Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"cangrelor"”.
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Downstream Cangrelor versus upstream ticagrelor in patients with St-Segment elevation myocardial infarction
… l’assorbimento orale può essere ostacolato, il cangrelor per via endovenosa rappresenta un’alternativa. L’obiettivo di questo studio è stato confrontare il cangrelor somministrato dopo l’angiografia coronarica (ovvero, “downstream”) con il pretrattamento con ticagrelor (ovvero, “upstream”). …
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Investigating small-molecule inhibitors of platelet aggregation
… to further understand the mechanism of action of cangrelor – the most recently approved, and only intravenously acting P2Y12 antagonist; and 2) to discover novel, competitively acting, non-nucleotide-based reversible inhibitor(s) of ADP-induced platelet aggregation. A plate-based aggregometry …
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The Molecular Mechanism of Platelet Activation in Inflammation
… heparin, heparan sulfate (HS), aspirin, and cangrelor. Heparin and HS effectively neutralised histone activity in a dose-dependent manner, with heparin demonstrating nearly complete inhibition at 12.5 U/ml, while HS at 100 µg/ml entirely suppressed activation. Additionally, the antiplatelet …
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Development and experimental validation of a novel arterial thrombosis-on-a-chip microfluidic device
… events. To assess this approach, I tested cangrelor and aspirin using my device. I found the treatment to be effective when collagen alone was used as a trigger for thrombosis, but when tissue factor was also used, as would occur in vivo, treatment with cangrelor and aspirin was …
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A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
… results in a phase I clinical trial showed that cangrelor is an excellent candidate for preventing shunt thrombosis in neonatal patients after surgical operations. Using microfluidic devices, we demonstrated that thrombosis-and-hemostasis-on-a-chip could help us understand the mechanisms of …