Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"cancer stem cell"”.
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EXAMINATION OF CD133 AND CD147 AS CANCER STEM CELL MARKERS
… therapies is imperative. A population of cells with stem cell-like properties are found within glioblastoma tumors and drive their initiation and progression. Identification of extracellular markers on these tumor stem cells is thus paramount. The cell surface glycoproteins CD133 and CD147 …
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway
A major problem in prostate cancer is the high relapse rate post therapy. This is believed to be due to the presence of a small number of prostate cancer stem cells within a tumour. Tumour initiation, maintenance and spreading have been attributed to this subpopulation of tumour cells. Wnt activity …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… used for risk stratification in prostate cancer (PCa), but they present some limitations in the prediction of disease progression and in their use to guide clinical decision making. Prostate cancer stem cells (PCSCs) are widely considered to be responsible for tumorigenesis, disease …
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Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell and Gene Therapy
… chronic hepatitis cirrhosis, steatosis and hepatocellular carcinoma (HCC) worldwide. Although current FDA-approved drugs are partially effective in the treatment of HCV, methods for cure and vaccine against the virus are still awaited. My thesis work presented here is focused on finding mechanism …
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MiR-10a Regulation of Drug Response and Cancer Stem Cell Populations in Non-Small Cell Lung Carcinomas
… (PI3Ks) are enzymes involved in diverse cellular functions including cell growth, proliferation, differentiation, motility, survival and apoptosis. Many of these functions relate to class I PI3Ks, heterodimers composed of regulatory and catalytic subunits that convert extracellular cues …
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DELINEATING REGULATORY PATHWAYS OF NOVEL CANCER STEM CELL MARKER, DCLK1-S, FOR TARGETING COLON CANCER STEM CELLS
Colon cancer is third most prevalent cancer in the United States, with significant health consequences for the patient and society. Cancer stem cells are believed to be resistant to conventional treatments resulting in relapse of the disease. Targeting cancer stem cells in addition to conventional …
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Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population
<p>Numerous studies have identified stem-like cells, termed cancer stem cells (CSCs), in breast tumors and established cell lines. It has been hypothesized that CSCs are responsible for breast cancer formation, progression and recurrence; therefore, a deeper understanding of the signaling pathways …
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Development of a reversible quiescence model to identify signals enabling glioblastoma cancer stem cell transition between active and quiescent states
… with only limited therapies available. Glioma stem cells (GSCs) are a subpopulation with tumorigenic capacity associated with increased glioma malignancy, particularly in glioblastoma (GBM), the most frequent and aggressive adult glioma (1). GSCs can enter a non-proliferative reversible …
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Gsk3B Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties and Is A Novel Drug Target For Triple-Negative Breast Cancer
… regulates Epithelial-Mesenchymal-Transition and Cancer Stem Cell properties and is a novel drug target for Triple-Negative Breast Cancer.</strong></p> <p>Geraldine Vidhya Raja, MS.</p> <p>Advisory Professor: Sendurai Mani, Ph.D.</p> <p>Triple-Negative breast cancers (TNBCs) are highly aggressive …
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Peptide microarrays for the discovery of cell-ligand interactions that direct cell state
During development, cells receive many cues from their environment. These cues, whether physical or chemical in nature, are able to regulate the behavior of cells from macroscale levels such as tissue organization, to microscale levels such as gene modifications. Synthetic materials are able to …
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An examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumors
… epithelial to mesenchymal transition (EMT) and cancer stem cells (CSC) in solid tumors. Epithelial to mesenchymal transition describes the conversion of cancer cells from an adherent, differentiated, and polar phenotype (epithelial) to a motile, plastic, and apolar phenotype (mesenchymal). EMT …
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Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer
In recent years, the cancer stem cell hypothesis has emerged as a compelling but controversial model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are hierarchical and only a rare subpopulation of …
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
… Recent mapping of the GBM genome by the Cancer Genome Atlas Network revealed that these cancers commonly exhibit several signature mutations that promote gliomagenesis (e.g. EGFR amplification/activation, PTEN loss, p53 loss, Ink4a/Arf loss). How these genetic changes may modulate …
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Polyclonal interactions in intestinal tumorigenesis
… sequence posits that colorectal cancers result from the stepwise accumulation of mutations in a number of cancer driver genes, with mutations in the tumour suppressor gene \textit{APC} thought to be necessary and sufficient for transformation. However, large-scale sequencing …
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Identification and Characterization of Her2/Neu-Transformed Breast Cancer Stem Cells
… variety of human solid tumors, including breast cancer, are considered to embrace a hierarchical organization in which only infrequent tumor-initiating cancer stem cells are truly responsible for tumor formation rather than the non-tumorigenic majority. However, these cancer stem cells remain …
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Activity-based sensors for reactive aldehydes and their corresponding enzymatic machinery
… active enzyme. Activity-based sensors are also excellent sensors for reactive small molecules with unique chemical reactivity. Here, we report the development and/or progress on activity-based sensors for reactive biological aldehydes and the enzymatic machinery tasked with aldehyde metabolism. We …
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Microenvironmental Modulation of Breast Cancer Stem Cells Through Biological Matrix
<p> Breast cancer is the second leading cause of death among American women and almost 12.5% of the women are diagnosed with invasive breast cancer in the course of her lifetime. Recent advancement in breast cancer research has identified a rare, highly tumorigenic population of cells within tumors …
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