Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"cancer model"”.
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Biomimetic and vascularized 3-d liver cancer model
… trials. This should be predicted by in vitro models, and yet 2D in vitro models of liver cancer co-administered with these two types of drugs show increased cell viability, contradicting clinical trials. In vitro models should mimic clinical trials in order to accurately predict drug outcomes. …
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The Development of the Prognostic Breast Cancer Model PREDICT
… making for patients with early invasive breast cancer. Since its development in 2010, the model has shown a variety of prognostic outcomes among numerous studies. Due to improvements in breast cancer survival and advancements in cancer treatments, the model might be outdated and could lead to …
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Providing a Malleable, Genetically Defined Cancer Model: A Porcine Solution
… of this project is to develop a swine animal model of cancer. There is a pressing need to develop new models to study cancer in an animal that is genetically, anatomically, and physiologically more analogous to humans and that metabolizes drugs and undergoes tumorigenesis similar to humans. …
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Effects of Combined Bevacizumab and Paclitaxel On Tumor Interstitial Fluid Pressure In A Preclinical Breast Cancer Model
… Fluid Pressure in a Preclinical Breast Cancer Model by Ricardo H. Alvarez Several mechanisms of cell resistance are often accountable for unsuccessful chemotherapy against cancer. Another reason, which has received increased attention, is the inefficient transport of anticancer drugs …
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A GNAQ/11-driven zebrafish cancer model identifies MITF and YAP as key determinants for uveal melanoma
Uveal melanoma (UM) is a cancer of eye melanocytes that has a particularly poor prognosis and a dearth of treatment options. In contrast to cutaneous melanoma (CM), which is driven by oncogenic mutation of BRAF or NRAS, UM is driven by oncogenic mutations in GNAQ or GNA11 (>80% of patients). We …
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Role of shNDPK and E-Cadherin in Growth and Metastasis of an Inflammatory Breast Cancer Model (MARY-X)
MARY-X, an inflammatory breast cancer (IBC) murine xenograft, exhibits the formation of florid lymphovascular emboli in vivo and spheroid formation in vitro. IBC is highly invasive and metastatic and our model presents the same in mice as it does in human. Therefore, studying the molecular …
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Multi-Omics Analysis of 3D SKOV3 Ovarian Cancer Model Cell line Cultured on Novel Silicon-Titanium Diboride Micropatterned Substrate
Ovarian cancer (OC) remains one of the deadliest cancers affecting women globally, with an estimated number of three hundred thousand new cases and about two hundred thousand deaths annually. The 5-year survival rate of ovarian cancer is approximately 30% or less when diagnosed during the advanced …
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EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
Pancreatic cancer (PC) is a lethal disease and have a poor prognosis as well as resistance to chemotherapy and radiation therapy. PC have two subtypes, Pancreatic ductal adenocarcinoma (PDAC) and Pancreatic neuroendocrine tumors (NETs). Between the two subtypes PDAC represent majority of the …
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Supplementation of licorice root and epimedium in a control or high fat diet and their effects on a preclinical metastatic breast cancer model
… may play a role in the progression of breast cancer. The majority of botanicals lack established data on safety and efficacy. They also present the likelihood for interactions to occur, such as with the high fat diet that is consumed in many Western countries. Two such botanicals, licorice …
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Proteomic Profiling of Pro and Active Matrix Metalloproteinases using Tandem Mass Spectrometry. Optimization of Affinity Chromatography and nHPLC-MALDI-MS/MS for Proteomic discrimination of Matrix Metalloproteinases in pre-clinical Cancer Model.
… in biological samples. Moreover, MMP-based anti-cancer drug development has also been challenged because, currently, there is no robust methodology to distinguish the inactive pro-enzymes, active enzymes or those complexed with endogenous inhibitors in biological specimens. The objective of this …
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The Analysis of the MCF7 Cancer Model System and the Effects of 5-AZA-2'-Deoxycytidine Treatment on the Chromantin State Using a Novel Microarray-Based Technology for High Resolution Global Chromatin State Measurement
… and advanced data analysis, and was applied to a cancer model system. Chromatin is first separated by its condensation state using chromatin fractionation. By probing with a comparative genomic hybridization-style microarray, the chromatin condensation state of thousands of individual loci in an …
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Investigating a novel small molecule inhibitor of nuclear import as an anti-cancer approach
The identification of novel cancer-associated biomarkers against which drugs can be developed is anticipated to be beneficial in multiple ways; including their use as monotherapies and in combination with current chemotherapeutic agents for improved anti-cancer treatment outcome. Recently, research …
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Investigating the role of PKC-β in tumour activated stromal cells
… the role of PKC-β in stromal cells of other cancers remains largely uncharacterised. Here I demonstrate novel mechanistic insights into BMSC- mediated drug resistance in CLL. Stromal PKC-β activation regulates levels of active transforming growth factor beta 1 (TGF-β1) and gene expression of …
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Computation of population and physiological risk parameters from cancer data
A biological hypothesis known as the "two-stage cancer model" conceptualizes carcinogenesis in mathematical terms. Prof. W. Thilly (MIT) and Prof. S. Morgenthaler (ETH,) and their students, especially Dr. Pablo Herrero-Jimenez have organized age- and birth cohort-specific cancer mortality data from …
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The Substituted Pyrrole JB-03-14 Induces Autophagic Cell Death and Growth Arrest in Breast Tumor Cells
The use of chemotherapy in the treatment of cancer has stimulated the demand for better chemotherapeutic agents that are more potent at destroying tumor cell populations and more selective for the specific tumor versus normal host tissues. This project is directed at discovering new anti-tumor …
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Dissecting The Molecular Mechanism of Early Tumor Dissemination In Non-Small Cell Lung Cancer
<p>Lung cancer is the most common cause of cancer related death in the United States and worldwide. It has been shown that 30%-55% of patients with early stages of non-small cell lung cancer (NSCLC) developed and died of recurrence after curative resection, suggesting that tumor cell dissemination …
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Investigating the role of PTPRK in homeostasis and disease
… during essential processes, such as junctional remodelling. Plasma membrane-localised receptor PTPs (RPTP) are well positioned to sense external environmental cues, such as cell-cell contact, and transmit signals via their intracellular domains. Using unbiased approaches we find RPTP, PTPRK binds …
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Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer
In recent years, the cancer stem cell hypothesis has emerged as a compelling but controversial model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are hierarchical and only a rare subpopulation of …
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TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
… on in transformed hepatocytes in two liver cancer models induced by DEN and overexpression of Neu respectively. Moreover, germline whole-body knockout of TSPAN8 significantly suppresses the tumor development in the DEN-induced liver cancer model. Using CRISPR/Cas9 knockout approach, we …
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