Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"cancer studies"”.
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Cervical cancer studies on prevention and treatment
Cervical cancer is the fourth most common reason for cancer death amongst women worldwide, with 500 000 new cases every year. Most of these women live in developing countries. Cervical screening programs can reduce the incidence by 50%, but are not common in the developing world. In Sweden there …
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Microarray-based gene set analysis in cancer studies
… of biological mechanisms underlying breast cancer recurrence. In the third part, statistical models for analyzing combined microarray-based expression and genomic copy number data are developed. In addition, an analysis which incorporates tumour subgroups is shown to provide more accurate …
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The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
… antiproliferative effects on a variety of human cancers, including breast cancer. Studies have shown that a combination approach to cancer treatment is more effective than any one treatment administered alone. In this study, human mammary epithelial cells from the MCF-7 cell line were treated …
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Harnessing Cancer Omics to Inform Precision Oncology
… era of big data. With the growing size of pan-cancer genomic, transcriptomic and proteomic profiling data, there is imperative need for integrative analysis of molecular and clinical information in an efficient way. Here, we conducted omics analysis on three different cancer studies and …
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Gene Selection and Cancer Classification Using a Multidimensional Fuzzy Deep Learning Approach for Gene Expression Data
… techniques commonly employed for developing cancer prediction models using associated gene expression and mutation data. This thesis provides a comprehensive review of recent cancer studies that have employed gene expression data from several cancer types (i.e Breast, Lung, Kidney, Liver, …
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Role of IGF-II, PRL, and FABPs in the Breast Cancer Disparity among AA Women
… present with more advanced states of breast cancer and have lower survival rates than Caucasian-Americans (CA). Epidemiological data have shown that pregnancy and lactation at an early age in humans reduce the risk of breast cancer. Studies in mice and rats have shown that lactation …
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Quantitative analysis of co-enzyme a in a plant tissues and cancer biomarkers in urine samples by using capillary electrophoresis and liquid chromatography-mass spectrometry
<p>"Despite continuous effort and progress in cancer detection and therapy, cancer remains one of our greatest health concerns because of its low survival rate and rapid incidence increase. One reason for this is the late detection and therefore pre-cancer diagnosis is crucial. In pre-cancer …
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The phenomenon of coping for women with primary breast cancer
… during and after a diagnosis of primary breast cancer. This experience was reported as a significant life event for all participants, requiring flexible use of different coping styles to adjust to the global disruption in their lives. The interview questions for the study used the existential …
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
… fifth most common and second most deadly form of cancer.1-3 Many genes deregulated by the hepatitis B x-antigen (HBx), the oncogenic protein encoded by HBV, are known drivers of HCC.4,5 The timing of these alterations in the initiation and progression of disease, however, are poorly understood and …
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Chemical and Biological Strategies for Improving the Sensitivity of SPIO-Enhanced MR Imaging
The prevalence of cancer has seen significant growth over the last three decades, with the American Cancer Society now reporting that one in every three Americans will be afflicted with some form of cancer in their lifetime. The debilitating effects of cancer permeate beyond obvious biological …
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Protein structural and functional consequences of missense mutations in the human cancer genome
… addressed, and it is particularly prevalent in cancer. The replication and repair mechanisms of tumour cells are defective, causing an extremely chaotic and messy mutational landscape, where the contribution of most variants to tumour progression cannot be quantified easily. There are some key …
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An improved directed random walk framework for cancer classification using gene expression data
Early diagnosis methods in cancer diagnosis studies are making great challenge as they require the involvement of different fields. Deoxyribonucleic acid (DNA) microarray analysis is one of the modern cancer diagnosis techniques used by scientists to measure the gene expression level changes in …
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Human papillomaviruses in skin cancer and cervical cancer
… papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated whether seropositivity to cutaneous HPV is a marker for cutaneous …
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Mathematical modelling of cancer cell invasion of tissue: discrete and continuum approaches to studying the central role of adhesion
… adhesion, plays an important role in cancer invasion and metastasis. After undergoing morphological changes malignant and invasive tumour cells, i.e., cancer cells, break away from the primary tumour by loss of cell-cell adhesion, degrade their basement membrane and migrate through the …
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Reconstruction Methods for Optical Molecular Tomography
… or enable preclinical applications such as cancer studies, involving angiogenesis, tumor growth, cell motility, metastasis, and interaction with a micro-environment. The reconstruction of diffuse light sources is the central task of optical molecular tomography, and generally ill-posed and …
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Beta-Lapachone Nanotherapeutics for Lung Cancer Therapy
A rising trend in lung cancer chemotherapy involves the development of agents that exploit molecular targets overexpressed in tumors, with hopes of increasing specificity, and in turn, efficacy. β-Lapachone (β-lap) is a novel anticancer drug whose mechanism of action relies on its bioactivation by …
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
… metabolic syndrome, and liver and colon cancer. Studies suggest epigenetic mechanisms are critical for proper transcriptional induction of nuclear receptors. Likewise, evidence shows epigenetic mechanisms are responsible for modulating the tissue/cell-specific FXR expression in human …
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Platinum-NGR A Peptide Targeting Conjugate Of Cisplatin: Design, Synthesis, And Efficacy In Breast Cancer Cells
<p>Breast cancer is one of the leading causes of mortality in women worldwide. Platinum based chemotherapeutic drugs, such as cisplatin and carboplatin, are one of the primary therapies employed in the treatment of breast cancer. Adverse side effects caused by untargeted drug delivery of these …
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Genomic Characterization of Adolescent and Young Adult Cancers: Investigation of Ewing Sarcoma Susceptibility and Chornobyl Thyroid Tumors
<p>Adolescent and young adult (AYA) cancers, diagnosed between the ages of 15 and 39, can exhibit distinctive genetic and molecular characteristics. Reported epidemiologic findings and treatment outcomes based on pediatric and adult cancer studies are often not suitable for application to the AYA …
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