Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"canine osteosarcoma"”.
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The role of autophagy in canine osteosarcoma
Canine osteosarcoma (OS) is a primary tumour in the bone and is mesenchymal in origin. The common sites affected are the metaphyseal regions of long bones, particularly the front limbs of dogs. Osteosarcoma in dogs shares many biological and clinical resemblances in humans with molecular and …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
Osteosarcoma (OS) is the most common bone cancer in dogs. It is biologically aggressive and <20% survive >2 years with standard therapy. Hence, new approaches must be considered. TP53 is altered in ~50% of human and canine cancers, including OS, making it a candidate for targeted suicide gene …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
Canine osteosarcoma (OS) is a malignant neoplasia of the osteoblast, most often identified in the appendicular skeleton, which is both locally aggressive and highly metastatic. The standard of care treatment of amputation and adjuvant chemotherapy yields a median survival time of 10-12 months, an …
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Investigating procaspase-3 as a potential therapeutic target in canine osteosarcoma
… activating compound, in the treatment of canine osteosarcoma. Procaspase-3 is expressed in osteosarcoma cells, and furthermore, greater expression is seen in malignant canine osteoblasts than normal osteoblasts. Exposing cells to PAC-1 results in the activation of procaspase-3 to …
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Isolation and characterisation of canine osteosarcoma cells to investigate mechanisms of chemoresistance
Background: Osteosarcoma (OSA) is the most prevalent primary bone cancer in humans and is 27 times more prevalent in dogs. Unfortunately, over the past 2 decades, the rate of 5-year survival for metastatic OSA has not improved in humans or dogs. It is thought that this is mainly due to …
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Analysis of DNA methylation in canine osteosarcoma using next generation sequencing technology
Osteosarcoma is the most common type of malignant bone cancer found in dogs (Canis familiaris), with in excess of 25,000 cases diagnosed annually. DNA methylation is a form of epigenetic modification that is essential for normal development and gene transcription regulation; however, aberrant DNA …
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Understanding the role of interleukin-8 (IL-8) in canine osteosarcoma metastasis
The student, Matthew Dowling, accepted the attached license on 2018-06-20 at 22:06.
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In vitro anti-cancer effects of benzimidazoles on the canine osteosarcoma D17 cell line
The high morbidity and mortality of canine osteosarcoma (OS) despite standard therapy warrants the need to investigate new treatment options. One avenue in exploring novel therapies is drug repurposing – using drugs with known dosing, toxicity profiles, and pharmacokinetics, and re-purposing them …
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Developing canine osteosarcoma and human non-small cell lung cancer PDX models to study immunotherapies targeting canine and human T cells
… to further test our Fabs specific for human or canine T cells and establishes the potential benefit of using them to treat cancer in these species. The final goal of developing these models is to determine the potential of using T cell targeting Fabs to increase efficacy but not the toxicity of …
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Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… receptor agonists as an immunotherapeutic for canine osteosarcoma. From a comparative and translational perspective, the long-term goals of this research include not only the treatment of canine osteosarcoma, but also human osteosarcoma, as this disease has numerous similarities between …
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Preclinical Models to Identify Molecular Drivers of Metastasis in Paediatric Musculoskeletal Cancer
… (MS) cancers such as Ewing’s sarcoma and osteosarcoma account for 5% of childhood malignancies in the UK. Despite advances in surgical intervention and chemotherapy, the survival of patients with these malignancies has not improved substantially over the last 20 years. Current knowledge of …
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Mesenchymal stem cell rescue for bone formation following stereotactic radiotherapy of osteosarcoma
Background: Osteosarcoma (OSA) is the most common form of primary bone cancer in dogs and humans. Curative-intent treatment options include amputation, radiation therapy or surgical limb salvage for local tumor control combined with adjuvant chemotherapy for prevention or delay of metastatic …
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Investigating couplet strategies incorporating 4 pillars of cancer therapy
… chemotherapeutic, doxorubicin, for managing canine pulmonary metastatic osteosarcoma. We have also sought to rationalize the exploration of PAC-1 with radiotherapy in Chapter IV. The effect of PAC-1 on proteins involved in DNA damage response and repair are investigated and procaspase-3 …
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Development of a canine model to evaluate CAR-T cell subsets
… first aim of this dissertation was to develop a canine CAR-T model for functional assessments of canine CAR-T cells. The second aim of this dissertation was to explore cell subsets using single cell sequencing. We first sought to establish a canine CAR-T cell in vitro model system. We …