Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"cancer study"”.
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Pulse electric field effect on cervical cancer cell: a plant based anti-cancer study
Cancer is listed in top ten global causes of death in 2016. The percentage of cancer incidence and mortality are steadily rising over the year. This necessitates alternate anti-cancer treatment as the conventional treatment have resulted in high number of long- term survivors who are left to deal …
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Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome
… PMS2). The identification of MMR defective colon cancer is clinically relevant for diagnostic, prognostic and potentially also for treatment-predictive purposes. The aims of this thesis were to validate the application of the MMR index for the prediction of MMR deficiency in colon cancer (study …
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Human papillomaviruses in skin cancer and cervical cancer
… papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated whether seropositivity to cutaneous HPV is a marker for cutaneous …
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Sparse selection in Cox models with functional predictors
… we may locate a gene that is associated to cancer risk along a chromosome. The functional linear regression method is widely used for the analysis of functional covariates. However, it could lack interpretability. The method we develop in this thesis has straightforward interpretation since …
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Gender Differences in Depression and Immune Response in Colorectal Cancer
The focus of this descriptive comparative study was to examine the relationship between gender and depression and immune system function in patients with colorectal cancer. The research questions were answered through secondary analysis, using data obtained from the answers of 117 men and women (71 …
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The Use of Proteomic Technologies to Identify Serum Glycoproteins for the Early Detection of Liver and Prostate Cancers
… protein patterns as shown herein with the HCC study of chapter II, it was unable to offer sequence information on the selected peaks, and did not have the ability to analyze the entire dynamic range of the serum/plasma proteome. To address these deficiencies, new strategies that incorporate the …
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Calcium metabolism and breast cancer risk
… D and parathyroid hormone (PTH), affect breast cancer risk. The associations between serum calcium levels and breast cancer risk, between serum calcium levels and known risk factors of breast cancer, and between serum calcium levels and breast cancer aggressiveness were examined within the Malmö …
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Clinical and epidemiologic aspects of Rheumatoid Arthritis. Special emphasis on cardiovascular outcome and risk factors
… CVD over time and, using immunohistochemistry, study markers of inflammation in vascular endothelial cells during treatment with a TNF-inhibitor. We also investigated predictors of RA. Two community based of RA cohorts were established in 1978 and 1995 and compared to the corresponding …
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Bayesian Modeling of Complex High-Dimensional Data
… two datasets, a mass spectrometry dataset in a cancer study and a neuroimaging dataset in an Alzheimer's disease study. The second part is about modeling data heterogeneity by using Dirichlet Diffusion Trees. We propose a Bayesian latent tree model that incorporates covariates of subjects to …
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The Development and Evaluation of Non-invasive Methods to Characterise the Disease States of Patients Utilising Selective Discrimination, Gas Chromatography-Mass Spectrometry and Chemometrics
… (VOCs). Dogs were first reported to detect cancer in 2004. Increasingly, the profiles of VOCs are being utilised as non-invasive diagnostic methods. The aim of the thesis was to develop and evaluate the performance of analytical methods to characterise the disease states of patients …
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Biologically Interpretable, Integrative Deep Learning for Cancer Survival Analysis
… sparse deep neural networks (PASNet) for cancer survival analysis. PASNet family is a biologically interpretable neural network model where nodes in the network correspond to specific genes and pathways, while capturing nonlinear and hierarchical effects of biological pathways associated …
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A Pan-Cancer Single-Cell Analysis of Intratumoral Copy Number Diversity and Evolution
<p>Aneuploidy is a hallmark of human cancers, with many copy number aberrations (CNAs) being associated with disease progression. Previous studies have revealed extensive inter-patient heterogeneity (IPH) in copy number profiles. However, the extent of intratumoral heterogeneity (ITH) and its …
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Influence of missing explanatory variables and longitudinal assessments in breast cancer clinical trials
Clinical trials in breast cancer assess treatment regimens based on a balance of efficacy and adverse effects. To achieve high-quality evidence for these assessments, it is important to minimise potential sources of bias. Therefore, potential bias in the parameter estimates resulting from missing …
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The Intra-Tumour Heterogeneity Landscape of Human Cancers
… whole genome sequences in the International Cancer Genome Consortium Pan-Cancer Analysis of Whole Genomes initiative to paint the pan-cancer landscape of intra-tumour heterogeneity. I will first introduce the methods; a method to call somatic copy number alterations (Battenberg) and a method …
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A 3D Computational Fluid Dynamics Model Validation for Candidate Molybdenum-99 Target Geometry
… this product include detection of heart disease, cancer, study of organ structure and function, and other applications. 99Mo has a short half-life (66 hours) and cannot be stockpiled. U.S. demand is approximately 50% of the world market. The objective of the domestic 99Mo project is to accelerate …
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Bayes Multiple Decision Functions: Theory, Computation and Application
… of two real microarray data sets from a colon cancer study.</p>
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Semiparametric and nonparametric methods for the analysis of panel count data
… recurrent events. Ideally for an event-history study, subjects should be monitored continuously, so for the events that may happen recurrently over time, the exact time of each event occurrence is recordable. Data obtained in such cases are commonly referred to as recurrent event data (Cook and …
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Hormonal factors in rheumatoid arthritis – Their impact on disease risk and severity
… programme, (MPMP)) and 1991-1996 (Malmö diet and cancer study (MDCS), respectively). Participants answered a questionnaire and blood samples were collected. We identified incident cases of RA by linking the cohorts to four different RA registers. In nested case-control studies, we studied hormonal …
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Novel risk factors for atrial fibrillation in an urban population
… III-IV included subjects from the Malmö Diet and Cancer Study (n=30 477, aged 44-74 years), followed during mean follow-up of 13.6 and 15.3 years respectively. Cases of incident AF were retrieved by linkage with the Swedish Hospital Discharge Register and the Swedish Cause of Death Register. …
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Mammographic density in relation to breast cancer Tumor characteristics, mode of detection, and density assessments
… dense breasts have a higher incidence of breast cancer than do women with non–dense breasts. Furthermore, there has been an increased interest in improving the measurement of mammographic density. The aim of this thesis was to study how mammographic density relates to breast cancer in terms of …
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