Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"capillary network"”.
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Three-dimensional polymeric capillary network: fabrication and applications
Micro capillary networks widely exist in nature in forms of mass transport pathways, such as blood vessels. However their complicated geometry and the extra fine small features bring a great challenge to their potential applications in term of fabrication. To overcome the fabrication challenge, we …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… systems worldwide. The skeletal muscle capillary network has emerged as a critical determinant of metabolic homeostasis and structural remodelling of this network is now widely accepted to contribute to the pathogenesis of obesity. However, the regulation of skeletal muscle capillary …
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Pharmacokinetics of local growth factor delivery in myocardial tissue
… the convection of blood in the highly vascular capillary network. Attempts to find effective ways of delivering therapeutic macromolecules to myocardium that could maximize the impact of the agents and minimize systemic toxicity and adverse side effects have been hampered by the minimal …
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Development of an integrated microfluidic platform for oxygen sensing and delivery
… metal oxide film with a microfluidic capillary network to facilitate oxygen exchange with flowing blood and replicate pulmonary capillary respiration. This thesis focuses on the optimization of this microfluidic capillary network with respect to hemocompatibility, mass transfer, and …
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Mapping Anisotropic Tissue Fiber and Microvasculature Architecture With Diffusion MRI: Application to Skeletal Muscle and White Matter
… in order to extract information about the capillary network anisotropy. Third, in the study of the white matter fiber architecture, a diffusion acquisition technique combining multi-shot diffusion imaging with a reduced-FOV approach is developed in order to increase the spatial resolution …
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FLUID FILTRATION FROM CAPILLARY NETWORKS (MICROCIRCULATION, MATHEMATICAL MODELING).
… which describes the fluid exchange from a capillary network of realistic topology, and calculates the spatial distribution of extravascular pressure. In this model, the capillaries are represented by a superposition of sources and sinks, resulting from a D'Arcy's Law description of flow in …
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Ontogenesis of the cornea and ciliary body : a morphological and molecular study
… A striking similarity between the developing capillary network and the adult ciliary folds was observed and suggests that the patterning template for the ciliary processes could be the underlying capillary network. Cell proliferation measurements and cell height assessments indicated that one …
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Investigating the Impact of Environmental Stressors on Skeletal Muscle Angio-Adaptation
… (angiogenesis) or regression of the muscle capillary network. The influence of environmental stressors (hypoxia, cold-stress) on skeletal muscle angio-adaptive responses are less understood in comparison to exercise-training or diseased states. This thesis addresses the influence of hypoxia …
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Fabrication of microfluidic devices for artificial respiration
… scalable building block, we developed a noble "network" design which was structurally similar to the native pulmonary capillary network. The interconnected channel geometry was designed in such a way to minimize shear stress and reduce hemolysis and thrombosis inside the microchannel. It allowed …
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TRPV4 in the Choroid Plexus Epithelium: Pathway Analysis and Implications for Cerebrospinal Fluid Production
… of a high resistance epithelium surrounding a capillary network, the CP epithelium acts as a barrier, regulating ion transport between the CSF and blood. Transient Receptor Potential Vanilloid-4 (TRPV4) is a nonselective Ca2+-permeable cation channel expressed in the CP which is being …
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The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart
… been suggested that a failure of angiogenesis (capillary growth) to keep pace with myocyte expansion is the driving force which pushes hypertrophied hearts into a state of failure marked by contractile dysfunction and alterations in the mechanisms governing energy production. The aims of this …
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Investigating pulmonary vascular B cells
… is neutrophils which are found within the lung capillary network. Within the pulmonary capillaries, there is a population of neutrophils which remains adherent to the vascular endothelium for extended periods of time and exhibits marginated behaviour. While pulmonary vascular neutrophils are …
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Oxygen Transport in the Human Placenta: A Multi-Physics Modelling Approach
… with the study of blood flow through the fetal capillary network, with particular interest in its role on the oxygen transport capacity of the terminal villi. The computational models are corroborated by a particle image velocimetry (PIV) experiment. The study shows that the variation in …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… inhibits HDLEC proliferation, migration, and capillary network formation; these effects were coincident with increased levels of HEY1 and HEY2, biphasic regulation of VEGFR-3, and decreased levels of VEGFR-2. Using genetic intervention of Notch signaling, we demonstrated that Notch regulates …