Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"canonical translation initiation"”.
-
Human non-canonical translation initiation factors EIF4E2 and EIF4E3
The family of eukaryotic translation initiation factors 4E (EIF4E) comprises of a group of proteins that recognise the 7-methylguanosine cap at the 5' mRNA end to initiate translation. In humans, there are three isoforms, EIF4E1, EIF4E2 and EIF4E3. EIF4E1 participates in global translation and is …
-
Elucidating the role of eukaryotic initiation factor 5B (eIF5B) in non-canonical translation initiation
Cap-dependent translation drives the global synthesis of proteins. Under stress conditions global protein production is attenuated, yet the translation of ATF4 is upregulated through uORF- mediated translation initiation. eIF5B has been shown to deliver initiator-tRNA during non-canonical …
-
Analysis of the Role of EIF5A in Mammalian Translation
… Analysis of screening data identified eukaryotic initiation factor 5A (EIF5A) as novel regulator of MYC translation. eIF5A is a highly conserved translation factor that has been demonstrated to relieve ribosome pauses during translation elongation at 'difficult to translate' peptide sequences in …
-
CHARACTERIZATION OF THE EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (eIF4E) FAMILY MEMBERS IN THE ZEBRAFISH (Danio rerio)
… in zebrafish. In addition to the prototypical translation initiation factor eIF4E, eukaryotes have evolved eIF4E variants with distinct characteristics, some of which negatively regulate the recruitment of specific mRNAs. Metazoan eIF4E family members fall into three classes, with Class I …