Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"carbonic anhydrase IX"”.
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Thiazolidinone-isatin hybrids as multi-target anticancer agents
… the first project is focused on human carbonic anhydrase IX and XII, two targets that are present and consistently validated as markers of disease progression in hypoxic solid tumours. Therefore, considering that isatin and thiazolidinone could be considered as privileged scaffolds in …
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Structure, Function and Applications of Metal-Requiring Enzymes: Carbonic Anhydrase and Epi-Isozizaene Synthase
Cryptophane Biosensors for Targeting Human Carbonic Anhydrase Cryptophanes represent an exciting class of xenon-encapsulating molecules that can be exploited as probes for nuclear magnetic resonance imaging. A series of carbonic anhydrase-targeting, xenon-binding cryptophane biosensors were …
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Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment
… the release of the major pH regulatory enzyme, carbonic anhydrase IX (CAIX). Molecular studies revealed that CAIX in cells and in EVs can be substituted with specific glycosaminoglycan chains, defining CAIX as a part-time PG. These findings advance our understanding of the role of EV-dependent …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
… evaluation of specific hypoxic markers such as carbonic anhydrase IX and cupper transporters (Ctr-1 and ATP7B) was performed. In FaDu model we confirmed the same [64Cu]ATSM distribution at the two analyzed times, that is similar to that of [18F]FAZA. On the contrary, EMT-6 and PC-3 models showed …