Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"carbapenem resistance"”.
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Effects of Anaerobic and Aerobic Digestion at Mesophilic and Thermophilic Temperatures on the Quantity of Carbapenem Resistance Genes in Wastewater Sludge
Antibiotic resistance genes (ARGs) encode resistance against antibiotic drugs in bacteria. Carbapenem antibiotics are one of the last lines of defence against bacterial infections and carbapenem resistance genes (CRGs) accumulate in sludge during wastewater treatment. Anaerobic and aerobic …
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Acquired Carbapenemases in Gram-Negative Bacilli in Singapore
This thesis hypothesised that the increase in carbapenem-resistance in Gram-negative bacilli in Singapore is due to the introduction of global clones of carbapenemase-producing strains with the potential to cause outbreaks. The diversity of acquired carbapenemase genes in Singapore, their …
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Outer Membrane Porin Regulation among Different Sequence Types of Escherichia coli Clinical Isolates
… with the spread of β-lactam and fluoroquinolone resistance. However, the reasons for the global dominance of this clone are largely unknown. It has been suggested that the success of ST131 E. coli is due to the resistance and virulence genes it possesses. Additionally, E. coli can decrease the …
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Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya
… beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries globally and recently among Libyan combatants who have been transferred to European countries …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… infections with a remarkable ability to develop resistance to multiple antibiotics (multidrug-resistance, MDR) which makes it a highly troublesome pathogen in many hospitals around the world. Third-generation cephalosporins (such as ceftazidime) and carbapenems (such as imipenem and meropenem) …
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Characterisation of novel and complex mechanisms of antobiotic resistance using a proteomics approach
The problem of increasing rates of antibiotic resistance has become a global concern, particularly among multi drug resistant Gram-negative nosocomial pathogens. These organisms display non- susceptibility to the majority of routinely used antibiotics, causing infections which are more difficult to …
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Diversity of acinetobacter baumannii isolates from Egypt
… to its remarkable rapid acquisition of resistance mechanisms A. baumannii is an excellent example of genetic plasticity, with its ability to acquire and express resistance in plasmids and chromosome particularly to carbapenems The aim of this thesis is to look at the molecular …
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Burden, Etiology and Control of Hospital Acquired Infections in Intensive Care Units in Vietnam
… accounted for > 50% of HAI pathogens with carbapenem resistance rates of 89.2%, 55.7%, and 14.9% respectively. The presence of an invasive device was associated with significantly higher risk for HAI. <br></br><br></br> The incidence of VAP and VARI in 374 patients analysed as part of the …
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Regulation of Outer Membrane Porins in P. aeruginosa Strains Collected from Patients with Cystic Fibrosis
… P. aeruginosa is able to rapidly develop resistance to antibiotics and alter its cellular physiology and metabolism to successfully colonize, grow, and survive. These adaptations have been associated with specific outer membrane porins of P. aeruginosa and their ability to affect cell …
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Opportunities to measure and improve antimicrobial stewardship in the Irish hospital setting
Background: Antimicrobial resistance (AMR) is one of the most significant threats to public health and increasing levels of resistance among gram negative organisms, and levels of vancomycin-resistant Enterococcus faecium (VRE) are of concern across Europe and in Ireland. Antimicrobial stewardship …
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Identification of new therapeutic compounds against carbapenemase-producing Klebsiella pneumoniae using a novel agar-based high-throughput microarray compound screening approach
… Over the years, the pathogen developed resistance to most β-lactam antibacterial drugs used in clinical care. The most important of these drugs are carbapenems – a class of broad-spectrum antibiotics reserved for the treatment of infections caused by multidrug-resistant (MDR) bacteria. …
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Molecular Mechanisms of Antibacterial Resistance Among Pseudomonas aeruginosa: Multi-Drug Efflux Pumps and Their Interactions with Other Resistance Mechanisms
… of multi-drug efflux pumps belonging to the Resistance-Nodulation- Division family of exporters has been shown to contribute to both intrinsic and acquired resistance among Pseudomonas aeruginosa. These pumps are able to recognize and export diverse compounds including several classes of …