Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"cancer driver gene"”.
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… for its role in post-transcriptional control of gene expression and is reported as a newly identified cancer driver gene. Replication stress (RS) threatens DNA replication fidelity and stability of the genome. Recently, a small number of AU-RBPs have emerged as key figures in the maintenance of …
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Investigating the Involvement of RNA-Binding Protein ZFP36L1 in Breast Cancer Progression
… mRNA decaying. ZFP36L1 has emerged as a breast cancer driver gene, exhibiting tumour-suppressing properties. Notably, ZFP36L1 has been reported to be significantly mutated and downregulated in various tumour types. In our comprehensive study, we identified the novel role of the ZFP36L1 gene in …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… Questi geni Over-UpT sono arricchiti di "Fitness Genes", molti dei quali coinvolti nell’inizio della traduzione e nella poliadenilazione dell'mRNA. In questa tesi, sono stati analizzati i profili genomici e trascrittomici dei geni correlati ai pathway Fitness-OverT, tra cui eIF2, eIF3, CSTF e …