Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"cancer spectrum"”.
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Elucidation of the pathways underlying the spectrum of cancers affecting different tissues in lynch syndrome
… individuals to an increased risk of several cancers, particularly colorectal cancer (CRC) and endometrial cancer (EC). LS arises from constitutional (“germline”) pathogenic variants affecting one of four DNA mismatch repair (MMR) genes. When coupled with somatic mutations (“second hits”) in …
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Cancers Associated With Brca1 and Brca2 Mutations Other Than Breast and Ovarian
… development in Hereditary Breast and Ovarian Cancer syndrome (HBOC) through accumulation of unrepaired DNA damage. Extensive research of <em>BRCA1</em> and <em>BRCA2</em> mutations has led to well-defined breast and ovarian cancer risks in individuals with HBOC. Previous studies have reported …
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Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers
… risks for breast, ovarian, and several other cancers. The purpose of this study was to evaluate the incidence of cancers in first and second degree relatives of <em>BRCA</em> mutation carriers compared to the general population. A total of 1086 pedigrees of <em>BRCA</em> mutation carriers were …