Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"cancer immunology"”.
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Machine Learning Methods for Cancer Immunology
… immune destruction is a fundamental hallmark of cancer, and elucidating the contextual basis of tumour-infiltrating leukocytes is pivotal for improving immunotherapy initiatives. However, progress in this domain is hindered by an incomplete characterisation of the regulatory mechanisms involved …
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Mathematical Modelling of the Immune Response to Cancer
… transformed cells becoming malig- nant tumours (cancers). More recently, the subject of cancer immunology has been concerned with examining the local effects the immune system has on a pre-angiogenic tumour site. A recent immunological review article - “The Three Es of Cancer Immunoediting” - …
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Proteomic studies on patient responses to chemotherapy, radiotherapy and immunotherapy in cancers
… evidence that the aberrant expression of cancer-testis (CT) antigens - a family of ca. 150 proteins that are both autoimmunogenic and mainly restricted to tumours in various types of human cancers - makes them attractive immunotherapy targets, as well as possible cancer diagnostic markers. …
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Functional Genomic Studies of Cancer Immune Evasion Using In Vitro and In Vivo CRISPR/Cas9 Genetic Screens
Recent advances in cancer immunology have shed light on the mechanisms of cancer immune evasion. An accumulation of data in recent years has identified several immune checkpoints, whose expression by cancer cells allows them to evade anti-cancer immune responses. The great potential of these …
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Investigating functions of tumor-infiltrating natural killer cells in genetically-engineered mouse models of non-small cell lung cancer
… After many years of skepticism, the field of cancer immunology has recently undergone a major revolution. The success of modern immunotherapeutics has transformed the arenas of oncology and drug development. Large efforts are now focused on understanding the factors that dictate patient …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
Regulatory T cells are one of the integral components of the adaptive immune system that contribute to the regulation of anti-tumor T cell responses. However, studies have suggested that alterations in T cell signaling networks can result in T cells that are resistant to the suppressive effects of …
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Effect of Systemic Versus Localized Bacillus Calmette-Guérin Immunotherapy on Bladder Cancer Progression: Novel Role for Trained Immunity
… care for high-risk non-muscle invasive bladder cancer (NMIBC) involves intravesical immunotherapy with Bacillus Calmette Guérin (BCG). Unfortunately, most patients do not respond fully to this therapy, and our understanding of the immunotherapeutic effect of BCG is incomplete. The tumor immune …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
… of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of individual patients. Tumors are complex and organized tissues that include multiple cell types, which together …
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Modelling pancreatic cancer in vivo with patient derived organoids & humanised mouse models for the investigation of immunotherapeutic treatment response
… (PDAC) is the most prevalent form of pancreatic cancer, with a median survival time of <11 months. While incidences of PDAC continues to rise, treatment options remain limited and largely ineffective. The complex genomic, microenvironmental and immunophenotypic heterogeneity of PDAC tumours …
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Characterization, representation, and prediction of immune cell states using single-cell sequencing and machine learning
… by Turep, a deep-learning framework for cross-cancer tumor-reactive T cell identification. Turep identifies tumor-reactive clones in an antigen-agnostic manner and reveals active tumor-recognition regions within the tissue architecture when extended to spatial transcriptomics.</p> …
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Characterisation of the Tumour Microenvironment in Ovarian Cancer
The tumour microenvironment comprises the non-cancerous cells present in the tumour mass (fibroblasts, endothelial, and immune cells), as well as signalling molecules and extracellular matrix. Tumour growth, invasion, metastasis, and response to therapy are influenced by the tumour …
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Integrative Cancer Immunogenomic Analysis of Serial Melanoma Biopsies Reveals Correlates of Response and Resistance to Sequential Ctla-4 and Pd-1 Blockade Treatment
<p>Melanoma is the most malignant form of skin cancer. The five-year survival rate for metastatic melanoma is 19.9%. Although targeted therapy of BRAF and MEK inhibitors were developed for melanoma, resistance to therapy is inevitable. Immune checkpoint blockade, which reverses the suppression of …
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Development of An In Silico Kir Genotyping Algorithm and Its Application to Population and Cancer Immunogenetic Analyses
… to an analysis of 5489 germline exomes from cancer patients spanning 22 disease groups. After stratifying the samples by race and ethnicity, the results show no significant correlations between KIR gene content and cancer but did identify a transmembrane domain polymorphism in the KIR3DL3 …
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Mechanisms of CD4+ Regulatory T Cell Heterogeneity in Health and Disease
Regulatory T (Treg) cells are central to the maintenance of immune homeostasis and their dysfunction underlies the pathology of numerous diseases. Treg cell populations are phenotypically heterogeneous, comprising functionally quiescent resting Treg (rTreg) cells, which upon antigen stimulation, …
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Antioxidant PRDX1 limits CD8+ T cell effector function in the tumour microenvironment
… However, under this selection pressure, cancer cells progressively evolve mechanisms to undermine and subvert host immunity. Immunotherapy aimed at restoring or enhancing endogenous CD8+ T cell function has had profound clinical success and exemplifies the anti-tumour potential of T cell …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
Cancer is one of the major causes for the mortality in the whole world and among the cancers, glioblastoma is the most common and aggressive form of malignant brain tumours, especially in the adults. The complex tumour microenvironment of glioblastoma contributes to immune suppression and …
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Computational profiling of the tumour immune microenvironment
A tumour comprises not only cancer cells but other populations, including immune and stroma, collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and …
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
… immune homeostasis and in eliminating cancerous cells. In recent years it has emerged that cellular metabolism is a central regulator of T cell fate and function. T cell metabolic profiles rapidly fluctuate following T cell activation and can be highly influenced by microenvironmental …
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Protective or Problematic? Investigating the role of the innate immune receptor NLRX1 as a tumor suppressor or promoter in breast and pancreatic cancer
… signaling which both have implications in cancer. NLRX1 can regulate additional cancer-associated pathways, such as MAPK and AKT, and cancer-associated functions like metabolism and reactive oxygen species (ROS) production. Interestingly, depending on the type and subtype of cancer, NLRX1 …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… and an inflammatory subtype of colorectal cancer being Colitis-Associated Colorectal Cancer (large intestine). We study this pathway via the use of murine models bearing genetic deletions, cellular models, and the generation of miniature organs (i.e. "organoids") in petri dishes. Further, …
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