Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"cancer driver mutations"”.
-
Tissue adaptations to colitis influence neoplastic risk through clonal interaction
Despite a significant fraction of worldwide cancer cases being linked to chronic inflammation, full understanding of the neoplastic process in this context is lacking. The profound tissue remodelling described in chronic inflammatory diseases suggests that alteration of reciprocal signalling …
-
Prevalence and fate of pro-oncogenic clones in the human colon
… tissues are thought to exist as a patchwork of mutations. The detection of cancer-driver mutations in the normal human colonic epithelium had been so far limited. Using immunohistochemistry and sequencing methods, and by screening a large number of patients and crypts, pro-oncogenic clones were …
-
Integrated Machine Learning and Bioinformatics Approaches for Prediction of Cancer-Driving Gene Mutations
<p>Cancer arises from the accumulation of somatic mutations and genetic alterations in cell division checkpoints and apoptosis, this often leads to abnormal tumor proliferation. Proper classification of cancer-linked driver mutations will considerably help our understanding of the molecular …
-
Inferring context-specific essentiality networks using large-scale CRISPR-KO screens
… offer insights into vulnerabilities of different cancer types and provide promising targets for personalized cancer therapies. However, the challenge is to systematically identify and define those context-essential genes and to understand how cellular phenotype and interaction networks are altered …
-
Transcription Factor-Centric Approaches to Identify Regulatory Driver Mutations in Cancer
<p>Most previous efforts to identify cancer driver mutations have focused on protein-coding genes. In recent years, the decreasing costs of DNA sequencing have enabled whole-genome sequencing (WGS) studies of thousands of tumor samples, making it possible to systematically survey non-coding regions …
-
Identifying unique cell states in early liver oncogenesis with transcription coupled repair
Many cancers, such as the main form of primary liver cancer hepatocellular carcinoma (HCC), typically arise in tissues with a high number of genetic mutations which drive cell growth aberrantly. These mutations appear to precede tumour initiation, as DNA sequencing has shown that cancer driver …
-
Investigating the Role of Oncogenic KRAS G12 Mutations in Cell Signalling
Cancer is a multistep process reflecting genetic alterations that drive progressive transformation of normal cells into highly proliferative malignant cells. Deregulation of cellular signalling is one of the key traits in cancer, allowing cells to breach anticancer defence mechanisms. The most …
-
Pan-cancer study of transcriptional responses to oncogenic somatic mutations
Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene expression in the nucleus, driving the cell toward a cancerous phenotype. …
-
Multicomponent Complexes, Structural Proteomes, Drug Discovery For Cancer Gene Census And SARS CoV-2
… actual biological assembly. There are two main drivers for computational structural modelling: first, to reduce the colossal sequence- structure gap, and second, to understand the impact of mutations in human cancer and new variants from viruses on the protein structure. The Catalogue of Somatic …