Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 126 for “"carcinogen"”.
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… is the leading cause of cancer death worldwide. Carcinogen inflicted malignancies, including tobacco smoking derived lung adenocarcinoma, harbor thousands of mutations per genome. Over the last decades many new lung adenocarcinoma oncogenes have been identified and thus new anticancer agents have …
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Molecular mechanisms of the carcinogen chromium(VI)-induced DNA-protein crosslinking in cultured intact human cells
… crosslinking is implicated in chromium Carcinogenicity. However, the mechanism of chromate-induced DNA-protein crosslinking has not been established. Based on the current literature and our preliminary data, we hypothesized that Cr(VI)-induced DNA-protein crosslinks may, in part, be due …
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Investigation of the mechanism of mutagenesis by the DNA adducts of the human bladder carcinogen, 4-aminobiphenyl
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1992.
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The Effect of Ethanol and Acetaldehyde on Formation and Repair of Carcinogen-Dna Adducts in the Mammary Gland
… and acetaldehyde are capable of enhancing carcinogen-DNA adduct formation and inhibiting removal. However, these effects are dependent on the concentrations of ethanol or acetaldehyde, the time of exposure and the dose of carcinogen. Additionally, these effects, particularly those related …
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The Effect of the Carcinogen 20-methylcholanthrene on the Production of Vaccinal Viral Lesions on the Chorio-Allantoic Membrane of the Embryonated Egg
… been conducted to study the various effects of carcinogenic agents on laboratory animals. Some of the earlier works were devoted to observing the effect of certain carcinogens In relation to those viruses which had the ability to produce tumorous growths in experimental animals. It has been …
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Penetration of Carcinogen Across Porcine Esophagus and Applications of Disposable Pipette Extraction for Forensic Toxicology and Food Safety by Gas and Liquid Chromatography/Mass Spectrometry
<p>This dissertation focuses on the chemical analyses of N-nitrosonornicotine from (NNN) porcine esophageal tissue, benzodiazepines (BZDs) and steroids in urine, and toxins such as melamine and pesticides in various foods. The effects of menthol, ethanol and also acetaldehyde on the flux of NNN …
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Ozone-bromide-NOM interactions in water treatment
… bromate (BrO$\sb{3\sp{-}}$), a suspected carcinogen. Natural organic matter (NOM) reads with HOBr/OBr$\sp{-}$ to form organic bromine (TOBr).
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The effect of ethanol consumption on the development of the female rat mammary gland
… gland and are considered susceptible to chemical carcinogen action. Similarly, in the sexually-mature carcinogen-treated (NMU) rat, consumption of dietary ethanol was associated with a significant increase in carcinogen-sensitive TEB and TD structures and a concomitant decrease in …
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Synthesis of anion exchange/activated carbon fiber hybrid materials for aqueous adsorption of toxic hexavalent chromium
… chemical”, has recently been identified as a carcinogen by ingestion. Unfortunately, it is present in drinking water supplies in United States. An effective, Point-of-Use (POU) based technology to remove Cr(VI) in tap water is urgently needed to protect human beings against this carcinogen. …
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Rice preparation for cadmium and arsenic reduction while maintaining a healthy microbial load
… is a major source of exposure, globally, to the carcinogen and nephrotoxin cadmium and the carcinogen inorganic arsenic. As rice is a dietary staple, this makes rice production highly problematic. Thus, if cadmium and inorganic arsenic can be reduced in rice, even in rice based processed products …
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Synthesis of a Resveratrol Glycinate Derivative.
… resveratrol has had media attention as an anti carcinogen. However, the bioavailability of resveratrol is low in the human system due to its hydrophobic nature. Therefore, it must be administered in high dosages to be effective. A plethora of derivatives have been synthesized that have the …
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The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to dna damage and imbalanced repair
… of folate deficiency has been implicated in carcinogenesis, with the strongest evidence formulated in colon cancer. The role of folate in DNA repair, DNA synthesis and methylation reactions renders this nutrient an valuable target for studying the onset and progression of cancer. Using …
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Spatial Analysis of Atrazine in the Elm Fork Watershed
… potential environmental endocrine disruptor and carcinogen. Overall, concentrations were lower than the four-quarter drinking water average of 3 µg/Lthe Maximum Contaminant Level set by the USEPA. However, three creek stations had four-quarter average concentrations greater than 3 µg/L, and …
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Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic
… effects, in NHEK, of BaP, the most toxic and carcinogenic polycyclic aromatic hydrocarbon among the four, and arsenic, another high priority skin carcinogen. This work demonstrates that BaP and arsenic inhibit terminal differentiation in NHEK. Arsenic also decreases proliferation in a manner …
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The co-carcinogenic effect of topical vitamin A palmitate on 9, 10-dimethyl-1, 2-benzathracene (DMBA)-induced carcinoma in the buccal pouch of the syrian golden hamster
… hamster cheek pouch as a model for experimental carcinogenesis and to produce squamous cell carcinomas in this organ. For a number of reasons, the pouch is most suitable for sequential studies of carcinogenesis, and these include the fact that it is easily accessible and can be everted simply, …
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Induction and characterization of de novo methylation by benzo[A]pyrene in the cancer cell lines MCF-7 and MDA-MB-231
… to test the hypothesis that the well-known carcinogen, benzo[a]pyrene has epigenetic effects, specifically the ability to alter cytosine methylation patterns. MCF-7 and MDA-MB-231 human breast cancer cells were treated for a period of sixty days with 100 nM benzo[a]pyrene. The methylation …
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The effects of dietary protein intake by the dam and by the offspring on mammary gland development in young female rats
… index because they are the target tissue for the carcinogen 1,2 dimethylbenz(a)anthracene (DMBA) and the carcinogen N-ethyl-N-nitrosourea. Contralateral mammary glands from offspring at 56 and 161 days were analyzed for moisture, fat, protein, DNA, and RNA by sampling a 2 cm disc of mammary tissue …
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Transport of the Herbicide Atrazine on Suspended Sediments During a Spring Storm Event in Mammoth Cave, Kentucky
… on suspended sediments. Atrazine is a known carcinogen and endocrine disruptor and has been shown to be toxic at low environmental concentrations. Atrazine has the capacity to adsorb to soil particles, which in karst areas such as those found in south central Kentucky can be transported …
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