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Showing 1 to 9 of 9 for “"canine lymphoma"”.
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Flow cytometry in the diagnosis and prognosis of canine lymphoma and leukemia
Chapter one explores new markers of prognosis for canine lymphoma by using flow cytometry of lymph node aspirates. Data from one hundred and sixty dogs with confirmed multicentric B-cell lymphoma were used to test the hypothesis that poor patient outcome could be predicted by tumor cells expressing …
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Immune Checkpoint Molecule Expression in Canine Lymphoma and Canine Reactive Lymphoid Hyperplasia
Background: Although lymphoma is one of the most common malignancies in dogs, remission rates and survival times remain stagnant. Treatment with a multi-agent chemotherapy protocol induces remission for less than one year and the majority of patients relapse. Fewer than 25% of dogs live longer than …
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Metabolism of lomustine in dogs and comparative cytotoxicity of lomustine and its major metabolites and O6-methylguanine-DNA methyltransferase expression in canine cells
… of malignancies, most commonly brain tumors and lymphoma. Lomustine undergoes hydrolysis in vivo to form isomeric metabolites, primarily trans-4-hydroxylomustine (trans-4) and cis-4- hydroxylomustine (cis-4) in various animal species including humans. Despite its widespread usage to treat canine …
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INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS
… role of programmed death-ligand 1 (PD-L1) in canine lymphoma, (2) the expression and prognostic role of CD47 in canine leukemias, and (3) the characterization of lymphocyte populations in peripheral blood and sentinel lymph nodes (SLNs) of dogs with mast cell tumors (MCTs). Regarding PD-L1, …
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Single cancer cell detection with optofluidic intracavity spectroscopy
… red and white human blood cells, as well as canine lymphoma and lymphocytes based on their distinctive transmission spectra. Using OFIS chips fabricated with the modified process, OFIS spectra of settled cells from canine hemangiosarcoma (HSA) cell lines and monocytes in peripheral blood …
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Molecular diagnosis of cancer using ambient ionization mass spectrometry
… subtyping using fine needle aspirations (FNA) of canine lymphoma specimens. Lipid profiles obtained from FNA samples were tested against a MS library built from a matched set of surgical tissue sections with disease states confirmed by histopathology. DESI-MS imaging was also used to expand upon …
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Effects of survivin and survivin inhibition in canine models of lymphoma and osteosarcoma
Canine lymphoma (LSA) and osteosarcoma (OS) have high mortality rates and remain in need of more effective therapeutic approaches. Survivin, an IAP (inhibitor of apoptosis) family member protein that inhibits apoptosis and drives cell proliferation, is commonly elevated in human and canine cancer. …
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… (HSA), and disseminated mastocytosis (MCT). Lymphoma is one of the most common cancer types affecting dogs and humans, and therefore, novel therapeutic approaches are always needed. For all of these cancer types, dogs and human cancers share common molecular abnormalities, consistent with a …
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Detection of Cell-free Tumor DNA in Liquid Biopsies of Dogs with B cell Lymphoma: A Biomarker Discovery
Lymphoma is a common hematopoietic malignancy in canines. Current diagnostic techniques to diagnose lymphoma are often invasive and expensive. Additionally, tumor heterogeneity complicates the accurate classification and diagnosis of specific subtypes, hindering the development of targeted therapy …