Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"cancer radiotherapy"”.
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Treatment Planning Automation For Rectal Cancer Radiotherapy
<h2>Background</h2> <p>Rectal cancer is a common type of cancer. There is an acute health disparity across the globe where a significant population of the world lack adequate access to radiotherapy treatments which is a part of the standard of care for rectal cancers. Safe radiotherapy treatments …
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Artificial Intelligence (AI)-assisted Cardiotoxicity Management in Lung Cancer Radiotherapy
<p>Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with radiation therapy being a cornerstone of treatment. However, radiation-induced cardiotoxicity has emerged as a significant long-term complication, impacting patient survival and quality of life. There is …
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Evaluating and Improving 4D-CT Image Segmentation for Lung Cancer Radiotherapy
Lung cancer is a high-incidence disease with low survival despite surgical advances and concurrent chemo-radiotherapy strategies. Image-guided radiotherapy provides for treatment measures, however, significant challenges exist for imaging, treatment planning, and delivery of radiation due to the …
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Multiparametric Magnetic Resonance Imaging Artificial Intelligence Pipeline For Oropharyngeal Cancer Radiotherapy Treatment Guidance
<p>Oropharyngeal cancer (OPC) is a widespread disease and one of the few domestic cancers that is rising in incidence. Radiographic images are crucial for assessment of OPC and aid in radiotherapy (RT) treatment. However, RT planning with conventional imaging approaches requires operator-dependent …
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Interaction of amphiphilic gold nanoparticles with lipid membranes and their application to cancer radiotherapy
Striped gold nanoparticles (NPs), inorganic particles protected by an amphiphilic mixed organic ligand shell, are the most recent and potent evolution of gold nanoparticle intracellular delivery vectors. Here we propose the combination of striped gold nanoparticles with lipid vesicles of diameter < …
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A pilot study to identify links between genetic variation and shoulder pain and dysfunction after breast cancer radiotherapy
Introduction – Treatment for breast cancer is associated with a risk of chronic shoulder and upper limb morbidity in up to 30% of patients. There is currently no consensus for the possible reason for this often repeated finding in the literature. Previous research has suggested that development of …
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Accumulating delivered dose to the rectum to improve toxicity prediction in prostate radiotherapy
… to improve toxicity prediction in prostate radiotherapy Leila E. A. Shelley Gastrointestinal (GI) toxicity is a clinical issue suffered by up to 22% of prostate cancer radiotherapy patients. However, the relationship between radiation dose and toxicity is generally poorly understood. In …
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Effects of Therapeutic Radiation on Polymeric Scaffolds
… as x-rays, are commonly used in the treatment of cancers. Material characterization has not been fully explored for polymeric materials exposed to therapeutic radiation levels. This study investigated the effects of therapeutic radiation on three porous scaffolds: polycaprolactone (PCL), …
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CHARACTERIZATION OF BREAST RT TREATMENT BY MULTI-INSTITUTIONAL AI-KNOWLEDGE-BASED PLANNING OPTIMIZATION MODELS
… at Risk, particularly the heart, in breast cancer radiotherapy. The goal is to enable physicists to quickly assess, via computed tomography (CT), whether a tangential field plan is adequate or if alternative techniques, such as breath-hold CT or Volumetric Modulated Arc Therapy (VMAT), are …
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Experiences and factors influencing the use of dilators by women with cancer who received pelvic radiotherapy at cancer diseases hospital in Lusaka, Zambia.
Cancer of the cervix is one of the commonest cancers among women seen at Cancer Diseases Hospital in Lusaka, Zambia. Pelvic Radiotherapy is the main treatment modality used on Cervical Cancer patients. Pelvic Radiotherapy causes vaginal stenosis in women, but this stenosis can be prevented by …
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Investigation of Respiratory Motion Management Techniques For Proton and Photon Radiotherapy of Lung Cancer
… proton and photon dose distributions during lung cancer radiotherapy. The goals of this dissertation research were to evaluate the impact of respiratory motion and to estimate the benefit of respiratory gating for passively scattered proton therapy (PSPT) and intensity modulated photon therapy …
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Effects of Advanced Radiotherapy techniques on Normal Tissue Toxicity in Breast Cancer
Whole breast radiotherapy after breast conserving surgery is an effective adjuvant treatment, but is associated with some long-term side effects and breast tissue toxicities including breast shrinkage, breast fibrosis, skin changes and poor overall cosmesis. These breast-specific complications can …
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Bioastronautics: Biological Modeling of the Neural Response to Space Radiation and its interaction with Alzheimer's Disease Risk Genes
… interactions of low dose - and in the case of cancer radiotherapy not so low dose - radiation exposure. 93The goal of this dissertation is to explore and develop both new and existing in vitro neural models for radiation research – particularly in the context of neurodegenerative disease. …
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Predictive Modelling Approach to Data-Driven Computational Preventive Medicine
… fat-associated diseases and advanced breast cancer radiotherapy toxicity side effects. These contributions could be used to guide future theories, experiments and healthcare interventions in preventive medicine and data mining.
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Development of Automated Radiotherapy Treatment Planning For Cervical and Breast Cancer For Resource-Constrained Clinics
<p>Globally, cancer rates are on the rise, especially in low- and middle-income countries (LMICs). However, many of these countries lack access to radiotherapy, which is due in part to a substantial shortage of the staff necessary to deliver safe and effective radiotherapy. This staff shortage …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
One of the major focus areas of anticancer therapy is the design of new radiotherapeutic agents that are able to specifically target and destroy cancer cells with minimal side effects and damage to healthy, normal cells. This thesis describes studies towards the synthesis of a macromolecular …
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Knowledge Deficits of Radation Therapy Patients in a Rural Setting: A Pilot Study
… an outpatient Radiation Therapy clinic for cancer" treatment. The problem under investigation was:<br> What are the knowledge self-care deficits of patients receiving radiation therapy in a rural outpatient setting?<br> A better understanding of their needs may impact the kinds of …
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A Multi-DOF Soft Robot Mechanism for Patient Motion Correction and Beam Orientation Selection in Cancer Radiation Therapy
… radiation therapy is crucial for efficient cancer treatment. Good treatment outcomes require accurate patient immobilization and a good choice of beam orientations. State-of-the-art immobilization systems rely on metallic or rigid masks which lack morphological properties, attenuate ionizing …
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Radiation therapists’ experiences of disruptions in radiotherapy service delivery during the Covid-19 pandemic at public oncology hospitals in KwaZulu-Natal, South Africa
Dissertation submitted in fulfilment of the requirements for the Master of Health Sciences in Radiography at the Durban University of Technology, Durban, South Africa, 2024.
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