Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"cannabinoid receptor 2"”.
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… studies have reported that administration of cannabinoid receptor agonists in inflammatory/autoimmune and CNS injury models resulted in significant attenuation of clinical disease. The beneficial effects correlated with the observed reduction of inflammatory mediators and peripheral immune …
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Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs)
… can benefit from the pharmacological effects of cannabinoids. Plethora of evidence is available for the use of cannabinoids for the anti-inflammatory and immune modulating activity. The targets for therapeutic intervention include the cannabinoid type 1 and 2 receptors (CB1R and CB2R). The CB2 …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… disease. Recently, it has become evident that cannabinoids have immunosuppressive properties and can be used as therapeutics for various inflammatory diseases. The main aim of this study was to explore the anti-inflammatory effects of CB2 agonists on allergic airway inflammation using a mouse …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… disease. Recently, it has become evident that cannabinoids have immunosuppressive properties and can be used as therapeutics for various inflammatory diseases. The main aim of this study was to explore the anti-inflammatory effects of CB2 agonists on allergic airway inflammation using a mouse …
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Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
… Cannabis sativa with approximately 100 being cannabinoids. Of those 100 compounds, Δ9-THC has been determined as the primary constituent, which is also responsible for the psychoactivity associated with Cannabis. Along with Δ9-THC, cannabidiol has been studied in depth for its therapeutic …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate glucose and lipid metabolism, inflammation and energy storage. Specifically, diabetes mellitus and obesity induces alterations in the expression of cannabinoid …
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Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands
The endocannabinoid system is a complex homeostatic signaling system controlled through the actions of two g-protein coupled receptors, cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2). Significant neuronal expression and distribution of cb1 throughout the brain establishes its …
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Lipid Signaling Under Microgravity Conditions
… by endogenous bioactive lipids such as endocannabinoids, sphingolipids, eicosanoids, and specialized pro-resolving mediators (SPMs). Each signal plays a role in different phases of the inflammatory response. Notably, our research group has previously demonstrated that both real and simulated …
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MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
… were resistant to N-methyl-D-aspartate (NMDA) receptor-mediated toxicity. Using microelectrode arrays and RNA-seq, we recorded altered spontaneous neuronal activity and co-occurring changes in gene expression that both validated established pathways and identified novel targets for future …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… Dietary EPA and DHA are converted to omega-3 endocannabinoids (eCBs), eicosapentaenoicethanolamide (EPEA) and docosahexaenoicethanolamide (DHEA), respectively. Subsequently, omega-3 eCBs are substrates for eicosanoid-synthesizing enzymes, cyclooxygenase, lipoxygenase and cytochrome P450 (CYP450) …
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Development and Characterization of Selective CB2R Inverse Agonists as a Novel Anti-Inflammatory Therapy for Neuroinflammation – Mechanisms of Action in Murine and Human Microglia Models Provide Valuable Insights into Their Therapeutic Potential
… Recently, research has revealed the presence of cannabinoid receptor 2 (CB2R) in the central nervous system (CNS); since then, the receptor has emerged as a promising therapeutic target for treating multiple neurodegenerative diseases (NDD) such as Alzheimer’s (AD), Parkinson’s (PD), Human …
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
… mediated oxygenation of omega-6 derived endocannabinoids, thereby revealing a previously unknown metabolic pathway. The endocannabinoids, anandamide (AEA) and 2-arachidonylglycerol (2-AG), are endogenous lipid mediators that are agonists of cannabinoid receptor-1 (CB1) and cannabinoid …