Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"cancer immune evasion"”.
-
Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
<p>Glycosylation of immune receptors and ligands, such as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of …
-
Functional Genomic Studies of Cancer Immune Evasion Using In Vitro and In Vivo CRISPR/Cas9 Genetic Screens
Recent advances in cancer immunology have shed light on the mechanisms of cancer immune evasion. An accumulation of data in recent years has identified several immune checkpoints, whose expression by cancer cells allows them to evade anti-cancer immune responses. The great potential of these …
-
Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
… for normal cell function, it is no surprise that cancer cells leverage lipid metabolic pathways to fuel uncontrolled growth and proliferation and evade cell death. Indeed, enhanced lipid availability has been implicated in tumor initiation, growth,and metastasis, and metabolic genes involved in …
-
Identification of the role of transcription factor ETV7 in breast cancer aggressiveness
… repressor, known to be up-regulated in breast cancer (BC). Firstly, we demonstrated a new role of ETV7 in promoting breast cancer stem-like cell (BCSC) plasticity and resistance to chemotherapy in BC cells. We observed that ETV7 repressed a large panel of interferon response genes and increased …
-
Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
Despite considerable progress in conventional cancer therapies, major challenges persist in the treatment of patients with advanced stage malignancies. Cancer immunotherapy (harnessing the immune system against tumors) has demonstrated limited success to date, partially due to the immunosuppressive …