Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 385 for “"cancer progression"”.
-
Nherf1 – New Modifier of Colorectal Cancer Progression
Colorectal cancer (CRC) develops from multiple progressive modifications of normal intestinal epithelium into adenocarcinoma. Loss of cell polarity has been implicated as an early event in this process, but the molecular players involved are not well known. NHERF1 (Na+/H+ Exchanger Regulatory …
-
Sustained Adrenergic Signaling Promotes Cervical Cancer Progression
… adrenergic signaling are known to promote tumor progression. The underlying mechanisms behind this process are not well understood. We examined the effects of sustained adrenergic signaling on cervical cancer progression through increased expression of HPV oncogenes, E6 and E7.</p> <p>Materials …
-
ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… have been reported in a wide variety of cancers and blocking the lipogenic pathway by chemical inhibitors or RNA interference causes tumor cell death by apoptosis which provides a strong rationale for targeting lipogenic pathway for the treatment and prevention of cancer however the exact …
-
Extracellular Metabolic Energetics Can Promote Cancer Progression
<p>Colon cancer progression is characterized by growth of the primary tumor in the colon followed by metastasis to distant organs. The metastatic cascade involves invasion of cells from the primary tumor into the surrounding tissue, entering into and survival of cancer cells in the circulation, …
-
Adhesion-GPCRs in cancer progression and metastasis
… analyses of genetic alterations across diverse cancer types have revealed significant alterations (copy number and mutational) in adhesion-GPCRs, yet no comprehensive examination of their roles in cancer biology exists. Through a systematic screening for all adhesion-GPCRs by RT-qPCR in murine …
-
The Impact of Pleiotrophin on Breast Cancer Progression
Page xiv is misnumbered as page xv.
-
The Role of SOX2 in Colon Cancer Progression
… SOX2 is amplified in various types of epithelial cancers and its high its expression correlates with poor prognosis and decreased patient survival. Aberrant Wnt signaling drives the colo-rectal carcinogenic process and is a major determinant of the disease outcome. This study demonstrates that …
-
The Role of TBX3 In Early Breast Cancer Progression
… development and in tumorigenesis of several cancer types. There are two isoforms of TBX3 (TBX3iso1 and TBX3iso2) with different DNA binding domains. The large-scale functional roles of TBX3iso1 and TBX3iso2 were characterized in a breast cancer context. Both TBX3 isoforms induced invasiveness …
-
Breast Cancer Progression and Phytoestrogen Interactions with Estrogen Receptors
Breast cancer is one of the most common diseases affecting women and approximately 1.3 million females are diagnosed each year with this disease worldwide. Breast cancer is a multi-factorial disease and it is difficult to predict or control the physiopathology, to date one of the major risk factors …
-
Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
… have shown that TPα impacts tumor growth and progression of lung cancer. Previously our studies demonstrated that activation of Thromboxane receptor by TXA2 agonists could regulate prostate cancer (PCa) cell motility and cytoskeletal reorganization through activation of Rho-A. The primary …
-
Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… tissue differentiation and human tumor progression; with a focus on non-small cell lung cancers (NSCLC). The SUMO E3 ligase protein inhibitor of activated STAT-1 (PIAS1) is one the few known SUMO conjugating enzymes known to date. PIAS1 was first discovered as a negative regulator of …
-
Consequences of Pathogenic Mitochondrial DNA Mutations in Cancer Progression
… DNA (mtDNA) mutations are prevalent in human cancers; however, their functional impact on cancer progression remains controversial and uncertain. This uncertainty is primarily due to a lack of suitable models for controlled functional studies. This thesis addresses this limitation by …
-
Tissue Transglutaminase And Its Role In Human Cancer Progression
… expression is up-regulated in several human cancers. Here I show that tTG is a key participant in a novel EGFR/Src-signaling pathway and a potential target for inhibiting EGFR-promoted tumor progression. Specifically, EGF up-regulates tTG expression in human breast cancer cells, and …
-
The role of microRNA-194 in prostate cancer progression
Prostate cancer is a major cause of cancer-related mortality in Australia men. Mortality is primarily due to metastasis and the development of resistance to therapy. While prostate cancer is primarily driven by the androgen receptor signalling, a number of other factors play important roles in its …
-
Molecular determinants of mammary differentiation and breast cancer progression
… of these processes frequently results in progression toward cancer, and later, potentially metastatic disease. The clinical relevance of metastasis is hard to overstate, as it is responsible for over 90% of cancer-related deaths. In this thesis, I have identified a number of determinants …
-
Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
<p>Prostate cancer is the second leading cause of cancer death among American men. The American Cancer Society estimates that 180,890 men will be will be diagnosed with prostate cancer in 2016 in the USA. (http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-key-statistics). …
-
New Insights On The Role of Jmjd2A In Cancer Progression
… are known to be one of the underlying causes of cancer because of its ability to alter gene transcription. Histone methylation is one of the most intricate epigenetic marks because it adds multiple layers of modification on the targeted sites. Therefore, many studies have brought histone …
-
Role of ß-catenin and Leukotriene in Colon Cancer Progression
Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of …
-
Immunohistochemical and molecular studies on ovarian cancer progression and prognosis
Epithelial ovarian cancer (EOC) is the most lethal malignancy of the female reproductive tract. Due to vague symptomatology, the majority of EOC patients are diagnosed in advanced clinical stages with poor survival rates, despite improvements in surgical techniques and the advent of targeted …
Page 1 of 20