Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"cancer mouse models"”.
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Development and application of an imaging and spatially-driven toolkit to elucidate vasculogenic mimicry in breast cancer mouse models
… phase of this project was to apply it first to mouse models of VM, followed by human cancer cell line-derived mouse models, all in the triple negative breast cancer setting. The culmination of this PhD has yielded three impactful achievements. First is an optimised and validated novel toolkit …
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
… vaccine platform. The exploitation of OMVs in cancer immunotherapy was tested by decorating them with cancer epitopes and by following their capacity to elicit protective immune responses, alone or in combination, using cancer mouse models. Furthermore, we tested whether cancer cell-derived …
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Digital Profiling of Circulating Extracellular Vesicles at Single-Upconversion Nanoparticle Sensitivity and Resolution
… has been examined by two types of breast cancer mouse models. Our results suggest that the population of cancer-derived circulating EVs, detected and classified by the number of UCNPs, can be used to monitor the metastatic tumour progression, including non-metastasis/high-metastasis and …
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Identifying and Targeting Adaptive Changes to Bet Inhibition In Ovarian Cancer
… inhibitor combinations in pre-clinical ovarian cancer mouse models.</p> <p><strong>Experimental Design: </strong>We used a novel, previously uncharacterized pan-BET inhibitor, CN210, for all <em>in vitro</em> (MTT, apoptosis, protein expression, reverse phase protein array (RPPA) analysis and …
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A Molecular and In Vivo Investigation of Advanced Prostate Cancer: Deconstructing Ampk Activity and Developing An Improved Mouse Model
<p>Prostate cancer is one of the leading causes of cancer-related death in men. Prostate cancer is dependent on androgen receptor (AR)-mediated pathways, and AR is therefore targeted to treat advanced prostate cancer. Despite an initial response to current AR-targeted therapies, patients invariably …
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A broadened HLA ligandome uncovers new immunotherapy targets for pancreatic cancer + A prime editor mouse to model a broad spectrum of somatic mutations
Pancreatic cancer is a lethal malignancy recalcitrant to immune checkpoint blockade and other immunotherapies. A subset of tumors is computationally predicted to harbor potentially immunogenic peptides for MHC class I (MHC-I) presentation, but the nature, expression, and immunogenicity of these …
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Genetic dissection of EGFRvIII brain and spinal mouse gliomas through whole-exome sequencing and in vivo piggyBac mutagenesis forward genetic screening
Glioma is the commonest intrinsic brain tumor, and its high-grade form has a devastating prognosis. These tumors also arise in the spinal cord, carrying significant morbidity in children; however the genetics of these spinal gliomas is poorly understood. EGFRvIII is a common driver mutation in …
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Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
… emerging non-invasive, non-thermal, image-guided cancer ablation modality that has recently been approved for its first clinical trial in the United States (NCT04573881). Histotripsy utilizes focused ultrasound to generate acoustic cavitation within a tumor to mechanically fractionate targeted …
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DISSECTING THE FUNCTION AND INTERACTOME OF PLEKHS1 IN PROSTATE TUMORIGENESIS
… event in many human tumours, including prostate cancer. Mouse models in which Pten and/or Class I PI3K signalling can be conditionally deleted in the prostate have been developed and used to show that unrestrained Class IA PI3K signalling can drive over growth of tissues and eventually cancer. …
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Developing C–H bond Functionalization, Organocatalytic Hydrophosphination Reactions and Anti-Invasion Agents
… agents for the treatment of metastatic cancer. Metastasis remains the leading cause of anti-cancer treatment therapy and cancer-related death. The rapid spread and mutation of the cancerous cells complicates treatment and increases the chance of recurrence. Treatment options are limited …
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Evaluating CD44-EZRIN Interactions in Triple-Negative Breast Cancer: Tumourigenesis and Drug Resistance
When breast cancer is detected at an early localized stage, surgery is often successful in achieving long term survival. However, when breast cancer becomes invasive and progresses to metastatic disease, surgery followed by adjuvant therapies is required, and many patients fail to respond or …
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Modeling Epithelial Ovarian Cancer In The Mouse
For over five decades epithelial ovarian cancer (EOC) is identified as the leading cause of death from gynecological malignancies in the USA. Unfortunately, due to latent progression of EOC and lack of accurate animal models studies of this disease's pathogenesis have been challenging. Not …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
Cancer cells preferentially utilize glycolysis to generate energy even in the presence of sufficient oxygen for oxidative phosphorylation. This shift in energy metabolism, termed the Warburg effect, is responsible for cancer cells’ high metabolic rate. Therapies that inhibit cancer cell energy …