contrast to most other available studies, two further endpoints were included. The Trypan Blue Exclusion …
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Effects of Calcium Cyclamate on the Immune Response in Rabbits
… rather than the effects that possibly initiate carcinogenicity.
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Regulatory issues concerning the preclinical testing of synthetic peptides
… single and repeat dose toxicity, genotoxicity, carcinogenicity, reproductive and developmental toxicity, and often studies for impurities.</p>
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Impact of waste plastics on asphalt concrete chemical and environmental characteristics
… related to blood pressure, skin irritation, and carcinogenicity. A cradle-to-grave comparative LCA results demonstrated that the environmental impacts of an AC mix incorporating recycled plastics are highly dependent on the method of incorporation of waste plastics. However, the availability and …
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The development of welding fumes health risk assessment tool for automotive component related industries
… respiratory toxins, target organ toxins, and carcinogenicity) and the related technical characteristics were determined by using quality function deployment approach. Personal samplings of welding fumes were conducted in Plant 1 and 2 to assess the concentration of metal constituents during …
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Novel Roles of the Aryl Hydrocarbon Receptor in Normal Physiology and Epigenetic Reprogramming
… TCDD exposure in laboratory animals is linked to carcinogenicity, hepatic steatosis, and a lethal wasting syndrome. In recent years, AhR knockout and antagonism have been reported to confer resistance to western diet induced obesity as well as reversing diet induced obesity. Together, these …
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Investigation of Hexavalent Chromium Reduction by Aerobic Bacteria in Water and Soil
… Agency because of its high toxicity and carcinogenicity. Cr(VI) is commonly used in electroplating, pigment, leather processing and mining resulting in widespread Cr(VI) pollution, and a need for the development of cost-effective remediation technologies. Microbial reduction of Cr(VI) to …
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Computational approaches to predicting drug induced toxicity
… following endpoints were modelled: mutagenicity, carcinogenicity, inhibition of the hERG ion channel and the associated arrhythmia - Torsades de Pointes. A consensus model was developed based on Derek for WindowsTM and Toxtree and used to filter compounds as part of a collaborative effort …
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