Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"cancer-associated fibroblasts"”.
-
The Role of Cancer-Associated Fibroblasts In Lung Tumorigenesis
… of the microRNA-200 (miR-200) family. Cancer-associated fibroblasts (CAF) enhance tumorgrowth and invasion by secreting VEGF-A that binds to VEGFR1, a processrequired for tumor growth and metastasis in mice and correlated with a poorprognosis in lung adenocarcinoma patients. In this …
-
The Biomechanical Role of Cancer-Associated Fibroblasts In Tumor-Stroma Reciprocity
… to tumorigenesis will also be discussed. The cancer-associated fibroblast and the tumor-associated macrophage intimately influence the homeostasis between the tumor and extracellular matrix and can affect the survival and proliferation of tumor cells. This review will address how mechanical …
-
Crosstalk between natural killer cells and cancer associated fibroblasts in the tumour microenvironment
Cancer is a deadly disease where malignant cells proliferate and avoid elimination by the immune system. Although natural killer (NK) cells, of the innate immune response, recognise and eliminate cancer cells, their cytotoxic function is often impaired in the tumour microenvironment. Indeed, …
-
Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
The immune response to cancer is dependent on functionally efficient cytotoxic T lymphocytes (CTL). Checkpoint inhibition therapy is aimed at reinvigorating local cytotoxic T cells, however the rate of immunotherapy failure in non-small cell lung cancer (NSCLC) is as high as 80%. An improved …
-
Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… (PDAC) remains one of the deadliest cancers, with limited treatment options and poor survival rates. It is characterised by strong driver mutations, extensive epigenetic reprogramming, and a dense tumour microenvironment (TME). A defining feature of the PDAC TME is its fibrotic …
-
The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
Breast cancer is the most common cancer diagnosed in women in the United States. The basal-like breast cancer subtype represents about 12% of breast cancer and has the worst outcome in patients due to lack of effective therapies. Tumor stroma plays an important role in cancer progression. Cancer …
-
Regulation and inhibition of pro-tumorigenic microenvironments
… number one risk factor for the development of cancer. While accumulation of epithelial cell mutations is a driving factor for this risk, the role that the tumor microenvironment plays in this process is now well established. Indeed, seminal work has shown that tumorigenic cells unable to grow …
-
ELUCIDATING THE FUNCTIONS OF TAp73 IN BREAST CANCER
… isoform was highly expressed in human breast cancer as compared to the normal tissue. Therefore, this project aims to elucidate TAp73 functions in breast cancer development. Using three cell type-specific TAp73 knockout MMTV-PyMT mouse breast carcinoma mouse model, our results suggested that …
-
Single cell and spatial analysis characterize metabolic DPEP1+ fibroblasts in PDAC
… of novel therapeutic approaches. Understanding cancer-associated fibroblasts (CAF) metabolism reprogramming in PDAC tumor microenvironment (TME) may uncover novel therapeutic targets. Here, we used single cell and spatial transcriptomics to comprehensively characterize the TME content of human …
-
Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
<p>Colorectal cancer Colorectal Cancer (CRC) is the leading cause of cancer-related deaths, with the majority of these deaths occurring after metastases. In this study, we used single-cell RNA transcriptome sequencing to characterize the cellular and molecular features of primary CRC and colorectal …
-
Fibroblast Heterogeneity In Pancreatic Cancer Immunity
<p>Fibroblasts are a unique cell type defined by their mesenchymal phenotype and exclusion from epithelial, immune, and endothelial cell subsets. Although well studied in wound healing, cancer associated fibroblasts (CAFs) are incredibly heterogeneous, leading to contradictions as to the roles CAFs …
-
Use of fourier transform- infrared spectroscopic imaging as a tool for understanding early molecular events driving breast cancer progression
… breast tumor is a well-documented phenomenon. Fibroblasts are the cell type responsible for maintaining the stroma, and cancer-associated fibroblasts, characterized by the expression of α-smooth muscle actin (α-SMA) protein, are highly contractile compared with those found in normal tissue. …
-
Computational analysis of cell-cell communication in the tumor microenvironment
… we modeled metastatic triple negative breast cancer in the liver using a microphysiological system and identified inflammatory cytokines secreted by the microenvironment that result in the proliferation of dormant metastases. In the second study, we used single-cell RNA sequencing (scRNA-seq) …
-
The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
<p>Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer death among women in the United States. The high lethality of EOCs stems from rapid peritoneal involvement. EOCs frequently colonize peritoneal surfaces that overlie connective and adipose tissues. However, the mechanisms that …
-
Stromal interactions in pleural mesothelioma
… oncogenes. It is a stromal rich malignancy with cancer cell nuclei frequently accounting for less than 25% of all tumour nuclei. The remainder are largely comprised of stromal cells, the roles of which have been relatively neglected by existing studies. Of particular interest are the …
-
Interpreting transcriptional signatures and their relevance to disease biology, prognosis and treatment resistance in colorectal cancer
Introduction <br/>Colourectal cancer (CRC) is a common heterogeneous malignancy with a number of different disease subtypes influenced by distinct biology. The clinical implications of this disease heterogeneity are likely to influence treatment strategies further in the future. Therefore, patient …
-
Host-intrinsic factors determine anti-tumor efficacy of exercise in pancreatic ductal adenocarcinoma
… (PDAC) is the third leading cause of cancer-related deaths with a low 5-year relative survival rate of approximately 13.3% for all stages combined. We have previously shown that exercise can improve quality of life and enhance functional capacity among patients with PDAC. Exercise …
-
The role of tissue-resident immune cells in PanIN to PDAC progression
… (PDAC) is one of the leading causes of cancer deaths worldwide. PDAC is recalcitrant to current immunotherapies, largely due to local suppression of anti-tumour immunity. Tissue-resident group 2 innate lymphoid cells (ILC2) are emerging as important immune modulators of the cancer …
-
Dissecting the impact of SMAD4 loss and KRAS mutations in pancreatic ductal adenocarcinoma
… to make this disease the second leading cause of cancer-related deaths by 2040. Poor survival rates for PDAC are a consequence of late-stage diagnosis due to non-specific early-stage symptoms, and largely ineffective treatment options. Treatments are ineffectual particularly for advanced disease …
-
Cancer Associated Fibroblast Derived Angiogenic Factor Mfap5 In Ovarian Cancer Progression
<p>Advanced stage ovarian cancer is the most lethal gynecologic malignancy. No major improvement on patient survival has been achieved in the past decade. Therefore, identification of predictive or prognostic markers and further understanding of the molecular mechanisms in ovarian cancer …
Page 1 of 3