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Showing 1 to 20 of 62 for “"capillary electrophoresis (CE)"”.
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Analysis of non-classical neurotransmitters using capillary electrophoresis
Capillary electrophoresis (CE) is a powerful tool for the analysis of complex microenvironments and has found widespread applicability to studies in neuroscience. Depending upon the selectivity and sensitivity requirements of the particular application, a variety of detection schemes for CE are …
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Development of radionuclide detectors for use in capillary electrophoresis
… of two radionuclide detection methods for capillary electrophoresis (CE) is described. The methods are used to determine the neuropeptide content of single neurons. The application of CE to single cell studies by several research groups is also reviewed with an emphasis on the variety of …
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Investigations of Chemiluminescence Detection Parameters for Kinetic Analysis and Capillary Separations
A post-column CL detection method for capillary electrophoresis (CE) was developed in which the capillary effluent was collected on a membrane which had been coated with bis(2,4,6-trichlorophenyl)oxalate, a CL reagent. After the CE run, the CL reaction was initiated on the membrane by applying …
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Novel Mass Spectrometric and Sampling Strategies for Investigating Neuropeptide Processing and Distribution
… to identify peptides, to determine new processing pathways, and to assess genetic variations. In some instances, however, alternative sampling approaches such as microseparation with MALDI MS detection are necessary to pre-concentrate and partially purify neuropeptides and to reduce …
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Formulation of electrophoretic module for integration onto silicon-on-insulator neural probes
Capillary electrophoresis (CE) has become a key analytical technique, especially in neurochemistry, due to its high separation efficiency and ability to analyze complex mixtures at a small scale [1]. However, challenges remain when it comes to scaling CE systems to match the demands of specific …
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Capillary electrophoresis of pteridines in urine and plants and quantification of pharmaceutical and personal care products in Missouri waste water
<p>"Capillary electrophoresis (CE) is a powerful technique that separates molecules based on their respective charge and hydrodynamic size. The major advantages of CE are high separation efficiency, small sample volume requirements, simple to no sample preparation and often organic solvents are not …
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Development and application of novel capillary electrophoresis techniques for analysis of DNA fragments and organic pollutants
Several capillary electrophoresis (CE) techniques had been developed to improve CE performance, pertaining to sensitivity, resolution and versatility. For analysis of DNA fragments, a potential gradient detection was designed and coupled with a portable CE system for DNA electrophoresis. In …
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Capillary Electrophoretic Technologies for Single Cell Metabolomics
… and neuromodulatory compounds. Single cell measurements aid in the discovery of neurotransmitters used by small subsets of neurons that would be diluted below detection limits or masked by ubiquitous compounds when working with larger brain regions. Also, as neurochemistry can be …
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On-chip multi-dimensional biomolecule separation using multi-layer microfabricated valves
Recent proteomics researches require a sensitive, high-speed, and automatic protein separation tool that far exceeds the capability of traditional two dimensional (2D) protein gel electrophoresis. Methods are described to achieve multi-dimensional biomolecule separation in a microfluidic channel. …
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Degenerate Oligonucleotide Primed - Polymerase Chain Reaction Evaluation And Optimization To Improve Downstream Forensic STR Analysis Of Low Quality/Low Quantity DNA
… STR analysis methods do not generate acceptable profiles. Whole genomeamplification can be used to pre-amplify the entire genome for downstream analyses. A commercially available kit for DOP-PCR, a form of WGA, is currently being used in the clinical for downstream single locus targets. …
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Synthesis & retention mechanisms of novel mixed mode stationary phase for detection of specific polar low molecular weight biological samples
… of Bisphenol A and related species using capillary electrophoresis (CE) coupled with boron-doped diamond electrodes for electrochemical detection. The synthesis and characterization of the novel mixed mode stationary phases prepared in this work is an important contribution to the field as …
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Core-based hyperbranched polyethyleneimine coating in capillary electrophoresis
In capillary electrophoresis (CE), chemical and dynamic modification of a fused silica surface can be used to control the electroosmotic flow (EOF), to minimize the interaction of analytes with the capillary surface and to modify the selectivity. , core-based hyperbranched polyethyleneimine (CHPEI) …
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CE-LIF ANALYSIS OF INTACT MARINE MICROBES ALONG WITH THEIR CONSTITUENT PHYCOBILIPROTEINS AND PHYCOBILIN PIGMENTS
… to the marine biosphere as primary producers and as participants in global carbon and nitrogen cycles, and so it is vital to develop efficient methods for cyanobacteria quantitation and characterization. Capillary electrophoresis (CE) methods with dual-wavelength laser induced …
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Membrane-Based Protein Preconcentration Microfluidic Devices
Interest in microchip capillary electrophoresis (CE) is growing due to the rapid analysis times provided and small sample input requirements. However, higher-concentration samples are typically needed because of the small (~pL) detection volumes in these devices. I have made membrane-based protein …
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Investigations of Serotonin Metabolism in Mammalian and Other Deuterostome Model Systems
… Xenoturbella bocki, a marine worm, and Strongylocentrotus purppuratus, the sea urchin as well as mammals such as Rattus norvegicus. Studies were performed using a highly specialized capillary electrophoresis (CE) system designed to detect 5-HT and related compounds at attomole levels. The …
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Optical Characterization of Ultrasmall, Hydrogen-Terminated and Carboxyl-Functionalized Silicon Nanoparticles in Aqueous Environments
… focusing on their potential for use as luminescent markers in biophysical and biological applications. Two systems are presented in detail: (1) Chapters 2-4 cover hydrogen-terminated Si-np that are prepared through electrochemical dispersion of a crystalline Si wafer and (2) Chapters 5-6 …
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METHOD DEVELOPMENT FOR THE ANALYSIS OF PROTEINS AND SMALL
… small molecules important in environmental science, food science, pharmaceutical, and medical matrices. Many of these separations utilize instrumental methods such as capillary electrophoresis (CE) and high performance liquid chromatography (HPLC) to alleviate the complexity of these various …
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In vitro selection of aptamers using quantum dot-assisted capillary electrophoresis SELEX
… are short, synthetic oligonucleotide sequences that can selectively bind to targets with high affinity. Selection of aptamers is accomplished by the Systematic Evolution of Ligands by EXponential enrichment (SELEX). The target is incubated with a random sequence oligonucleotide library, and …
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Further investigation of capillary electrophoresis for pharmaceutical analysis
… current analytical methodologies used for pharmaceutical analysis, their advantages and disadvantages. In this context the potential of capillary electrophoresis (CE) is established through a study of the current literature. Capillary electrophoresis method is developed and optimised for …
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