Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"cannabinoids"”.
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Medicinal Chemistry of Cannabis and Cannabinoids
… cannabis as well as the pharmacodynamics of cannabinoids and cannabis extracts. As such, deconvoluting the chemical complexity of cannabis is essential for maximizing its therapeutic benefits and reducing adverse effects in the clinic. Accordingly, this thesis presents a comprehensive …
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Cannabinoids and Psychosis – Cause and Treatment
<p>Epidemiological studies suggest that cannabis is a risk factor for psychotic illness. The main active ingredient is Δ-9-Tetrahydrocannabinol (THC). In healthy humans, the acute administration of THC can elicit transient psychotic symptoms and cognitive impairment. THC stimulates the …
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Non-Psychotropic cannabinoids attenuate visceral pain in colitis
… (THC). These non-psychotropic cannabinoids (npCBs) have a variety of effects including analgesia and anti-inflammatory actions and show potentiating effects when administered in combination. This project explored the analgesic effects of cannabichromene (CBC), cannabidiol (CBD), …
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Cannabinoids: A Novel Treatment Strategy for Retinal Neurodegenerative Disorders
<p>Synthetic and naturally occurring cannabinoids are known to decrease intraocular pressure (IOP). Glaucomatous damage to the retina and optic nerve progresses even after therapy to maintain normal intraocular pressure (IOP). Topical application of cannabinoids decreases IOP while not affecting …
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Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… results in impairments of skilled behaviour. Endocannabinoids have been shown to affect spinal locomotion and stress has been shown to affect spontaneous locomotion therefore, the effect of cannabinoid signaling and stress on motor map expression and behaviour was examined. The first study …
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Single and Combined Effects of Cannabinoids on Neuropathic Pain and Cognition
… The cannabis plant contains various other cannabinoids besides -9-THC. Most of the effects of cannabinoid-based therapies are based on the agonistic action of -9-THC through cannabinoid receptors. Alternatively, some of these effects are caused by the actions of other cannabinoids, like …
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Impacts of breeding and cultivation practices on cannabinoids in industrial hemp
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Modulation of the sensitivity of nociceptive neurones by cannabinoids and SNSR
… development of analgesics. The receptors for cannabinoids, the active ingredients of cannabis, have been found in some primary sensory neurones. Given the known ability of these receptors to inhibit adenylate cyclase, the activation of which leads to the sensitisation of nociceptors, calcium …
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Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
Cannabinoids produce antinociception in many preclinical models of acute and chronic pain. In contrast, cannabinoids produce inconsistent analgesia in humans, showing little or no efficacy in treating acute pain, with modest efficacy in treating chronic inflammatory pain. This discrepancy may …
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The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… including matrix metalloproteinases (MMPs). Cannabinoids have been shown to reduce joint damage in animal models of arthritis and have also been shown to prevent IL-1 induced matrix breakdown of collagens and proteoglycans, suggesting a chondroprotective effect of these compounds. …
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Diagnostic use of hair analysis for the detection of misuse of amfetamines and cannabinoids
… and retention times for amfetamines and cannabinoids were identified by GC-MS using derivatization agents, PFPA/ethyl acetate (2:1 v/v) and PFPA / PFPOH (1:0.75 v/v) for amphetamines and cannabinoids, respectively. The results showed good peak shape, good chromatographic resolution and …
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Modulation of the vascular function by cannabinoids, calcitonin gene related peptide and connexin hemichannels
… promoting vasodilation or vasoconstriction. Cannabinoids have been used for centuries for their psychoactive properties, but they have also a profound influence on the cardiovascular system, leading to vasodilation. Vasorelaxation by cannabinoids can be mediated by stimulation of cannabinoid …
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Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
… deriving from polyketide synthases are the cannabinoids. Having a long history of use, yet controversial nature Cannabis offers the possibility for the treatment of many diseases. Reports are varied, however, possibly due to the affect of numerous and under-studied minor cannabinoids. A …
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Comparing Extraction Methods in Sample Preparation for the Quantification of Cannabinoids in Industrial Hemp
… for sample preparation or quantification of cannabinoids (including THC) in Cannabis. Extraction efficiency of phytochemicals is well-known to depend on the solvent and extraction method used. In this project, we evaluated the effect of sample preparation extraction methods on the …
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Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids
The mechanisms underlying cannabinoid impairment of fear memory is not clear. This study investigated the effects of the synthetic cannabinoid HU210 and the endocannabinoid hydrolysis inhibitor JZL 195 on fear memory following contextual fear conditioning (CFC; an animal model of fear). The …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
… diseases. Numerous reports suggest that cannabinoids, known to exhibit general immunosuppressive properties, have potential therapeutic value in the treatment of inflammatory conditions. In relation to multiple sclerosis (M.S.), cannabinoids palliate M.S. patient symptoms and the severity …
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From macromolecular crowding to transcriptional regulation: Exploring the complexities of cytochrome P450s, cannabinoids, and inflammation
… that eicosanoids also function as endocannabinoids has opened the door to comparisons with phytocannabinoids and questions about how the presence This work is aimed at untangling the complex web of P450 interactions with the environment and cannabinoids, the regulation of inflammation, …
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Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models of Pain: Is Less More?
… system, by looking at whether opioids and cannabinoids interact at the ultra-low dose level, whether cannabinoid receptors themselves demonstrate the ultra-low dose antagonist effect, and whether the opioid ultra-low dose effect is maintained in a model of persistent, unavoidable pain. For …
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A toxicological survey of acute psychoses in Cape Coloured males with special reference to the cannabinoids
… technique was used for the detection of urinary cannabinoids. To exclude the contribution of other psychotropic agents to the aetiology of the psychoses, gas chromatography was performed to detect ethanol and thin-layer chromatography to screen for other psychotropic agents. ii. To assess the …
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Ghrelin, Cannabinoids, and Motivation: Increased Food Motivation on Progressive Ratio Paradigm Through MAGL/FAAH Inhibition in a Rat Model
Both ghrelin and endogenous cannabinoids act in the ventral tegmental area (VTA) to increase feeding behaviours, through their interaction is not understood. It is hypothesized that ghrelin influences this system by stimulating the release of endocannabinoids from dopamine cells through its …
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