Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cancer immunoediting"”.
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Tumor Antigens Revealed by Exome Seqeuncing Drive Editing of Tumor Immunogenicity
<p>Accumulated data from animal models and human cancer patients strongly support the concept that immunity cannot only function as an extrinsic tumor suppressor, but also shape tumor immunogenicity. These observations led to the development of the cancer immunoediting hypothesis that stresses the …
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Mathematical Modelling of the Immune Response to Cancer
… transformed cells becoming malig- nant tumours (cancers). More recently, the subject of cancer immunology has been concerned with examining the local effects the immune system has on a pre-angiogenic tumour site. A recent immunological review article - “The Three Es of Cancer Immunoediting” - …
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Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
There is evidence from cancer patients and animal models that the immune system is able to recognise cancer cells. It is unclear whether tumours escape this immune surveillance by selection of non-immunogenic variants in a Darwinian process termed cancer immunoediting, or by the recruitment of …
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Development of an IL12 Prodrug to Treat Solid Tumors with Minimal Toxicity
… Cell-mediated immunity plays a critical role in cancer immunoediting, allowing CTLs to recognize and kill aberrant cells. Because of this, IL12 has been tested in many different preclinical and clinical studies for its potential use as an anti-tumor therapeutic agent. However, IL12 also causes …