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Showing 1 to 20 of 34 for “"capsular polysaccharide"”.
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Pathways for Biosynthesis of a Bacterial Capsular Polysaccharide
Made available in DSpace on 2014-12-05T21:45:32Z (GMT). No. of bitstreams: 1 6000245.pdf: 4026261 bytes, checksum: 27b3d6f07849fe12ed2e253b6ff2f939 (MD5) Previous issue date: 1959
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Tolerant effect of type 111 pneumococcal capsular polysaccharide in rabbits
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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NMR characterisation of group b streptococcus capsular polysaccharide repeating units
… differentiated by their sialic acid-containing capsular polysaccharide. Capsular polysaccharides are the virulence factor for bacterial pathogens and the target for vaccine development, with multivalent polysaccharide-protein conjugate vaccines licenced against bacteria such as Neisseria …
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Molecular modelling of the Streptococcus pneumoniae serogroup 6 capsular polysaccharide antigens
… study of the structural characterization of the capsular polysaccharides of Streptococcus pneumoniae is conducted using Molecular Modelling methods. S.pneumoniae causes invasive pneumococcal disease (IPD), a leading cause of death in children under five. The serotypes in group 6 are amongst the …
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Synthesis of fragments of the capsular polysaccharide of <i>Neisseria meningitidis</i> (serogroup A) suitable for bioconjugation
… factor of this bacterium is the presence of a capsular polysaccharide (CPS) and apart from being an important surface antigen, also protects the bacteria cells against phagocytosis by the host’s immune defense. The CPS structure of the serotype A is the (1-6)-linked …
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Characterization of the Capsular Polysaccharide of Haemophilus parasuis and its Application in the Diagnosis and Prevention of Glasser's Disease
… Our goals were to characterize the H. parasuis capsular polysaccharide (CP), determine its role in serotype-specificity and virulence, determine if CP is immunogenic, and develop diagnostic and protective products to prevent rampant H. parasuis infection within swine herds. Material from H. …
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The capsular polysaccharide of Actinobacillus pleuropneumoniae serotype 5A: role in serum resistance and characterization of the genetic basis for expression
… pleuropneumoniae synthesizes a serotype-specific capsular polysaccharide (CP) that protects this bacterium from host defenses. In the presence of anti-CP IgG, encapsulated A. pleuropneumoniae K17 was killed in precolostral calf serum (PCS) but not in normal serum used as a complement source. In …
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Detection of Actinobacillus Pleuropneumoniae and Identification of Serotypes 1, 2, and 8 by Multiplex Polymerase Chain Reaction
… 1, 2, and 8. Primers specific to the conserved capsular polysaccharide export region of A. pleuropneumoniae serotype 5 amplified a 880 bp fragment in all serotypes excluding serotype 4 or a 489 bp DNA fragment in all serotypes including serotype 4. Primers specific to the capsular polysaccharide …
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Environmental bacteriophages infecting Dickeya and Serratia species: receptors and diversity
… to nutritional stress, however disruption of the capsular polysaccharide cluster did not significantly impact virulence. Experiments assessing capsular polysaccharide as a putative receptor for Ackermannviridae family phages in nosocomial pathogen Serratia produced inconclusive results. …
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Progress in the synthesis of stabilized glycoconjugate vaccine candidates against Neisseria meningitides group A
… agents of meningitis in Sub-Saharan Africa. Its capsular polysaccharide antigen consists of a homopolymer of a-(1
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Antimicrobial Carbohydrate Vaccines: Development of Burkholderia pseudomallei immunogens
… experiments in mice have demonstrated that the capsular polysaccharide (CPS-1) of B. pseudomallei, which is composed of β-1,3-linked 6-deoxy-D-manno-heptopyranose residues, is a promising candidate for vaccine development. This thesis set out to explore routes to potential vaccine candidates for …
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Genetic analysis and phenotypic characterization of Lon mutants of Escherichia coli K-12
… polypeptide degradation and regulation of capsular polysaccharide biosynthesis) are differentially expressed in Lon⁻ strains. A direct correlation exists between the intracistronic ordering of the lon⁻ alleles and the degree of expression the Lon⁻ phenotypes in each strain. All isogenic …
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Novel strategies to prevent and treat experimental pneumococcal disease
… The adult pneumococcal vaccine is composed of capsular polysaccharide from 23 of the most prevalent disease causing serotypes. Purely polysaccharide vaccines are unable to protect those most at risk; infants under the age of two. This has led to the development of a paediatric conjugate …
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Bacterial colonization of the nasopharynx in paediatric patients with acute respiratory viral symptoms
… against the most clinically significant capsular serotypes. Initially, vaccination involved those at greatest risk, such as indigenous Australians and those with chronic diseases and other underlying risk factors. More recently, universal vaccination was introduced for children, using …
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IgG subclasses, specific antibodies and immunoglobulin allotypes in children with invasive Haemophilus influenzae type B and Staphylococcus aureus infections
… influenzae type b polyribosylribitol phosphate capsular polysaccharide antibodies; IgG, IgG1 and IgG2 S. aureus teichoic acid antibodies and G1m(f), G2m(n) and Km(3) allotypes were successfully established. Where possible the assays were standardized with reference sera and specimens were …
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Genomic diversity in naturally transformable Streptococcus pneumoniae
… resistance mechanisms and its evasion of capsular polysaccharide based vaccines through serotype replacement and capsular switching, all reflect the extensive diversity and plasticity of the genome of this naturally transformable organism which can readily alter its genome in response to …
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ΜΕΛΕΤΗ ΠΑΡΑΜΕΤΡΩΝ ΕΓΚΕΦΑΛΟΝΩΤΙΑΙΟΥ ΥΓΡΟΥ ΣΕ ΘΕΡΑΠΕΙΑ ΠΕΙΡΑΜΑΤΙΚΗΣ ΜΗΝΙΓΓΙΤΙΔΑΣ ΑΠΟ HAEMOPHILUS INFLUENZAE TYPE B
… THE FIRST PART THE ROLE OF HIB CAPSULE AND LIPOPOLYSACCHARIDE IN THE INDUCTION OF MENNIGEAL INFLAMMATION WERE EVALUATED. A MINIMAL INFLAMMATORYRESPONSE WAS FOUND FOLLOWING INTRACISTERNAL INOCULATION OF PURIFIED HIB CAPSULAR POLYSACCHARIDE (POLYRIBOSYLRIBITOL; PRP). IN CONTRAST TO PRP, THE …
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ENGINEERING PHAGE HOST RANGE PROMISCUITY
… Salmonella Typhi has been identified as the Vi capsular polysaccharide (CPS). This study aimed to develop a promiscuous phage receptor expression system allowing infection in a broad range of heterologous hosts. The S. Typhi Vi CPS biosynthetic operon was cloned into a broad host range cosmid …
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