Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 118 for “"cancer drugs"”.
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Quantitative pharmacoproteomics investigation of anti-cancer drugs in mouse. Development and optimisation of proteomics workflows for evaluating the effect of anti-cancer drugs on mouse liver
Minimizing anti-cancer drug toxicity is a major challenge for the pharmaceutical industry. Toxicity is most frequently due to either the direct interaction of the drug on previously unidentified targets or its conversion to metabolites by drug metabolizing enzymes (e.g. CYP450 enzymes) that cause …
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Co-encapsulation of anti-breast cancer drugs in nanoparticles reduce antagonism
… dictated therapy outcome and the probability of cancer remission. Differential metabolism of docetaxel (DCL) and tamoxifen (TAM), which resulted in drug antagonistic effects were shown to suppress treatment efficacy in subpopulation of cancer cells. However the potential of nanoparticles, which …
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Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs.
… activity towards the inhibition of prostate cancer cell growth using staurosporine a a positive control. All three compounds have shown significant inhibition of prostate cancer cell growth. Compound <b>9</b> is yet to be evaluated.</p>
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Synthesis of Ester Derivatives of Resveratrol as Potential Anti-Cancer Drugs
… wine. Resveratrol has been found to exhibit anti-cancer, anti-inflammatory, anti-aging, and anti-oxidant properties. Research indicates that diets enriched with resveratrol containing substances result in less incidence of cancer. Unfortunately, the low bioavailability and solubility has been a …
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An Investigation of the Coordination Chemistry of Certain Anti-Cancer Drugs
Made available in DSpace on 2014-12-05T19:38:00Z (GMT). No. of bitstreams: 1 6206127.pdf: 3382935 bytes, checksum: 7f10ef0b0b50988c1ea77a2044728f9c (MD5) Previous issue date: 1962
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Computer-aided drug design and the biological evaluation of anti-cancer drugs
… transcription factor that has a pivotal role in cancer survival and Pentamidine, an anti-parasitic drug that has recently been demonstrated to possess tumour-killing activity. A hierarchical methodology consisting of a similarity search followed by structure-based virtual screening of the ZINC …
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Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… pre-clinical development as hypoxia-activated prodrugs and as so-called payloads for antibody-drug conjugates for the treatment of cancer. Although the mechanism of action (MOA) of duocarmycins has been elucidated as DNA minor groove alkylation, not much is known about the factors involved in the …
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An Economic and Regulatory Analysis of Breast Cancer Drugs Approved by the US Food and Drug Administration
<p><strong>Introduction</strong></p> <p>Breast cancer is the most common cancer among women and the leading cause of cancer death among women worldwide. The pharmacological options for breast cancer include chemotherapy, hormone therapy, targeted therapy, and immunotherapy, which are used for the …
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The relationship between p53 mutations and differential sensitivity to anti-cancer drugs in oesophageal cancer cell lines
In South Africa, cancer of the oesophagus is the leading cause of death in black males and overall the fourth most common cancer. Development of resistance to chemotherapeutic agents hinders the successful treatment of several cancers. In order to characterise drug resistance in several South …
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Decoupling market incumbency from organizational experience : a study of biotechnology's impact on the market for anti-cancer drugs
In studies of creative destruction, scholars agree that, within research-intensive industries, the demise of incumbents is significantly determined by their lower productivity in researching the radically new technology (Henderson, 1993). Such differences in the research competence of incumbent vs. …
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Applying System-Theoretic Accident Model Process view to patient safety for treatment with oral chemotherapy and anti-cancer drugs
… healthcare workers particular to the Dana-Farber Cancer Institute. The suggested control structure will ultimately lay the groundwork for future work on a detailed Systems-Theoretic Process Analysis (STPA) and generate specific recommendations to help address the identified risks and hazards in …
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Study Of The Photodegradation And Photostability Of Anti-Cancer Drugs In Different Media Towards The Development Of Both New Actinometers And Liquid Formulations
… and liquid formulation development. Three anti-cancer drugs will be employed as models; Dacarbazine (DBZ) has well established photostability issues, Axitinib (AXI) and Sunitinib (SUT) are two new drugs only commercially available in solid dosage forms. In ethanol, the photokinetics of these …
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Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs: Pharmacological Evaluation in Phenotypically Diverse Breast Cancer Models and Pharmacokinetic Assessment in Liver Microsome and Female Mouse Models
… risk of both invasive and non-invasive breast cancer (BC) as well as tumor recurrence in several clinical trials. However, chronic use of tamoxifen can increase uterine cancer risk and induce tamoxifen resistance. In past studies, melatonin alone reversed tamoxifen resistance induced by light …
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Can Medicare afford to pay for oral chemotherapy drugs? : an evaluation of the problem and introduction of a model to estimate cost
Recently, effective oral cancer drugs are gaining prominence. This trend toward oral chemotherapy has important economic implications: the Medicare system of the United States pays for all intravenous (IV) chemotherapy, but it covers only those oral drugs that have an equivalent IV formulation …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant …
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STUDYING THE INTERACTION OF CANCER AND THROMBOSIS THERAPEUTICS WITH PROTEIN AND DNA
… different classes of therapeutics. Many cancer drugs bind to DNA and inhibit replication. We have AFM and simulations, based on the worm-like chain model (WLC), to study DNA conformational changes due to its interaction with two cancer drugs, cisplatin and Pt-Acramtu. We found that …
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Lithium-Carbonate as a Protectant Against Chemotherapy-Induced Myelosuppression
Lithium carbonate has been used as an adjunct to cancer chemotherapy to lessen the dose-limiting myelosuppressive effects of several anti-cancer drugs. Its mechanism is unknown, but several possible sites of action have been considered. Lithium causes a neutrophilia and may protect the bone marrow …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… has been made in reducing mortality in some cancers, mortality rates remain high in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were evaluated. …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… has been made in reducing mortality in some cancers, mortality rates remain high in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were evaluated. …
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Physician behavior and technology diffusion in health care
… with Leila Agha) explores the diffusion of new cancer drugs by testing the influence of physician investigators who lead clinical trials. The basic idea is to exploit variation across drugs in the location of clinical trials to test whether geographic proximity to a principal investigator …
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