Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"cancer immunotherapy"”.
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Integrin-targeted cancer immunotherapy
… (RGD) motif, are heavily overexpressed in many cancers relative to healthy tissue, making them attractive targets for therapeutic intervention. However, prior attempts to antagonize these integrins as a cancer therapy have all failed in the clinic. In this thesis, we instead exploit integrins as …
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… for protection and treatment with regards to cancer vaccines and viral infections, including HIV. The potency of resting CTLs in LFS immunized mice was investigated with a viral LCMV challenge months after a single immunization. Following the viral challenge, LFS-immunized mice had a much …
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Cancer immunotherapy with Mucin-1 and cytokines
Cancer immunotherapy involves the manipulation of the immune response to combat tumour cells. The studies contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, …
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Radiographic Challenges and Considerations with Cancer Immunotherapy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Engineering dendritic cells for enhanced cancer immunotherapy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Engineering persistent interleukin-2 for cancer immunotherapy
… tumor cells is a promising strategy for treating cancer. In contrast to standard therapeutic approaches such as surgery, radiation, and chemotherapy, immunotherapy offers the possibility of systemic yet tumor-specific cell killing as well as long-lasting cancer protection. A significant mode of …
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Yeast-based vaccine approaches to cancer immunotherapy
… cells and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful induction of cellular immunity. Using a yeast vaccine model, we investigated the phagosome-to-cytosol pathway of …
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Collagen Anchoring Agonist Antibodies for Cancer Immunotherapy
While traditional cancer interventions such as surgery, radiation, and chemotherapy are aimed at killing or removing the tumor cells themselves, immunotherapies instead seek to establish long-lasting, robust antitumor immune responses. One approach that has shown promising results in preclinical …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
… in chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Myeloid cells are actively recruited to the tumor microenvironment (TME), where tumor associated macrophages (TAMs) are often the most abundant …
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Computational dissection and prediction of cancer immunotherapy response
… the standard of care and outcomes for many cancer types; however. more than 60% of patients still do not experience a durable clinical response from these treatments. To address this problem, the development of novel biomarkers and more effective combinatorial therapies are needed. In this …
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Layer-by-layer coated microneedles for cancer immunotherapy
… the past few decades, research in therapeutic cancer vaccines has achieved remarkable advances in both pre-clinical and clinical studies. However, strategies to boost antigen presentation and T cell priming in order to increase the fraction of patients responding to immunotherapy remains an …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
Immunotherapy has transformed the field of oncology. However, clinical challenges of toxicity and low response rate offer opportunities to develop novel, rational strategies to integrate into current clinical oncology treatment. To address these challenges, we designed a novel local mesenchymal …
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Immune modulating functions by soypeptide lunasin in cancer immunotherapy
… is currently the mainstay of treatment for most cancer patients. Despite its efficacy in eliminating cancer cells, a high percentage of chemotherapy patients eventually relapse or suffer progression of the disease. Immunosurveillance is capable of recognizing and eliminating continuously arising …
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Single-cell Functional Profiling of Lymphocytes for Cancer Immunotherapy
Immunotherapy by harnessing patients’ the immune system has changed the landscape of cancer therapeutics and shown promising and remarkable clinical responses. However, not all the patients would be beneficial from the treatment. Lymphocytes are a significant target in anti-tumor immunotherapy, and …
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Locally Administered Particle-Anchored Cytokines Safely Enhance Cancer Immunotherapy
Cancer immunotherapy has long been proposed as a powerful approach to curing tumors, based on the natural function of the immune system in protecting its host with specificity, thus holding the potential for developing long-term memory that prevents tumor recurrence. However, the immunosuppressive …
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Microencapsulation of Bacillus calmette-guerin for use in cancer immunotherapy.
… of Bacillus calmette-guerin for use in cancer immunotherapy.
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Transcription factor modulation in T-cells to improve cancer immunotherapy
… (AhR), during CAR-T production could enhance immunotherapy efficacy. NOTCH signaling controls both stem cell self-renewal and cellular differentiation across diverse tissues. NOTCH1 agonism restricted the differentiation of CAR-T derived from naïve CD4+ T-cells, and upregulated expression of …
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A materials-based approach for localized delivery of cancer immunotherapy
Cancer immunotherapy provides a promising new alternative to traditional cancer treatment modalities such as chemotherapy and radiation. However, even the most effective therapies only show benefit in a subset of patients when used alone and so, combination therapy may be critical to maximizing …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
In recent years, immunotherapy has achieved unprecedented success in the clinic, especially in melanoma, kidney, bladder, head and neck, renal, and lung cancers. However, similar outcomes have yet to be achieved in metastatic breast cancer (mBC). This is likely in part due to the presence of an …
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