Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"canine model"”.
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Development of a canine model to evaluate CAR-T cell subsets
… largely been resolved using in vitro and mouse models, where methods to overcome resistance have also been developed. While our mechanistic understanding of tumor and immune biology has been propelled to a place where beneficial therapies are being employed, there is a need for more clinically …
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Biomechanical and histological evaluation of a new zirconia implant in a canine model
… and acid-etched surface treatment in a canine model. Material and Methods: Six beagle dogs (1-2 years old) will be used in this split mouth trial. After 8 weeks following extraction of the second to fourth mandibular premolars, zirconia implants (experimental group) and titanium implants …
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Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics
… are currently being examined. A knock-out mouse model and several naturally occurring animal models of MPS IIIB have been reported. To date, the mouse and canine models of MPS IIIB have been utilized for pathogenesis and therapeutic studies. The canine model is an ideal animal model because their …
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The effects of gene replacement therapy on respiratory and gait function in a canine model of X-linked myotubular myopathy
… mediates MTM1 replacement. A naturally-occuring canine model of the disease displays a phenotype similar to that seen in patients, including markedly reduced survival, and decreased strength and function in the muscles of the limbs and respiratory system. XLMTM dogs were treated once with AAV8 …
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Phosphorylation of TASK-1 and its role in atrial arrhythmias
… and the development or maintenance of various models of atrial fibrillation. Signaling downstream of PAF was previously shown to inhibit the two pore-domain potassium channel TASK-1. This inhibition required the activity of the epsilon isoform of protein kinase C, and a putative phosphorylation …
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Therapeutic potential of the anti-fibrotic drug Suberanilohydroxamic acid (SAHA) in canine corneal fibrosis
… mediating the antifibrotic effect of SAHA in the canine cornea using an in vitro model and (2) to develop a novel in vivo model of corneal fibrosis in dogs utilizing alkali burn and assess the ability of SAHA to inhibit fibrosis using this canine model. Methods: In study 1, canine corneal …
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Muscle Metaboreflex And Arterial Baroreflex: Action, Interaction And Altered Control In Heart Failure
… failure animals. Using chronically instrumented canine model, data was collected before and after the induction of heart failure. We found that: 1) muscle metaboreflex activation induces epinephrine release causing β2-mediated vasodilation in skeletal muscle, 2) muscle metaboreflex activation …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… the potential of Akt-targeted therapy in a canine model of histiocytic sarcoma. We demonstrated Akt signaling to be active in 9 out of 10 canine HS tumor samples, regardless the presence of PTEN. Moreover, the Akt signaling pathway appears to be constitutively active in DH82 cells — a cell …
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New Paradigm of Defibrillation: Towards Painless Therapy
… optical mapping techniques and several animal models of ventricular and atrial arrhythmias, we develop and validate several novel low-voltage defibrillation therapies for atrial and ventricular arrhythmias. Several important previous studies on mechanisms of arrhythmia maintenance and …
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Do Canines Experience the Effects of Heart Rate Turbulence?
<p><b>Background</b></p> <p>The canine cardiac system has been the model against which many Class III cardiac devices are validated. Thus, it is expected that the canine heart has very similar electrical model to that found in humans. In 1999, the absence of Heart Rate Turbulence (HRT) after a …
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Muscle Metaboreflex Control Of Cardiovascular Function In Hypertension
… failure. Employing a chronically-instrumented canine model, data were collected from control animals and the same animal after induction of HTN. We addressed three specific questions: 1) what are the mechanism(s) mediating the muscle-metaboreflex-induced pressor response observed during PEMI in …
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Improving Nk Cell Therapy For Osteosarcoma
… OS <em>in vitro</em> and in murine models. However, there is little data regarding their efficacy in animal models with an intact immune system. In addition, the OS tumor microenvironment is highly suppressive, producing TGFβ which impedes NK cell killing of solid tumors. We set out …
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Mapping the Characteristics of Atrial Activation Patterns During Atrial Fibrillation
… multisite mapping (512 recording sites) in the canine sterile pericarditis model and in AF patients. Studies of AF in the canine sterile pericarditis model have demonstrated that AF is due to one or more driver sites firing rapidly causing fibrillatory conduction. The ability to reliably …
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Reactions of Nitroxyl and Nitrite in Blood
… (3) AS alone, and (4) saline (control) in a canine model. The infusion of Hb alone led to significant increases in blood pressure and symptoms of circulatory distress, as was expected, and infusion of AS alone led to significant decreases in these parameters. Co-infusion of AS with Hb had an …
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The Effect of Preload Reduction on Parameters to Evaluate Left Ventricular Diastolic Function
… a preload independent parameter in experimental canine model. The impact of preload on this index, however, has not been studied in human. The purpose of this study was to evaluate the effect of the hemodialysis related preload reduction on conventional and new Doppler indices of LV diastolic …
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The biomechanical properties of the human vocal fold.
… to assist with the derivation of mathematical models of phonation; and to provide methods to assess objectively the effectiveness of tissue engineering therapies used to repair scarred vocal folds. The author devised a new and novel apparatus to obtain data from excised tissue and in vivo. A …
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
… Our initial experiments were conducted in a rat model of ex vivo perfusion preservation. Hearts were perfused with cold, oxygenated organ preservation solution (University of Wisconsin Machine Perfusion Solution) supplemented with carefully-selected candidate carbon-13 (13C) labeled myocardial …
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From genomics to function: Canine genetics highlight novel mechanisms of obesity and related traits
… prevalent complex disease with burdens on both canine and human health. It is a multifactorial disease with many environmental and biological risk factors and is highly heritable in humans, pointing towards a role for genetics. Obesity heritability is also observed in dogs where breeds show …