Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"cancer targeting"”.
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RGD based peptide amphiphiles as drug carriers for cancer targeting
… receptors is one of the approaches for active targeting of anticancer drugs to cancer cells. Over expression of integrin receptors is a physiological manifestation in several cancers and is associated with cancer progression and metastasis, which makes it an attractive target for cancer …
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Controlled metabolic cell labeling and bioorthogonal click chemistry for cancer targeting
… research is to develop a new, transformative cancer targeted therapy via the combination of unnatural sugar-mediated controlled metabolic cell labeling and bioorthogonal Click chemistry. By controlling the metabolic glycoengineering processes of unnatural sugars via rational chemistry designs, …
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Investigating the size effect of nanoparticles in Click Chemistry mediated cancer targeting
… tumour tissue. The effect of NP size on tumour targeting has been studied in various contexts, with or without a targeting mechanism incorporated. Herein, we report our investigation of the size effect of NPs in Click Chemistry mediated cancer targeting. Realized by anchoring NPs onto the cell …
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Curcumin: A Multi-dimensional Approach to Pancreatic Cancer Targeting Cell Death and Exosomes
<p>Pancreatic cancer is currently one of the most difficult diseases to treat due to difficulty of detection and the aggressive nature of the disease. In addition, pancreatic cancer has the highest mortality rates compared to other cancer types. These mortality rates are attributable in part to …
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Synthesis and evaluation of novel non-viral gene delivery systems for prostate cancer targeting
Prostate cancer is the second most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal and radiotherapy that commonly have deleterious side effects and vary in their efficacy, depending on the stage of the disease. Among novel experimental strategies, gene …
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The Development of a Cancer-Targeting Peptide-Drug Conjugate for the Treatment of Melanoma
<p>Cancer is an ongoing global pandemic which has caused a dramatic shift in research priorities. One of the most aggressive and difficult to treat has invariably remained metastatic melanoma. Although encompassing only 4% of overall skin cancer diagnoses, chances for recovery were slim until …
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A cancer-targeting liposomal delivery system for photodynamic diagnosis and therapy of cancers in peritoneal cavity
… tumor is not named after the originating of cancer cells but instead contains all tumors appearing in the region of the peritoneal cavity. There are over 250,000 new cases of malignant diseases originating from organs in the peritoneal cavity annually in the USA, and most of these cases …
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Angiotensin-(1-7): A Peptide Hormone Inhibitor for the Treatment of Breast Cancer Targeting the Tumor Microenvironment
In 2009, 192,000 new cases of breast cancer were diagnosed in the United States and over 40,000 American women died from breast cancer, emphasizing the severity of the breast cancer epidemic. Recent advances in molecular profiling of breast tumors have identified three clinically-relevant …
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Poly(Arginine) Derived Cancer-Targeting Peptides for the Development of a Cancer-Targeted Gene Therapy Approach in HepG2 Liver Cancer Cells
<p>Cancer is a disease that has eluded medicinal approaches for many years and as a result new and improved therapeutic approaches are in constant demand. Although chemotherapy and radiation treatments have assisted in suppressing the growth of tumors, their poor selectivity and efficacy are major …
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Branching into RNAi: Synthesis, Characterization and Biology of Branch and Hyperbranch siRNAs
<p>The cancer epidemic continues to afflict millions of humans world-wide each year and despite a renewed hope with the development of new and improved forms of therapy, a cure for cancer remains an elusive goal. This is partly related to the rise of resilient forms of tumors that have evolved with …
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
… improve the physicochemical property of the anticancer drug. Therefore, we have designed and synthesized various conjugates of anticancer drugs with cancer- targeting peptides using established biomarkers of cancer such as the integrin receptor and extra-domain of fibronectin (EDB-FN) at the …
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Engineering M13 bacteriophage platforms for cancer therapy applications
… therapy and imaging agents and target specific cancer sites. Now with the ability to control the aspect ratio of these rigid, rod-like phages we can further improve on M13 based cancer detection by optimizing for phage blood circulation and tumor extravasation. Secondly, we have added to our …
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Ionic Liquids and GUMBOS for Biomedical and Sensing Applications
… applications, especially with regard to cancer research. The toxicity of chemotherapeutic agents to normal tissues and drug resistance are a major concern in cancer treatment. In this dissertation, GUMBOS and nanoGUMBOS as well as ionic liquids and nanodroplets are explored as possible …
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Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamoxifen therapy. However, resistance to tamoxifen is often observed and possible mechanisms may be loss or reduction of ER, dysfunctional ER- signaling and ligand independent activation of the …
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Improving efficacy of therapeutics by enhancing delivery using chemical engineering
… thesis, I report on applications to vaccines and cancer. Vaccines are currently the vanguard of public health efforts; unfortunately, a wide range of diseases have no effective vaccine. This includes devastating diseases such as HIV, malaria, and others. One area of vaccination that few people …
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Exploring Critical Vehicle Parameters for the Design of Multitargeted Nanoparticles for Cancer Specific Gene Delivery
The greatest obstacle to clinical application of cancer gene therapy is lack of effective delivery tools. Gene delivery vehicles must protect against degradation, avoid immunogenic effects and prevent off target delivery which can cause harmful side effects. The stealth liposomes has greatly …
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Targeting GRP78 in Cancer with Nucleic Acid Bioconjugates
… aimed at fighting human malignancies such as cancer, diabetes, genetic and infectious diseases. Their popularity stems from their ability to accelerate the drug development process by conjugating chemical functionality that may improve the pharmacology of a bioactive nucleoside. Moreover, this …
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Selective in vivo metabolic labeling for cell targeting and immune regulation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Expanding cancer therapy options through genome-scale identification of synthetic lethal paralogs
… lethal therapies have the potential to expand cancer treatment options. Synthetic lethality is a form of context-dependent gene essentiality in which dual inactivation of a gene pair leads to cell death but single-gene inactivation does not affect viability. When one synthetic lethal gene is …
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Role of the extracellular matrix-integrin interaction in enzalutamide resistance of bone metastatic castration-resistant prostate cancer
Bone metastatic castration-resistant prostate cancer (bone mCRPC) is the most prevalent type of prostate cancer metastasis, accounting for 90% of all metastasis incidence. Its resistance to androgen-deprivation therapy (ADT). Enzalutamide (Enz) is a second-generation androgen-receptor (AR) …
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