Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"carbonylation"”.
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Manganese-catalyzed carbonylation of alkyl iodides
… A general method for the manganese-catalyzed carbonylation of alkyl iodides while using a variety of nucleophiles was developed. The method concerns the alkoxy and amino carbonylation as well as the use of more unconventional nucleophiles such as thiols, azide and hydride. The method employs …
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Conversion du méthanol en éthanol par carbonylation suivie d'hydrogénolyse
… a aussi été testé. L'objectif secondaire est la carbonylation du méthanol en acétate. Cette étape a été réalisée en phase gazeuse où des rendements très élevés, soit plus de 2000 kg d'acétate de méthyle par kg de métal précieux à l'heure (kg AM kg métal précieux[indice supérieur h]), ont été …
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Identification and Quantification of Protein Carbonylation by Mass Spectrometry
… disease states. We finally investigate protein carbonylation in ischemic mouse heart mitochondria, and develop a quantitative method for detecting carbonylated protein in this system. The research is based on liquid chromatography/mass spectrometry (LC/MS), Western Blots, and enzymatic assay.
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A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams
… Over recent decades, palladium-catalysed C–H carbonylation reactions have emerged as a powerful means of introducing carbonyl motifs to organic molecules. This thesis describes the development of a general C–H carbonylation reaction of secondary aliphatic amines, which provides facile access …
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In-situ spectroscopic studies of the mechanism of solid super-acid catalysed methanol carbonylation
… annually, 80 % of which is produced by methanol carbonylation. Current industrial processes involve rhodium and iridium catalysed homogeneous reactions. The use of heterogeneous catalysts in the synthesis of acetic acid would offer several process advantages. This thesis explores Ru/Rh doped …
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Palladium-Catalysed Carbonylation of Aliphatic Amines and its Application in the Total Synthesis of Cylindricine C
… projects on the theme of catalytic C(sp3)–H carbonylation of secondary aliphatic amines. Chapter 2 describes the development of a general methyl C–H carbonylation of secondary aliphatic amines to form synthetically useful β-lactam building blocks. Amines exhibiting a range of substitution …
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Hydrogenase Models and Studies Based on Iron Carbonyl Chelate Complexes
… or iron powder. Such routes utilize oxidative carbonylation, reductive carbonylation, or comproportionation. The routes readily allow isotopic-labeling of model complexes with 57Fe for study by specialized techniques, e.g. Mossbauer or NRVS, generating new insights into [FeFe]- and Hmd-H 2ases. …
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Mass Spectroscopic Identification and Quantification of Protein Carbonyls
… the post-translational protein modifications, carbonylation has attracted a great deal of attention due to its irreversible and irreparable nature. Despite the fact that protein carbonylation is associated with a series of physiological and pathological processes, there are still issues to be …
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New strategies for the synthesis and functionalization of aliphatic amines
… The first Pd-catalyzed methylene β-C−H carbonylation of alkylamines to form substituted β-lactams is reported. Through the synergistic use of a Pd-catalyst and Xanpthos ligand, secondary amines underwent exclusive methylene β-C−H activation in high yields and diastereoselectivities. …
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Design and characterization of zeolite supported cobalt carbonyl catalysts
… found to be active in catalyzing the methanol carbonylation reaction and following thermolysis were also found to be active Fischer-Tropsch catalysts. Major products observed in the carbonylation of methanol were methyl acetate and an acetaldehyde dimethyl acetal. The supported cobalt catalyst …
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PALLADIUM-BASED SYSTEMS IN HOMOGENEOUS CATALYSIS: EXPLORING NITROGEN LIGANDS FOR CO-MEDIATED REACTIONS
… Furthemore, the use of guanidines as ligands in carbonylation and alkoxycarbonylation of olefins has been attempted.
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The production and synthetic utility of the dioxygenase-derived metabolites of substituted aromatics
… and para-substituted arenes. Palladium-catalyzed carbonylation methodology was developed to convert halogenated cis-dihydrodiol metabolites to the corresponding carboxylates and a comparison of the overall efficiency between the enzymatic and chemical methods of access was made. Some of the …
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Hydroesterification of 1-hexene
Hydroesterification is the carbonylation of an olefin and the successive addition of an alcohol or water yielding an ester or acid. A variety of soluble palladium complexes are widely used for the hydroesterification of olefins due to their high activity and selectivity. Branched and linear …
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Design of flow processes for C–H activation-type reactions
… set out to design a process for a C–H oxidative carbonylation. A kinetic study has shown that the reaction is CO-starved even at elevated pressures and that there is an optimal CO concentration. The turn-over number was increased from 8 to nearly 500. Two scalable processes were then developed. …
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Proteomics of Oxidative Stress Using Inducible CYP2E1 Expressing HepG2 Cells and 3T3-L1 Adipocytes as Model Systems
… acid increased the susceptibility to protein carbonylation. The carbonylated protein isolation procedure indicated the palmitic acid may induce more carbonylation than oleic acid, but greater efficiency in the isolation procedure is required for a confidant determination.
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Palladium(II)-Catalysed sp 3 C–H Functionalisation of Hindered Amines and its Application in Synthesis of Astemizole Analogues
The development of a palladium-catalysed C–H carbonylation of hindered secondary amines is described. Central to this strategy is the temporary conversion of simple ketones into hindered secondary amines that facilitates a sterically promoted palladium-catalysed C–H activation. A range of …
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The development of palladium-catalysts for organic synthesis
… Weinreb amides via Pd-catalyzed aminocarbonylation at atmospheric pressure is described. Electron-deficient, -neutral and -rich aryl bromides were all efficiently transformed to product. Furthermore, the process tolerates a wide variety of functional groups, is mild, and is …
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Gold(II) fluorosulfate derivatives and new gold(I) and platinum(II) carbonyl complexes
… of Au2+ (d9) for the first time. Reductive carbonylation of Au(SO3F)3 in HSO3F, followed by solvolysis of the product, Au(CO)S03F, in SbF5 in the presence of CO produced [Au(C0)2][Sb2F11], the first example of a linear binary carbonyl cation in a thermally stable isolable compound. The white …
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Applications of titanium-mediated reductive coupling and cyclocarbonylation reactions toward natural product synthesis
… value of tandem reductive cyclization - carbonylation reactions in the preparation of complex molecules but also the interesting stereoselectivity observed therein. The first part of this work employs the titanium-mediated cyclocarbonylation of tethered dienals for the synthesis of …
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Carbon monoxide-driven reductive organic transformations and precious metals recycling
… has been developed to effect the reductive carbonylation of aryl halides in moderate to good yield. In this reaction, water is the hydride source, and CO serves both as the carbonyl source and the terminal reductant through the water–gas shift reaction. The catalytic generation of the Rh …
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