Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cannabinoid CB1 receptor"”.
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Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Human and Rat Spinal Cord Tissue
… evidence suggests that cannabis, a potent cannabinoid, has potential analgesic properties. However, there is a gap in the literature in respect to cannabinoid receptor expression and localization in the spinal cord across both sex and species, with almost nothing known in humans. We used …
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Characterization and development of a stroke-induced model of acquired epilepsy in organotypic hippocampal slice cultures: role of the cannabinoid CB1 receptors in modulation of neuronal excitation and inhibition
… studies point to a modulatory role of the endocannabinoid system in controlling seizures. Animal models of stroke induced acquired epilepsy have been difficult to develop. Therefore, this dissertation was initiated to develop an organotypic hippocampal slice culture model of acquired epilepsy …
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Il Δ9-THC, componente principale della cannabis sativa, attenua la neurotossicità indotta dalla meth
… (Δ9-tetrahydrocannabinol, Δ9-THC) and synthetic cannabinoid CB1 receptor agonists exert neuroprotective effects in different models of cerebral damage, including excitotoxic injury [Deng X and Cadet JL, 2009; La Voie MJ, et al. 2004]. In this study we evaluated the neuroprotective effect of …
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Distribution and function of TRP ion channels in primary sensory neurons
It is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve …
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Possibile ruolo del sistema endocannabinoide nel disturbo d’alimentazione incontrollata (binge eating disorder): studi comportamentali, farmacologici e biochimici
… of evidence supports a contribution of the endocannabinoid system in the modulation of energy balance by controlling food intake through central and peripheral mechanisms. The cannabinoid CB1 receptor is abundantly expressed in the central nervous system and induces inhibition of …
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Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation
… to increase the production and release of endocannabinoid molecules. Additionally, endocannabinoids are potent regulators of appetite, energy balance and metabolic processes through both central and peripheral regulation of feeding and metabolism, making the system an ideal candidate. Mice …
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Characterization of Rimonabant effects on G protein activity
G protein-coupled receptor (GPCRs) is the largest class of cell-surface receptors, and represents today the target of 40% of the drugs in the pharmaceutical market. In the absence of agonists, many GPCRs have found to exhibit spontaneous activity, which can be blocked by ligands that are referred …
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Effetto nell’auto-somministrazione dell’agonista sintetico del recettore cannabinoide CB1, WIN 55,212-2, nel modello animale di depressione della bulbectomia olfattoria (OBX)
… rats display higher voluntary intake of the cannabinoid CB1 receptor agonist WIN 55,212-2 (WIN, 12.5 μg/kg/infusion). The olfactory-bulbectomized rat is a well-established model that exhibits a high degree of behavioural and neurochemical similarity to depression. Male Lister Hooded rats were …
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… therapeutic roles of Histaminergic H3 and Cannabinoid CB1 receptors in neurodegenerative diseases. Based on neurochemical investigations in postmortem human brain samples, the status of H3 receptors remain unchanged under vascular dementia or mixed dementia pathology, and may serve as a …
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Pharmacological modulation of learning and memory in mice and zebrafish: Implications for Alzheimer’s disease animal models
… to be used for cognitive enhancement is CB1 cannabinoid receptor antagonist. CB1 cannabinoid receptor antagonists have been shown to improve learning and memory in rodents, whereas CB1 cannabinoid receptor agonists have been shown to impair memory. The project has overall aims of (1) …
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The endocannabinoid system in critical neurodevelopmental periods: Focus on its role in the pathophysiology of schizophrenia as neurodevelopmental disorder [Il sistema endocannabinoide nei periodi critici del neurosviluppo: Focus sul suo ruolo nella fisiopatologia della schizofrenia come disturbo dello neurosviluppo]
… a sostegno del coinvolgimento del sistema endocannabinoide nella fisiopatologia della SCZ, questa tesi si è posta l’obiettivo di studiare il ruolo del sistema endocannabinoide (EC) nello sviluppo cerebrale e il potenziale terapeutico della modulazione farmacologica precoce del sistema …