Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"cancer etiology"”.
-
INFLAMMATION INDUCED CYTOSINE DEAMINATION DAMAGE IN CANCER ETIOLOGY
Cancer is a major health challenge worldwide, and inflammation is thought to be an important factor in cancer etiology. The mutational landscape of human cancer is dominated by cytosine to thymine transition mutations, and the primary mechanism for these mutations is the deamination of cytosine and …
-
Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells
… ERalpha-positive and HER2-negative MCF-7 breast cancer cell lines. LRIG1 regulation by estradiol may be important for breast cancer etiology and phenotypic properties by influencing signaling pathways such as the AKT and MAPK pathways, which help to determine the breast tumor subtype as well as …
-
Chronic cadmium exposure alters ERα dependency and drug sensitivity of breast cancer cells
<p>The global prevalence of breast cancer in women illustrates the importance of identifying factors that contribute to disease onset and progression. Endogenous and environmental agents that interact with estrogen receptor alpha (ERα) have been shown to play a role in breast cancer etiology. …
-
Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
… deregulation of YAP has been associated with cancer etiology, no compounds are known to specifically modulate its functions. Here we identified an inhibitor of YAP functionality, called GF 10923X, and we proposed it as a potential lead molecule to be used against disease where YAP is found …
-
THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
… One of the more compelling hypotheses in breast cancer research is that transformation of a particular cell within the hierarchy will initiate a tumour with a specific molecular profile and clinical outcome. If this is true, valuable insight into tumourigenesis can be gained by investigating …
-
Inflammatory processes and risk of cancer: epidemiological research.
Chronic inflammation has been implicated in cancer etiology but it is unclear whether inflammation causes cancer or results from tumor growth. To address these questions, we examined three hypotheses about the role of inflammation in incident cancers in large prospective cohorts. In the first …
-
Origin, evolution, and global spread of a transmissible cancer clone
Clonally transmissible cancers are malignant cellular clones that spread between unrelated individuals by the physical transfer of living cancer cells. These clones can ‘metastasise’ through populations, having adapted to transmit across external environments and evade the host immune response. …
-
Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme
… cytoplasm. Many Sirtuins targets are involved in cancer and in many types of cancers, SIRT1 is found to be overexpressed. Recent observations support SIRT1 being both an oncogene and a tumour suppressor, depending on the cancer etiology and type of tissue. To answer the question “How can SIRT1 …
-
Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells
… expression of over a thousand genes in breast cancer cells. As a master regulator of transcription, ER can impact the transcription and subsequent expression of many proteins that ultimately determine the growth and invasiveness of a tumor. As a transcriptional regulator, activation of ER with …
-
Prevalence of vitamin D insufficiency among breast cancer survivors
… is a prevalent problem for female breast cancer survivors (BCS) who have completed treatment for breast cancer. Ninetynine breast cancer survivors and a control population of fifty-five women with no history of breast cancer participated in this study. Serum 25-hydroxy vitamin D …
-
The Role of METTL21A in Kras-driven Cancers
… the human proteome, and many were implicated in cancer etiology. However, the catalytic activity and substrate specificity for many of these enzymes remain unknown. Our work aimed to explore the role of Methyltransferase like 21A (METTL21A), amember of the little-studied seven β- strand family of …
-
PARSES: A Pipeline for Analysis of RNA-Sequencing Exogenous Sequences
RNA-Sequencing (RNA-Seq) has become one of the most widely used techniques to interrogate the transcriptome of an organism since the advent of next generation sequencing technologies [1]. A plethora of tools have been developed to analyze and visualize the transcriptome data from RNA-Seq …