Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"carbohydrate recognition"”.
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Chemical tools to probe carbohydrate recognition and glycoconjugate biosynthesis
In eukaryotes the assembly of complex glycoconjugate structures takes place in the endoplasmic reticulum (ER) and Golgi apparatus, where a number of specific membrane-bound glycosyltransferases transfer sugar moiety from soluble or lipid linked activated sugar nucleotides to variety of acceptors …
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Part I. Molecular tweezers: Role of preorganization and synthetic progress toward a water soluble tweezer. Part II. Progress towards an empirical approach to carbohydrate recognition
Part I. Three molecular tweezers have been synthesized to determine the role of preorganization in the host-guest complexation of these systems. The synthesis of these tweezers was accomplished by the reaction of their respective dibromo-pyrylium salts with an absolute ethanol/aqueous ammonium …
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Biophysical chemistry of lipopolysaccharide specific bacteriophages
Carbohydrate recognition is a ubiquitous principle underlying many fundamental biological processes like fertilization, embryogenesis and viral infections. But how carbohydrate specificity and affinity induce a molecular event is not well understood. One of these examples is bacteriophage P22 that …
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Expression Of Gal/galnac Lectin Of Entamoeba Histolytica In Transgenic Chloroplasts To Develop A Vaccine For Amebiasis
… with stools to start new cycle. The parasite recognition of the host glycoconjugates plays an important role in the pathogenesis. Therefore, the Gal/GalNAc lectin could be a possible vaccine candidate. The Gal/GalNAc lectin is composed of a 260-kDa heterodimer of disulfide-linked heavy (170 …
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Functional properties of galectin-3. Beyond the sugar binding.
… that galectin-3 does not require the functional carbohydrate recognition domain (CRD) for its endocytosis. In the second paper we used M2 macrophages to study how galectin-1 directs the endocytosis of hemoglobin-haptoglobin complex. Our results indicated that galectin-1 bound fraction of the …
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Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation
… Further, human and pig platelet surface carbohydrates were examined demonstrating significant differences in carbohydrates known to be involved with platelet homeostasis. Carbohydrate recognition domains of receptors responsible for platelet clearance Macrophage antigen complex-1 …
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Biophysical Studies of Pathogen Recognition by C-Type Lectins
C-type lectins are a prominent class of pathogen recognition receptors in the innate immune system. The three pathogen recognition lectins studied in this thesis are the mannose binding protein (MBP), the dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) and the dendritic cell-specific …
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Molecular Basis of Peptidoglycan Recognition by a Bactericidal Gut Lectin
… sequences that support calcium-dependent carbohydrate binding in other C-type lectins. Given these novel functions and the lack of structural clues, nothing was known about the molecular mechanisms by which RegIII family members recognize and bind to peptidoglycan. Furthermore, the …
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Effects of galectins and antibodies in HIV infection; Novel Assays
… to microscale. Galectin-8, a galectin with two carbohydrate recognition domains (CRDs), had high affinity for gp120 as well as the HIV receptor CD4. The N-terminal CRD mediated the strongest interaction with gp120. The results of the FAassay correlated well with binding of whole virions screened …
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The Role of CH–π Interactions in Protein-Carbohydrate Binding
Protein-carbohydrate binding is essential for biological processes, including cellular recognition and immune signaling. Binding is driven by several types of non-covalent interactions: hydrogen bonding, metal ion coordination, and the less well-understood CH–π interactions. CH–π interactions are …