Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"canonical base"”.
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Synthesis and Spectroscopic Studies of Substituted Pyrrolocytidines
… in nucleic acid chemistry. These heterocyclic base surrogates that are capable of canonical base pairing have use in the study of nucleic acid conformation, as reporters of the state of hybridization.[1] The synthesis of a 5-phenylpyrrolocytidine was attempted in order to compare its properties …
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Aminormotiffinder - a graph grammar based tool to effectively search a minor motifs in 3D RNA molecules
… structure variations. Here a "graph rewriting" based method is proposed to identify motifs in real three dimensional structures. The unique encoding of A Minor Searcher takes into consideration the non canonical base pairs and also multipairing of RNA structural motifs. The accuracy is …
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CRISPR gene editing for Cystic Fibrosis: targeting the G542X mutation with base editor engineered virus-like particles
… care and face a reduced life expectancy. CRISPR-based gene editing offers the potential for a cure, by addressing the underlying cause of the disease. The doctoral work presented in this dissertation explored the avenue of CRISPR therapeutic gene editing for CF, while also testing and …
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Explanation of independence
… of indiscernibles and studying its relation to canonical bases.
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Designing 3D Wireframe DNA Nanoparticles for Programmable Innate Immune Activation
… harnesses the predictability and specificity of canonical base pairing interactions to enable the synthesis of complex DNA nanodevices capable of interacting with their environment in a controllable manner. Wireframe DNA origami are a class of highly customizable DNA nanoparticles that can be …