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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"carboplatin"”.
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Komplexkonjugate bioaktiver Flavonoide & Naphthochinone und Photoaktivierung von Carboplatin für Studien der intrazellulären Verteilung
… sich mit der intrazellulären Verteilung von Carboplatin (4), welche mittels Click-Reaktion vonstattengehen sollte. Die Darstellung des alkinmarkierten Carboplatinderivats 158 erfolgte bis zur Stufe des Dibromids 185. Hierzu wurde ausgehend von Dimethylmalonat (176) und Methylchloroformiat …
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Evaluation of the in vitro elution characteristics of carboplatin-impregnated calcium sulfate beads
… To characterize the elution of platinum from carboplatin-impregnated calcium sulfate hemihydrate (CSH) beads in vitro. Sample: Sixty carboplatin-impregnated CSH beads and 9 CSH beads without added carboplatin (controls) Procedures: Carboplatin-impregnated CSH beads (each containing 4.6 mg …
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Evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads as a local treatment option for feline injection site-associated sarcomas
… site-associated sarcoma (FISAS) cells to carboplatin concentrations generated by elution of carboplatin-impregnated calcium sulfate hemihydrate (C-I CSH) beads. Sample: Five immortalized cell lines from histologically confirmed, primary FISASs. Procedures: For each cell line, one 96-well …
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Validação de método bioanalítico para avaliação da influência da ivermectina e ciclofosfomida na farmacocinética (pk) da carboplatina: ensaio pré-clínico
… consequences. The objective is to validate the carboplatin analysis method in rat plasma and to evaluate the influence of cyclophosphamide on the pharmacokinetics of carboplatin in healthy rats (preclinical pilot test). We studied 24 Wistars rats, divided into three experimental groups: G1 - …
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FOLATE RECEPTOR TARGETED LIPOSOMES AS THE ENABLING TECHNOLOGY FOR THE DELIVERY OF CHEMOTHERAPEUTICS IN THE TREATMENT OF OVARIAN CANCER
… ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could present a viable treatment option for the FR over-expressing ovarian cancers. The aim of this thesis was to develop a folate receptor targeted liposomal formulation of carboplatin and to evaluate its …
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Effect of platinum chemotherapy on tumour infiltrating immune cells in metastatic ovarian cancer: Mechanistic insights and therapeutic applications
… cancer this thesis found that treatment with carboplatin upregulates NK cell activating receptor ligands, induced a pro-inflammatory phenotype and sensitised tumour cells to NK cell mediated cytotoxicity. *In vivo*, carboplatin therapy was dependent on the presence of NK cells and …
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Block and Graft Copolymers Containing Carboxylate or Phosphonate Anions
… acrylamide phosphonate copolymers to incorporate Carboplatin. The resulting complexes exhibited excellent anticancer activity against MCF-7 breast cancer cells which might be related to ligand exchange of the dicarboxylate group of Carboplatin with the phosphonic acid moieties in the copolymer. …
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Mistura (O2-O3) no tratamento integrado de cadelas com câncer de mama: perfil oxidativo e qualidade de vida
… undergoing conventional chemotherapy with carboplatin. Twenty -five dogs were selected and studied, all with histopathological diagnosis of malignant mammary neoplasia, divided into two experimental groups: GC, composed of carboplatin only (n = 11) and GO3 - consisting of the …
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Maleinimid-funktionalisierte wasserlösliche Derivate klinisch etablierter Zytostatika – albuminbindende Prodrugs für eine verbesserte Chemotherapie
… zu albuminbindenden CPT-, Bendamustin- und Carboplatin-Derivaten umsetzen. <br>Albuminbindende Prodrugs des Zytostatikums CPT zeigen eine gegenüber CPT bis zu 27fach gesteigerte Wasserlöslichkeit und binden schnell und selektiv an Humanserumalbumin (HSA), wie durch HPLC-Experimente belegt …
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Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
… of specific tumour mutations on the response to carboplatin, the current standard of care, and VSV∆M51, a promising OV candidate. After a study of genetically diverse models, constitutive KRas activation enhanced VSV∆M51 replication in-vitro and sensitivity in syngeneic in-vivo models. VSV∆M51 …
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Multifaceted computational modelling in pharmaceutical research and development
… and diffusion of doxorubicin, paclitaxel, carboplatin, and gemcitabine anticancer drugs and also drug combinations such as doxorubicin with carboplatin, paclitaxel with gemcitabine and carboplatin employing NUIG-4 metal-organic framework as drug delivery agents. In this chapter, the …
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The Use of Preclinical Models to Improve the Treatment of Retinoblastoma
… studies that the combination of topotecan and carboplatin was effective. However both drugs cause myelosuppression and therefore administrating both of these drugs systemically is not possible. An alternative effective therapy in the clinic was the use of a subconjunctival administration. We …
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… present an integrative multi-omics analysis of carboplatin-resistant A2780 ovarian cancer cells (A2780R) developed via stepwise drug adaptation, revealing pronounced mitochondrial and metabolic rewiring. A2780R cells display an 8.8-fold increase in carboplatin IC50 compared to parental A2780S …
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Combination Chemotherapy and In vivo Modeling of BRCA-deficient, High-grade Serous Ovarian Cancer
… of new therapeutic entities. The combination of carboplatin and olaparib resulted in profound synergism in BRCA-deficient high-grade serous ovarian cancer cell lines when carboplatin was administered at a higher molar ratio relative to olaparib. The combination achieved effective cytotoxicity by …
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Platinum-NGR A Peptide Targeting Conjugate Of Cisplatin: Design, Synthesis, And Efficacy In Breast Cancer Cells
… chemotherapeutic drugs, such as cisplatin and carboplatin, are one of the primary therapies employed in the treatment of breast cancer. Adverse side effects caused by untargeted drug delivery of these platinum drugs are often a cause for cessation or interruption of cancer treatment. New …
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Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
… the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin form similar adducts on DNA, only oxaliplatin is active in colorectal cancer. Human organic cation transporters hOCT1 and hOCT2 markedly increase oxaliplatin, but not cisplatin or carboplatin, accumulation and potency in …
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Ionic Copolymer-Magnetite Complexes for Magnetic Resonance Imaging and Drug Delivery
… diameters) were investigated. Cisplatin and carboplatin were used as sample drugs. The potentials of the magnetite-ionomer complexes as dual drug delivery carriers and magnetic resonance imaging agents were evaluated. An acrylate-functional poly(ethylene oxide) macromonomer and hexyl (and …
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Synthetic strategies to improve the cytotoxicity of platinum-based cancer therapeutics
… adapts it to a second generation platinum drug, carboplatin. Furthermore, a method to make mono- or bis- substituted conjugates is devised. Chapter three describes the tethering of a series of estrogen linkers to oxidized derivatives of carboplatin, in hopes of seeing increased toxicity in ER(+) …
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
… which mechanisms may be most relevant in HGSOC, carboplatin-resistant, paclitaxelresistant and dual carboplatin-paclitaxel-resistant CaOV3 and OV90 (HGSOC) cell lines, along with age-matched parental controls, were subjected to RNA sequencing. Our analysis identified genes and processes that may …
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Zirconium-based Metal-Organic Frameworks for Pleural Mesothelioma Therapy
… sarcomatoid histology. Current treatment using carboplatin and pemetrexed induces severe side effects and has limited improvement in the survival of mesothelioma patients (3 months). Here, we proposed a new drug delivery system (DDS) based on metal-organic frameworks (MOFs) for mesothelioma …
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