Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"cancer vaccines"”.
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Structure-guided Cancer Vaccines based on Glycopeptides Supported on Diverse Nanoparticles
Cancer is a worldwide problem and various cancer therapies are emerging as potential solutions. Among these cancer therapies, a very attractive strategy is that of therapeutic cancer vaccines, which can use tumor-associated peptide fragments that can induce an immune response. In this thesis, we …
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Streptavidin-cytokine fusion proteins for use as adjuvants in cancer vaccines
… antitumour response of a patient with cancer to immunotherapy. The response of breast cancer patients to cancer vaccines directed against tumour associated antigens, such as HER2/neu, is often weak and it has been reported that additional immunostimulation, such as that provided by an …
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Bacterial outer membrane vesicles (OMVs) as a platform for personalized cancer vaccines
Cancer is the second leading cause of death worldwide. Tumor cells contain several mutations that can generate neoepitopes, targets of an effective anti-cancer T cell response. Increasing evidence demonstrated that cancer vaccines targeting neoepitopes are effective and safe both in preclinical …
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Assessment of immunological responses to tumour antigens relevant to the development of therapeutic cancer vaccines
… occurring in more than 50% of all types of human cancers, mostly via point mutations. This very common genetic event is often associated with trans-dominant suppression of the wild type (wt) p53 or gain of oncogenic function independent of the wt protein. A wide range of p53 mutations are …
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Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines
… with promising implications for personalized cancer vaccines. The CD74-NRG1 fusion, resulting from a translocation between chromosomes 5 and 8, creates a unique fusion junction that disrupts cell signaling and drives tumorigenesis. This novel antigenic sequence, absent in healthy cells, …
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Construction and characterization of proteome-minimized OMVs from E. coli and their exploitation in infectious disease and cancer vaccines
Bacterial Outer Membrane Vesicles (OMVs) are naturally produced by all Gram-negative bacteria and play a key role in their biology and pathogenesis. Over the last few years, OMVs have become an increasingly attractive vaccine platform for three main reasons. First, they contain several …
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Knockout of the trans-acting riboswitches in Listeria monocytogenes to disrupt downstream virulence factors
… mechanisms can be exploited to produce a cancer vaccine. Currently L. monocytogenes is being studied as a viable candidate for various other cancer vaccines and therapies. The purpose of this study is to reduce the downstream virulence factors that heavily rely on upregulation of the prfA …
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Layer-by-layer coated microneedles for cancer immunotherapy
… the past few decades, research in therapeutic cancer vaccines has achieved remarkable advances in both pre-clinical and clinical studies. However, strategies to boost antigen presentation and T cell priming in order to increase the fraction of patients responding to immunotherapy remains an …
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Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
… progresses in vaccinology, therapeutic cancer vaccines have not achieved their full potential. We previously showed that the duration of antigen presentation critically affected the quantity and quality of T cell response and subsequent anti‐tumor efficacy. Here we describe L‐tyrosine …
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NOVEL RNA-BASED CANCER VACCINE FOR AML IMMUNOTHERAPY
… We hypothesize that personalized mRNA cancer vaccine can be a viable treatment strategy for AML patients. Using mouse AML cell lines, we have found candidate neoepitopes within intron polyadenylation sites, retained-intron sites, and somatic mutation sites. Screen for immunogenic …
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
Cancer vaccines targeting patient-derived neoantigens offer great promise for personalized cancer therapy but face challenges in achieving targeted delivery to antigen-presenting cells (APCs) to elicit robust and durable cancer-specific immune responses. We synthesized an anti-mouse CD40 …
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Therapeutic applications of DNA origami-based programmable nanoparticles
… the therapeutic utility of DNA origami for cancer and infectious diseases. First, we demonstrate that modulating the nanoscale arrangement of an adjuvant enhances the efficacy of cancer vaccines. Second, we demonstrate that this DNA origami nanoparticle can be used as a modular delivery …
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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… of continued antigen exposure. Given that many cancer cells lack antigens capable of effectively engaging with TCRs, it is important to understand whether and how TCR engagement strength regulates the preservation of Tpex and their terminal differentiation during tumor progression. To …
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Experimental brain tumors, dendritic cells and immunotherapy
… we did not observe any benefit of using DC-based vaccines alone regardless of antigen loading or maturation methods compared to immunotherapy with IFN-γ-producing tumor cells. In conclusion, we have demonstrated that DC-based vaccines fail to provide protection in a weakly immunogenic brain tumor …
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
Cancer vaccines have evolved as a new treatment modality to eradicate cancer and has gained in popularity since the approval of Provenge® vaccine. By activating antigen-presenting cells (APCs), which, in turn, activate innate or adaptive immune responses, immunoadjuvants have become promising tools …
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Investigation of the immunostimulatory activity and vaccine potential of lipid encapsulated plasmid DNA and oligodeoxynucleoties
DNA vaccines offer unique promise as a means of generating immunity against infectious and malignant disease. Unfortunately a number of obstacles, including rapid degradation of naked plasmid DNA (pDNA), poor cellular uptake by antigen presenting cells (APCs) and subsequent low levels of gene …
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Improving efficacy of therapeutics by enhancing delivery using chemical engineering
… many older modalities for therapeutics, such as vaccines and chemotherapeutics, could become more efficacious with optimization of delivery. By using chemical engineering principles, we can develop better delivery methods, materials, and formulations to improve the treatment of a wide range of …
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Synthesis and functionalisation of metal and metal oxide nanoparticles for theranostics
… that SPIO could be successful as a vector for cancer vaccines.
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… for protection and treatment with regards to cancer vaccines and viral infections, including HIV. The potency of resting CTLs in LFS immunized mice was investigated with a viral LCMV challenge months after a single immunization. Following the viral challenge, LFS-immunized mice had a much …
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Cooperativity: Physiologic Cornerstone and Emerging Therapeutic Design Principle
The content of this work is based on the previously published articles that are cited below.
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