Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cancer marker"”.
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Human GINS, a conserved DNA replication factor and candidate cancer marker
… value of MCM proteins as specific and sensitive markers for cancer screening, I investigated whether GINS subunits also have potential diagnostic value. Sld5 and Psf3 expression is restricted to the proliferative compartment in normal tissue, but is found in the majority of cells in a wide range …
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Towards Early State Disease Detection in Microdevices: Fabrication and Testing of Micro Total Analysis Systems for Bioanalytical Applications
… potential application in biomolecular analysis. Cancer marker analysis is important for medical research and applications. I report a method that can covalently attach appropriately oriented antibodies of interest on monolith surfaces. To reduce nonspecific adsorption, protein solutions were used …
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Development of tissue printed nitrocellulose cards/arrays for real time PCR amplification and detection
… Laboratory is currently developing a novel cancer marker imaging system for detection of cancerous tissue, which will be useful for discerning tumor margins. This research will advance the recent application of tissue print technology in bio-medicine by combining it with imaging and real …
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Antibody-based biosensor assays for the detection of zilpaterol and markers for prostate cancer
… against prostate-specific antigen (PSA), a cancer marker. Polyclonal antibodies were used in the development of immunoassays in a competitive ELISA format and on the Biacore (a surface plasmon resonance-based optical biosensor capable of monitoring biomolecular interactions in 'real-time'). …
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Assessment and Diagnosis of Human Colorectal and Ovarian Cancer using Optical Imaging and Computer-aided Diagnosis
… associated with the development of colorectal cancer. We have observed a specific mucosa structure indicating normal human colorectal tissue, and have developed a real-time pattern recognition neural network to localize this specific structure in OCT images, enabling classification of the …
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Tissue Transglutaminase And Its Role In Human Cancer Progression
… expression is up-regulated in several human cancers. Here I show that tTG is a key participant in a novel EGFR/Src-signaling pathway and a potential target for inhibiting EGFR-promoted tumor progression. Specifically, EGF up-regulates tTG expression in human breast cancer cells, and …
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INVESTIGATING THE ROLE OF EXTRACELLULAR VESICLES AND GLYCOSYLATION IN CANCER METASTASIS
Breast and colorectal cancers present significant challenges for the UK healthcare system, placing a substantial burden on the National Health Service (NHS). Early detection is crucial for improving survival rates and reducing healthcare strain, especially as metastasis, the primary cause of …
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Investigating the role of extracellular vesicles and glycosylation in cancer metastasis
Breast and colorectal cancers present significant challenges for the UK healthcare system, placing a substantial burden on the National Health Service (NHS). Early detection is crucial for improving survival rates and reducing healthcare strain, especially as metastasis, the primary cause of …
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Development of coupled enzyme assay and in vitro synthetic biology approach for glycosylation pathway characterization
… of MUC1 that is associated with certain cancers. Central to this is an accurate MUC1 peptide monomer and associated glycosyltransferases (GTs) able to be deployed in specific construction. However, deconstructing the machinery of the GTsubstrate interactome is challenging because of the …
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Improving ultrasound display by retrieving high-frequency sonographic information
… in improved visibility of an important breast cancer marker, microcalcifications. Our new results in analyzing intensity statistics provided a linear system framework to pursue our goal. Our analysis shows that intensity signals only contain low spatial-frequency components of the object, while …
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Biosynthesis of Poly-3-Hydroxybutyrate and its Application in Controlled Drug Delivery
… drug delivery systems, with potential anticancer therapy applications. Three derivatives of a commonly used photosensitiser, namely porphyrin, were encapsulated within P(3HB) microspheres. The reduction in cell viability of these with respect to drug loading was quantified. Encapsulation …